Particle delivery
First Claim
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1. A needleless syringe for accelerating particles into a target tissue surface of a vertebrate subject, said syringe comprising:
- (a) a body having a lumen therein, wherein said lumen has an upstream terminus and a downstream terminus and the upstream terminus of the lumen is capable of interfacing with an energizing means; and
(b) a diaphragm arranged adjacent to the downstream terminus of the lumen, said diaphragm having an internal surface facing the lumen and an external surface, wherein said diaphragm is moveable between an initial position in which a concavity is provided on the external surface of the diaphragm, and a dynamic position in which the external surface of the diaphragm is substantially convex, characterized in that the external surface of said diaphragm comprises one or more topographical features which selectively retain particles on the external surface of the diaphragm when in its initial position.
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Abstract
A needleless syringe capable of accelerating particles into a target surface is provided. The syringe comprises a body having a lumen with a diaphragm located adjacent to a terminus thereof. Particles are delivered from an external surface of the diaphragm by means of the motive force provided by the impact of a shockwave imparted to the internal surface of the diaphragm. A method for delivering particles from the needleless syringe is also provided.
62 Citations
17 Claims
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1. A needleless syringe for accelerating particles into a target tissue surface of a vertebrate subject, said syringe comprising:
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(a) a body having a lumen therein, wherein said lumen has an upstream terminus and a downstream terminus and the upstream terminus of the lumen is capable of interfacing with an energizing means; and
(b) a diaphragm arranged adjacent to the downstream terminus of the lumen, said diaphragm having an internal surface facing the lumen and an external surface, wherein said diaphragm is moveable between an initial position in which a concavity is provided on the external surface of the diaphragm, and a dynamic position in which the external surface of the diaphragm is substantially convex, characterized in that the external surface of said diaphragm comprises one or more topographical features which selectively retain particles on the external surface of the diaphragm when in its initial position. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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Specification