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Method for magnetic resonance imaging of the lung

  • US 6,589,506 B2
  • Filed: 03/28/2001
  • Issued: 07/08/2003
  • Est. Priority Date: 03/28/2000
  • Status: Expired due to Fees
First Claim
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1. A method for using a contrast agent for the assessment of the pulmonary ventilation and lung perfusion through MRI, wherein the contrast agent comprises a compound selected from the group consisting of superparamagnetic iron oxide nanoparticles (SPIO), ultrasmall superparamagnetic iron oxide nanoparticles (USPIO), gadolinium complexes and manganese complexes, and the method comprises:

  • (a) positioning a human subject in an MRI apparatus;

    (b) delivering a hyperpolarized noble gas to the subject by inhalation, followed by a breath-hold period, during which a bolus of said contrast agent is injected intravenously; and

    (c) acquiring, during said breath-hold period, at least one MR image of the lungs prior to said bolus intravenous injection and at least one MR image thereafter.

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