Signal conditioning device for interfacing intravascular sensors having varying operational characteristics to a physiology monitor

• US 6,585,660 B2
• Filed: 05/18/2001
• Issued: 07/01/2003
• Est. Priority Date: 05/18/2001
• Status: Active Grant

• Current Assignee: Volcano Corporation (Koninklijke Philips N.V.)
• Original Assignee: Jomed Inc.
• Inventors: Eberle, Michael J., Dorando, Dale Gene, Hoseit, Paul Michael, Shell, Marc A., Gabbrielli, Janette D.
• Primary Examiner(s): Leung, Philip H.
• Application Number:
  US09/861,464
• Publication Number:
  US 20020173724A1
• Time in Patent Office: 774 Days
• Field of Search: 600/486, 600/488, 600/505, 600/487, 600/483, 600/485, 600/506, 128/920, 128/922, 737/08
• US Class Current: 600/486
• CPC Class Codes: A61B 2560/0252 using ambient temperature
• CPC Class Codes: A61B 2560/045 with a separable interface unit, e.g. for communication
• CPC Class Codes: A61B 2562/085 combined with means for recording calibration data
• CPC Class Codes: A61B 5/0215 by means inserted into the body catheters A61M25/00
• CPC Class Codes: A61B 5/743 Displaying an image simultaneously with additional graphical information, e.g. symbols, charts, function plots
• CPC Class Codes: Y10S 128/92 Computer assisted medical diagnostics

Abstract

A signal conditioning device is disclosed that interfaces a variety of sensor devices, such as guide wire-mounted pressure sensors, to physiology monitors. The signal conditioning device includes a processor for controlling sensor excitation and signal conditioning circuitry within the signal conditioning device. The processor also supplies signals to an output stage on the signal conditioning device representative of processed sensor signals received by a sensor interface of the signal conditioning device. Power for the signal conditioning device processor is supplied by an excitation signal received from a physiology monitor that drives the output stage. In addition, a temperature compensating current source provides an adjustment current to at least one of a pair of resistive sensor elements to compensate for differences between temperature change upon the pair of resistive sensor elements, thereby facilitating nullifying temperature effects upon the resistive sensor elements.

Claims

1. A signal conditioning device interposable between a physiology monitor and various intravascular measurement devices, the signal conditioning device facilitating establishing compatibility between the physiology monitor and the various intravascular measurement devices, the signal conditioning device comprising:

a sensor interface circuit supplying a sensor drive signal for energizing a sensor carried by an attachable intravascular measurement device and providing a sensor measurement signal;

a processing unit for performing programmed tasks;

a physiology monitor interface including;

an input for receiving an excitation signal from the physiology monitor, and

an output for transmitting an output measurement signal to the physiology monitor generated in accordance with the sensor measurement signal; and

a power supply circuit including a signal converter that energizes at least the processing unit with power supplied by the excitation signal.

2. The signal conditioning device of claim 1 wherein the excitation signal is an alternating current signal.

3. The signal conditioning device of claim 1 wherein the sensor interface circuit is configured to receive a cable for supplying the sensor drive signal for a pressure sensor mounted upon a flexible elongate member.

4. The signal conditioning device of claim 1 wherein a portion of power supplied by the excitation signal is received by an output stage that renders an analog signal.

5. The signal conditioning device of claim 1 further comprising a visual display powered by the excitation signal.

6. The signal conditioning device of claim 1 further comprising a temperature compensation circuit powered by the excitation signal.

7. The signal conditioning device of claim 1 wherein the excitation signal powers the sensor drive signal.

8. The signal conditioning device of claim 1 wherein the sensor interface circuit further comprises a connection for a cable that transmits the sensor drive signal to a solid-state intravascular pressure sensor.

9. The signal conditioning device of claim 1 wherein the power supply circuit is adapted to provide a non-distorting load to the excitation signal while receiving power.

10. The signal conditioning device of claim 1 wherein the excitation signal has a current of less than about 20 mA rms.

11. The signal conditioning device of claim 1 wherein the processing unit comprises a microcontroller.

12. The signal conditioning device of claim 1 wherein the programmed tasks performed by the processing unit include controlling generation of the sensor drive signal.

13. The signal conditioning device of claim 1 wherein the programmed tasks performed by the processing unit include configuring analog signal compensation circuitry.

14. The signal conditioning device of claim 1 wherein the programmed tasks performed by the processing unit include processing a digitized signal derived from the sensor measurement signal.

15. The signal conditioning device of claim 14 wherein the programmed tasks performed by the processing unit include rendering a digitally processed signal from the digitized signal, wherein the digitally processed signal drives the output measurement signal.

16. The signal conditioning device of claim 1 wherein the power supply circuit signal converter provides a current-regulated output.

17. The signal conditioning device of claim 1 wherein the power supply circuit receives non-filtered power input.

18. A system for taking a measurement from within a blood vessel to determine a flow characteristic within the blood vessel, the system comprising:

a flexible elongate member having a sensor mounted thereon;

a cable electrically connecting the sensor to a signal conditioning device wherein the signal conditioning device comprises;

a sensor interface circuit supplying a sensor drive signal for energizing a sensor carried by an attachable intravascular measurement device and providing a sensor measurement signal;

a processing unit for performing programmed tasks;

a physiology monitor interface including;

an input for receiving an excitation signal from the physiology monitor, and

an output for transmitting an output measurement signal to the physiology monitor generated in accordance with the sensor measurement signal; and

a power supply circuit including a signal converter that energizes at least the processing unit with power supplied by the excitation signal.

19. The system of claim 18 wherein the excitation signal is a square wave signal.

20. The system of claim 18 further comprising a handheld fractional flow reserve calculator.

21. The system of claim 20 wherein the handheld fractional flow reserve calculator comprises a slide-rule mechanism including at least a numerator scale corresponding to a first measured pressure and a denominator scale corresponding to a second measured pressure.

22. The system of claim 21 wherein the first measured pressure is a mean distal pressure, and wherein the second measured pressure is a mean aortic pressure.

23. The system of claim 22 wherein the slide-rule mechanism includes a set of directions for interpreting a calculated fractional flow reserve.

24. The signal conditioning device of claim 18 wherein the power supply circuit is adapted to provide an non-distorting load to the excitation signal while receiving power.

25. The signal conditioning device of claim 18 wherein the excitation signal has a current of less than about 20 mA rms.

26. The signal conditioning device of claim 18 wherein the processing unit comprises a microcontroller.

27. A method for assessing blood flow characteristics within a blood vessel by means of a signal conditioning device interposed between a physiology monitor and an intravascular sensor, the method comprising the steps of:

advancing the intravascular sensor to a target site within a patient'"'"'s vasculature;

providing an excitation signal with the physiology monitor that is used to power both the intravascular sensor and the signal conditioning device, the excitation signal having a current of less than about 20 mA rms;

measuring a physiological parameter with the intravascular sensor;

processing, by the signal conditioning device, physiological parameter measurements to render a conditioned measurement signal; and

transmitting a signal to the physiology monitor that corresponds to the conditioned measurement signal.

28. The method of claim 27 wherein measuring a physiological parameter further comprises measuring a mean distal pressure and measuring a mean aortic pressure across a stenosis, the method further comprising:

determining a fractional flow reserve with a slide-rule mechanism having a first scale representing mean distal pressure and a second scale representing mean aortic pressure.

29. The method of claim 27 wherein processing the physiological parameter measurements with the signal conditioning device comprises processing at least a portion of the measurements with a microcontroller.

30. The method of claim 27 further comprising:

calibrating the intravascular sensor to the signal conditioning device; and

calibrating the signal conditioning device to the physiology monitor.

31. A signal conditioning device interposable between an intravascular measurement device having a pair of resistive sensing elements, and a physiology monitor, the signal conditioning device facilitating establishing compatibility between the physiology monitor and the intravascular measurement device, the signal conditioning device comprising:

a sensor current source providing two separate excitation signals for independently driving the pair of resistive sensing elements of the intravascular measurement device;

a data input for receiving a temperature compensation calibration value for the intravascular measurement device; and

a variable current source providing an adjustment current to at least one of the pair of resistive sensing elements to compensate for temperature variations,

wherein the adjustment current is derived from the temperature compensation calibration value.

32. The signal conditioning device of claim 31 wherein the variable current source is powered by an excitation signal provided by the physiology monitor.

33. The signal conditioning device of claim 31 wherein the variable current source comprises a digital-to-analog converter.

34. The signal conditioning device of claim 31 wherein the intravascular measurement device comprises a pressure sensor of suitable dimensions to sense pressure from within a blood vessel.

35. A signal conditioning device interposable between a physiology monitor and various intravascular measurement devices, the signal conditioning device comprising:

a physiology monitor interface circuit having an input adapted to receive an excitation signal from the physiology monitor, and having an output adapted to transmit an output measurement signal to the physiology monitor;

a power supply circuit comprising a signal converter adapted to receive a portion of power supplied by the excitation signal;

a sensor interface circuit adapted to supply a sensor drive signal to a sensor carried by an attachable intravascular measurement device, the sensor interface circuit further adapted to provide a sensor measurement signal derived from the intravascular measurement device; and

a processing unit comprising a microcontroller, the processing unit adapted to render a digital sensor value, based upon the sensor measurement signal, and from which the output measurement signal is derived,

wherein the power supply circuit is adapted to power at least the processing unit with the portion of power supplied by the excitation signal.

36. The signal conditioning device of claim 35 wherein the excitation signal is less than about 20 mA rms.

37. The signal conditioning device of claim 35 wherein the signal converter receives an unfiltered input signal and renders a current-regulated output signal.

38. The signal conditioning device of claim 35 wherein the power supply circuit is adapted to provide a non-distorting load to the excitation signal while receiving the portion of power.