Partial aortic occlusion devices and methods for cerebral perfusion augmentation

• US 6,592,557 B2
• Filed: 03/09/2001
• Issued: 07/15/2003
• Est. Priority Date: 03/01/1999
• Status: Expired due to Term

• Current Assignee: Zoll Circulation Incorporated (Asahi Kasei Corporation)
• Original Assignee: Coaxis Incorporated (Trimble Inc.)
• Inventors: Barbut, Denise R.
• Primary Examiner(s): Mendez, Manuel
• Assistant Examiner(s): Thompson, Michael M
• Application Number:
  US09/802,822
• Publication Number:
  US 20010041860A1
• Time in Patent Office: 858 Days
• Field of Search: 604/96.01, 604/22, 604/507, 604/509, 604/98.01, 604/101-1-1, 604/236, 604/532, 604/915, 604/919, 606/159, 606/194, 606/198, 606/200, 600/468, 600/485-488, 600/587, 128/207.15
• US Class Current: 604/236
• CPC Class Codes: A61B 17/12022 Occluding by internal devices, e.g. balloons or releasable wires plugging an opening in the wall of an organ A61B17/0057; occluders for the cervical canal A61F6/146; vas deferens occluders A61F6/20
• CPC Class Codes: A61B 17/12036 partial occlusion
• CPC Class Codes: A61B 17/12099 characterised by the location of the occluder
• CPC Class Codes: A61B 17/12109 in a blood vessel
• CPC Class Codes: A61B 17/12136 Balloons
• CPC Class Codes: A61B 17/12172 having a pre-set deployed three-dimensional shape methods of manufacturing A61B2017/00526
• CPC Class Codes: A61B 5/0215 by means inserted into the body catheters A61M25/00
• CPC Class Codes: A61B 5/4064 Evaluating the brain A61B5/031, A61B5/369, A61B5/14553 take precedence
• CPC Class Codes: A61B 5/4076 Diagnosing or monitoring particular conditions of the nervous system A61B5/4821, A61B5/4824 take precedence
• CPC Class Codes: A61M 2025/0073 Tip designed for influencing the flow or the flow velocity of the fluid, e.g. inserts for twisted or vortex flow general flow characteristics A61M2206/10
• CPC Class Codes: A61M 2025/1052 for temporarily occluding a vessel for isolating a sector
• CPC Class Codes: A61M 2210/127 Aorta
• CPC Class Codes: A61M 2230/30 Blood pressure A61M2230/04 takes precedence
• CPC Class Codes: A61M 25/00 Catheters; Hollow probes dilators A61M29/00; peritoneal catheters A61M1/285; tracheal tubes A61M16/04; for drainage A61M27/00; for uterus, vagina or rectum A61M31/00 ; for measuring or testing A61B; materials for catheters A61L29/00
• CPC Class Codes: A61M 25/0074 Dynamic characteristics of the catheter tip, e.g. openable, closable, expandable or deformable
• CPC Class Codes: A61M 25/0082 Catheter tip comprising a tool
• CPC Class Codes: A61M 25/0662 Guide tubes

Abstract

Methods are provided for partial aortic occlusion for cerebral perfusion augmentation in patients suffering from global or focal cerebral ischemia. Alternatively, the methods can be used to partially occlude aortic blood flow to condition the spinal cord to secrete neuroprotective agents prior to abdominal aortic aneurysm repair. The methods can also be used to partially occlude the renal arteries to reduce renin secretion in hypertensive patients. Partial occlusion of a vessel can be accomplished by a device comprising an elongate catheter, a distally mounted expandable occluder, a variable flow mechanism, and a manometer. The occluder may comprise two conical shells or an inflatable ring-shaped balloon disposed about a cylindrical sleeve. Other medical devices, such as an atherectomy catheter, can be inserted distal the occluder to provide therapeutic intervention.

Claims

1. A medical device for partial aortic occlusion for cerebral perfusion augmentation, comprising:

an elongate member having proximal and distal ends, the distal end adapted for insertion through a peripheral artery into the descending aorta;

a balloon mounted at a distal region of the elongate member, the balloon being expandable to reduce blood flow in the aorta and adjustable during use to increase or reduce blood flow in the aorta;

a catheter extending through a lumen of the elongate member and independently operable to access any of the carotid arteries, the coronary arteries, the aortic wall, and the conducting tissue of the heart and myocardium, the catheter carrying a medical device; and

a pressure measuring mechanism attached to the elongate member distal the balloon for measuring blood pressure in the aorta,

wherein, during use, the balloon is expanded, blood pressure upstream of the balloon is increased, and cerebral blood flow is increased.

2. The device of claim 1, wherein the distal end of the elongate member is adapted for insertion through the femoral artery.

3. The device of claim 1, wherein the pressure measuring device comprises a manometer mounted distal the balloon.

4. The device of claim 1, wherein the balloon is expandable to engage the lumen of the aorta and wherein the balloon has one or mote passages adjustable independently of the expansion of the balloon through which distal blood flow may be carried.

5. The device of claim 4, further comprising a variable flow mechanism in operative association with the adjustable passages for controlling blood flow through the passages.

6. The device of claim 2, wherein the catheter includes aspiration capabilities.

7. The device of claim 2, wherein the medical device is an atherectomy catheter.

8. The device of claim 2, wherein the medical device is an infusion catheter.

9. The device of claim 2, wherein the medical device is an EPS catheter.