Implantable lead with dissolvable coating for improved fixation and extraction
First Claim
1. A device including:
- a device body at least partially covered by a peripheral surface; and
an at least partially dissolvable coating at least partially on a portion of the peripheral surface of the device body, the coating providing at least one of a rough surface and a porous surface after being exposed to an aqueous substance.
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Accused Products
Abstract
A cardiac rhythm management system provides an endocardial cardiac rhythm management lead with an at least partially dissolvable coating at least partially on insulating portions of the lead body at or near its distal end. Upon dissolution, the coating promotes tissue ingrowth to secure the lead in place within fragile vascular structures or elsewhere. Dissolution of one such coating releases a therapeutic agent, such as a steroid that modifies the fibrotic scar tissue content of tissue ingrowth, such that the resulting bond between the tissue and the lead is weak, so that the lead can be easily extracted if desired. One such lead includes an insulating elongate body carrying at least. The lead also includes an at least partially dissolvable coating on an insulating portion of the peripheral distal lead surface. The coating provides one or more of a rough surface, a porous surface, or a swollen surface after being exposed to an aqueous substance.
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Citations
59 Claims
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1. A device including:
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a device body at least partially covered by a peripheral surface; and
an at least partially dissolvable coating at least partially on a portion of the peripheral surface of the device body, the coating providing at least one of a rough surface and a porous surface after being exposed to an aqueous substance. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. A device including:
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a flexible elongate body having a proximal and a distal end and a peripheral surface; and
a partially dissolvable coating at least partially on a portion of the peripheral surface of the elongate body, the coating providing at least one of a rough surface, a porous surface, and a swollen surface after being exposed to an aqueous substance, the coating including a plurality of substantially soluble particles dispersed in a substantially insoluble silicone adhesive that is bonded to the elongate body, and in which the substantially soluble particles are selected from the group consisting of dexamethasone, dexamethasone acetate and dexamethasone sodium phosphate. - View Dependent Claims (17, 18, 19, 20, 21, 22)
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23. A device including:
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a flexible elongate body having a proximal and a distal end and a peripheral surface; and
an at least partially-dissolvable means for coating a portion of the peripheral surface at or near the distal end of the elongate body, providing at least one of a rough surface, a porous surface, and a swollen surface, after being exposed to an aqueous substance, for fixation of tissue thereto. - View Dependent Claims (24, 25, 26)
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27. A method including:
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implanting an implantable medical device;
exposing the an implantable medical device to an aqueous substance; and
partially dissolving a coating at least partially on a portion of the implantable medical device to provide at least one of a rough surface, a porous surface, and a swollen surface, thereby promoting tissue ingrowth. - View Dependent Claims (28, 29, 30, 31, 32, 33, 34)
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35. A method comprising:
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covering at least a portion of an implantable medical device with an insulating peripheral surface; and
coating at least a portion of the insulating peripheral surface with an at least partially dissolvable coating, the coating providing at least one of a rough surface, a porous surface, and a swollen surface after being exposed to an aqueous substance. - View Dependent Claims (36, 37, 38, 39, 40, 41, 42, 43, 44, 45)
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46. A device including:
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a device body at least partially covered by a peripheral surface; and
an at least partially dissolvable coating at least partially on a portion of the peripheral surface of the device body, the coating providing a rough surface after being exposed to an aqueous substance.
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47. A device including:
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a device body at least partially covered by a peripheral surface; and
an at least partially dissolvable coating at least partially on a portion of the peripheral surface of the device body, the coating providing a porous surface after being exposed to an aqueous substance.
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48. A device including:
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a flexible elongate body having a proximal and a distal end and a peripheral surface; and
a partially dissolvable coating at least partially on a portion of the peripheral surface of the elongate body, the coating providing a rough surface after being exposed to an aqueous substance, the coating including a plurality of substantially soluble particles dispersed in a substantially insoluble silicone adhesive that is bonded to the elongate body, and in which the substantially soluble particles are selected from the group consisting of dexamethasone, dexamethasone acetate and dexamethasone sodium phosphate.
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49. A device including:
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a flexible elongate body having a proximal and a distal end and a peripheral surface; and
a partially dissolvable coating at least partially on a portion of the peripheral surface of the elongate body, the coating providing a porous surface after being exposed to an aqueous substance, the coating including a plurality of substantially soluble particles dispersed in a substantially insoluble silicone adhesive that is bonded to the elongate body, and in which the substantially soluble particles are selected from the group consisting of dexamethasone, dexamethasone acetate and dexamethasone sodium phosphate.
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50. A device including:
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a flexible elongate body having a proximal and a distal end and a peripheral surface; and
a partially dissolvable coating at least partially on a portion of the peripheral surface of the elongate body, the coating providing a swollen surface after being exposed to an aqueous substance, the coating including a plurality of substantially soluble particles dispersed in a substantially insoluble silicone adhesive that is bonded to the elongate body, and in which the substantially soluble particles are selected from the group consisting of dexamethasone, dexamethasone acetate and dexamethasone sodium phosphate.
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51. A device including:
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a flexible elongate body having a proximal and a distal end and a peripheral surface; and
an at least partially-dissolvable means for coating a portion of the peripheral surface at or near the distal end of the elongate body, providing a rough surface after being exposed to an aqueous substance, for fixation of tissue thereto.
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52. A device including:
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a flexible elongate body having a proximal and a distal end and a peripheral surface; and
an at least partially-dissolvable means for coating a portion of the peripheral surface at or near the distal end of the elongate body, providing a porous surface after being exposed to an aqueous substance, for fixation of tissue thereto.
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53. A device including:
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a flexible elongate body having a proximal and a distal end and a peripheral surface; and
an at least partially-dissolvable means for coating a portion of the peripheral surface at or near the distal end of the elongate body, providing a swollen surface, after being exposed to an aqueous substance, for fixation of tissue thereto.
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54. A method including:
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implanting an implantable medical device;
exposing the an implantable medical device to an aqueous substance; and
partially dissolving a coating at least partially on a portion of the implantable medical device to provide a rough surface, thereby promoting tissue ingrowth.
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55. A method including:
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implanting an implantable medical device;
exposing the an implantable medical device to an aqueous substance; and
partially dissolving a coating at least partially on a portion of the implantable medical device to provide a porous surface, thereby promoting tissue ingrowth.
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56. A method including:
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implanting an implantable medical device;
exposing the an implantable medical device to an aqueous substance; and
partially dissolving a coating at least partially on a portion of the implantable medical device to provide a swollen surface, thereby promoting tissue ingrowth.
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57. A method comprising:
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covering at least a portion of an implantable medical device with an insulating peripheral surface; and
coating at least a portion of the insulating peripheral surface with an at least partially dissolvable coating, the coating providing a rough surface after being exposed to an aqueous substance.
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58. A method comprising:
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covering at least a portion of an implantable medical device with an insulating peripheral surface; and
coating at least a portion of the insulating peripheral surface with an at least partially dissolvable coating, the coating providing at least one of a porous surface after being exposed to an aqueous substance.
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59. A method comprising:
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covering at least a portion of an implantable medical device with an insulating peripheral surface; and
coating at least a portion of the insulating peripheral surface with an at least partially dissolvable coating, the coating providing a swollen surface after being exposed to an aqueous substance.
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Specification