Anti-cancer therapy agent of arsenic hexoxide (As4O6) of a natural chemical substance and its pharmaceutical composition

• US 6,589,567 B2
• Filed: 09/14/2001
• Issued: 07/08/2003
• Est. Priority Date: 05/08/1998
• Status: Expired due to Term

• Current Assignee: Ill-Ju Bae
• Original Assignee: Ill-Ju Bae
• Inventors: Lee, Kwan-Hee, Park, Choon-Ho, Song, Seung-Kyu, Suh, Byung-Sun, Song, Byung-Doo, Kang, Tae-Bong, Kwak, Jin-Hwan, Eun, Choong-Ki, Kim, Jong-Bae, Yoon, Taek-Joon, Bae, Ill-Ju, Doo, Myoung-Sool
• Primary Examiner(s): Goldberg, Jerome D.
• Application Number:
  US09/951,393
• Publication Number:
  US 20020028253A1
• Time in Patent Office: 662 Days
• Field of Search: 424/623
• US Class Current: 424/623
• CPC Class Codes: A61K 33/36 Arsenic; Compounds thereof
• CPC Class Codes: A61P 31/00 Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 35/02 specific for leukemia

Abstract

This invention is about the identification of the HD-2, a natural chemical substance that was separated and purified from a natural product, Sinsuk, as arsenic hexoxide (As₄O₆) and about its therapeutic efficacy as an anti-cancer drug and pharmaceutical composition.

Arsenic hexoxide (As₄O₆), a natural chemical substance obtained from Sinsuk after eliminating the toxic property, has a potent anti-cancer efficacy by its direct cytotoxicity on tumor cells and suppresses the formation of new blood vessels of tumor masses, which results in complete cure of malignant cancers.

Claims

1. A pharmaceutical composition, comprising

a pharmaceutically effective amount of As₄O₆ and a pharmaceutically effective carrier, wherein said As₄O₆ is naturally derived from Sinsuk.