Capillary electrophoresis devices incorporating optical waveguides

• US 6,592,733 B1
• Filed: 11/12/1999
• Issued: 07/15/2003
• Est. Priority Date: 11/12/1999
• Status: Expired due to Fees

• Current Assignee: Waters Technologies Corporation (Waters Corporation)
• Original Assignee: Motorola, Inc. (Motorola Solutions, Inc.)
• Inventors: Foley, Barbara, Sawyer, Jaymie, Briscoe, Cynthia G.
• Primary Examiner(s): Nguyen, Nam
• Assistant Examiner(s): STARSIAK, JOHN S
• Application Number:
  US09/438,873
• Time in Patent Office: 1,341 Days
• Field of Search: 204/603, 204/452, 356/344, 250/458.1, 250/459.1, 250/461.1, 250/461.2, 250/573, 250/575
• US Class Current: 204/603
• CPC Class Codes: G01N 27/44721 by optical means
• CPC Class Codes: G01N 27/44782 of a plurality of samples
• CPC Class Codes: G01N 27/44791 Microapparatus sample containers with integrated microfluidic structures B01L3/5027

Abstract

A capillary electrophoresis device having a substrate layer and a cover layer, with a plurality of electrophoresis channels formed in the substrate layer, includes an optical waveguide system that transmits excitation radiation from a source port into each one of the electrophoresis channels. The optical waveguide system is defined by regions, within either the cover or substrate, that have an index of refraction higher than that of the surrounding material.

Claims

1. A capillary electrophoresis devise comprising:

a substrate, said substrate having a plurality of electrophoresis channels formed therein;

an optical waveguide system having at least one of a source port and a plurality of output ports, wherein said optical waveguide system is suitably adapted to effectively transmit light entering said source port into each of said electrophoresis channels through at least one of said output ports;

said optical waveguide system further comprising at least one of a source segment and a plurality of intermediate segments, said source segment comprising at least one of said source port and one of said output ports, each one of said intermediate segments comprising at least one of an input port and one of said output ports, wherein each one of said input ports is suitably adapted to effectively receive light transmitted substantially through one of said electrophoresis channels by at least one of said output ports; and

each one of said output ports suitably shaped so as to focus light in at least of said electrophoresis channels.

2. The capillary electrophoresis device of claim 1, wherein each of said input ports is suitably shaped so as to effectively gather light substantially focused by at least one of said output ports.

3. A capillary electrophoresis device comprising:

a substrate, said substrate having a plurality of electrophoresis channels formed therein;

an optical waveguide system having at least one of a source port and a plurality of output ports, wherein said optical waveguide system is suitably adapted to effectively transmit light entering said source port into each of said electrophoresis channels through at least one of said output ports; and

a cover attached to said substrate, at least a portion of said optical waveguide system being disposed in said cover.

4. The capillary electrophoresis device of claim 3, wherein said optical waveguide system is substantially integral with said cover, said optical waveguide system at least partially defined by suitably high index of refraction regions substantially within said cover.

5. The capillary electrophoresis device of claim 4, wherein at least one of said output ports comprises a grating.