Thrombosis filter having a surface treatment

• US 6,589,266 B2
• Filed: 07/18/2001
• Issued: 07/08/2003
• Est. Priority Date: 08/10/1999
• Status: Expired due to Fees

• Current Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Original Assignee: Scimed Life Systems Incorporated (Boston Scientific Corporation)
• Inventors: Kaganov, Alan, Thornton, Sally C., Whitcher, Forrest D.
• Primary Examiner(s): Lewis; Ralph A.
• Application Number:
  US09/908,318
• Publication Number:
  US 20010039432A1
• Time in Patent Office: 720 Days
• Field of Search: 606/200,191,198
• US Class Current: 606/200
• CPC Class Codes: A61F 2/0105 Open ended, i.e. legs gathered only at one side
• CPC Class Codes: A61F 2002/016 made from wire-like elements
• CPC Class Codes: A61F 2230/005 Rosette-shaped, e.g. star-shaped
• CPC Class Codes: A61F 2230/0067 conical
• CPC Class Codes: A61F 2230/0078 hyperboloidal
• CPC Class Codes: A61F 2230/008 paraboloidal
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body

Abstract

A thrombosis filter configured for placement within a blood vessel lumen. The thrombosis filter of the present invention includes a body element, a plurality of struts, and a surface treatment. The surface treatment, comprised in part of an anti-proliferative or anti-angiogenic drug, is applied to portions of the thrombosis filter in order to regulate neointimal growth around the thrombosis filter and its anchor elements. The thrombosis filter may further contain a first and a second surface treatment layer. The first surface treatment layer possesses endothelial cell growth enhancing properties, while the second surface treatment layer includes the anti-proliferative or anti-angiogenic drug. The surface treatment may alternatively be applied to a substrate, which in turn is applied to the filter.

Claims

1. A thrombosis filter element for placement within a blood vessel lumen defined by a blood vessel wall, comprising:

a first body element;

a first strut having a joining end coupled to the first body element, and a free end adapted to engage the blood vessel wall;

a second body element coupled to the first body element;

a second strut having a joining end coupled to the second body element, and a free end adapted to engage the blood vessel wall; and

a surface treatment covering at least a portion of the thrombosis filter element, wherein the surface treatment comprises two layers, a first surface treatment layer located between a second surface treatment layer and the thrombosis filter, the first surface treatment layer having properties which enhance endothelial cell growth, and the second surface treatment layer including an anti-proliferative or anti-angiogenic drug.

2. A thrombosis filter element according to claim 1, wherein the first strut is comprised of materials selected from the group consisting of nitinol, stainless steel, tantalum, gold, silicone, and combinations thereof.

3. A thrombosis filter element according to claim 1, wherein the free end of the first strut terminates in a vessel-engaging tip portion.

4. A thrombosis filter element according to claim 3, wherein the vessel-engaging tip portion includes a sharpened portion and an adjacent flexible pad portion.

5. A thrombosis filter element according to claim 1, wherein the joining end of the first strut is coupled to the first body element by a hub.

6. A thrombosis filter element according to claim 1, wherein the drug includes taxol or a derivative of taxol.

7. A thrombosis filter element according to claim 1, wherein the drug includes phosphorylcholine.

8. A thrombosis filter element according to claim 1, wherein the drug is non-thrombogenic.

9. A thrombosis filter element according to claim 1, wherein the second surface treatment layer is dissolvable, wherein the dissolving rate may be varied depending upon the structure and composition of the second surface treatment layer.

10. A thrombosis filter element according to claim 1, wherein the first and second surface treatment layers cover the free end of the first strut.

11. A thrombosis filter element according to claim 1, wherein the surface treatments, or some combination of the first surface treatment layer and the second surface treatment layer, are coated upon at least a portion of the thrombosis filter element through a dipping or spraying process.

12. A thrombosis filter element for placement within a blood vessel lumen defined by a blood vessel wall, comprising:

a first body element;

a first strut having a joining end coupled to the first body element, and a free end adapted to engage the blood vessel wall;

wherein the free end of the first strut terminates in a vessel-engaging tip portion;

wherein the vessel-engaging tip portion includes a sharpened portion and an adjacent flexible pad portion; and

a surface treatment covering at least a portion of the thrombosis filter element, wherein the surface treatment comprises two layers, a first surface treatment layer located between a second surface treatment layer and the thrombosis filter, the first surface treatment layer having properties which enhance endothelial cell growth, and the second surface treatment layer including an anti-proliferative or anti-angiogenic drug.

13. A thrombosis filter element according to claim 12, further comprising a second body element and a second strut, the second body element coupled to the first body element, and the second strut having a joining end coupled to the second body element, and a free end adapted to engage the blood vessel wall.

14. A thrombosis filter element according to claim 12, wherein the first strut is comprised of materials selected from the group consisting of nitinol, stainless steel, tantalum, gold, silicone, and combinations thereof.

15. A thrombosis filter element according to claim 12, wherein the joining end of the first strut is coupled to the first body element by a hub.

16. A thrombosis filter element according to claim 12, wherein the drug includes taxol or a derivative of taxol.

17. A thrombosis filter element according to claim 12, wherein the drug includes phosphorylcholine.

18. A thrombosis filter element according to claim 12, wherein the drug is non-thrombogenic.

19. A thrombosis filter element according to claim 12, wherein the second surface treatment layer is dissolvable, wherein the dissolving rate may be varied depending upon the structure and composition of the second surface treatment layer.

20. A thrombosis filter element according to claim 12, wherein the first and second surface treatment layers cover the free end of the first strut.

21. A thrombosis filter element according to claim 12, wherein the surface treatments, or some combination of the first surface treatment layer and the second surface treatment layer, are coated upon at least a portion of the thrombosis filter element through a dipping or spraying process.

22. A thrombosis filter element for placement within a blood vessel lumen defined by a blood vessel wall, comprising:

a first body element;

a first strut having a joining end coupled to the first body element, and a free end adapted to engage the blood vessel wall;

a second body element coupled to the first body element;

a second strut having a joining end coupled to the second body element, and a free end adapted to engage the blood vessel wall; and

a surface treatment covering at least a portion of the thrombosis filter element;

wherein the surface treatment is applied to a substrate comprising a pad which is disposed about the free end of the first strut.

23. A thrombosis filter according to claim 22, wherein the pad includes a hole, and wherein the first strut is disposed in the hole.

24. A thrombosis filter element for placement within a blood vessel lumen defined by a blood vessel wall, comprising:

a first body element;

a first strut having a joining end coupled to the first body element, and a free end adapted to engage the blood vessel wall;

a second body element coupled to the first body element;

a second strut having a joining end coupled to the second body element, and a free end adapted to engage the blood vessel wall; and

a surface treatment covering at least a portion of the thrombosis filter element;

wherein the surface treatment is applied to a substrate comprising a tube which is disposed about the free end of the first strut.

25. A thrombosis filter according to claim 24, wherein the tube includes a lumen, and wherein the first strut is disposed in the lumen.

26. A thrombosis filter element for placement within a blood vessel lumen defined by a blood vessel wall, comprising:

a first body element;

a first strut having a joining end coupled to the first body element, and a free end adapted to engage the blood vessel wall;

a second body element coupled to the first body element;

a second strut having a joining end coupled to the second body element, and a free end adapted to engage the blood vessel wall; and

a surface treatment covering at least a portion of the thrombosis filter element;

wherein the surface treatment is applied to a substrate comprising a band surrounding the first strut when the thrombosis filter is in a collapsed configuration.

27. A thrombosis filter according to claim 26, wherein the band separates into a plurality of segments when the thrombosis filter is in an expanded configuration.