System and method for biochemical assay
First Claim
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1. A system for making a biochemical assay of each of a plurality of provided specimens, the system comprising:
- a. a plurality of receptacles, each receptacle containing a respective specimen of the plurality of specimens, each receptacle comprising a surface for binding a paramagnetic particle to the surface;
b. a detector for providing a resistance responsive to paramagnetic particle proximity to the detector in accordance with a giant magnetoresistive effect;
c. a mechanism for positioning each respective surface in working proximity to the detector for providing a respective resistance; and
d. a controller for controlling the mechanism and for recording indicia of each respective resistance;
wherein the detector comprises a multiplicity of physically defined active areas for independent detecting of each of a corresponding multiplicity of specimens of the plurality of specimens;
each active area comprises a plurality of sensors each sensor comprising an independent resistance responsive to paramagnetic particle proximity to the respective sensor in accordance with a respective giant magnetoresistive effect; and
the controller further records indicia of each sensor;
said plurality of sensors is arranged in an array coupled to a differential amplifier, said array is addressed by a row ring counter; and
a column ring counter;
each addressed cell is coupled in turn in a bridge circuit to said differential amplifier;
said differential amplifier provides a signal that conveys indicia of the resistance of each sensor according to a sequence.
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Abstract
A system for making a biochemical assay of each of plurality of provided specimens, comprising: a plurality of receptacles, a sensor for providing a resistance, a mechanism and a controller.
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Citations
1 Claim
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1. A system for making a biochemical assay of each of a plurality of provided specimens, the system comprising:
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a. a plurality of receptacles, each receptacle containing a respective specimen of the plurality of specimens, each receptacle comprising a surface for binding a paramagnetic particle to the surface;
b. a detector for providing a resistance responsive to paramagnetic particle proximity to the detector in accordance with a giant magnetoresistive effect;
c. a mechanism for positioning each respective surface in working proximity to the detector for providing a respective resistance; and
d. a controller for controlling the mechanism and for recording indicia of each respective resistance;
wherein the detector comprises a multiplicity of physically defined active areas for independent detecting of each of a corresponding multiplicity of specimens of the plurality of specimens;
each active area comprises a plurality of sensors each sensor comprising an independent resistance responsive to paramagnetic particle proximity to the respective sensor in accordance with a respective giant magnetoresistive effect; and
the controller further records indicia of each sensor;
said plurality of sensors is arranged in an array coupled to a differential amplifier, said array is addressed by a row ring counter; and
a column ring counter;
each addressed cell is coupled in turn in a bridge circuit to said differential amplifier;
said differential amplifier provides a signal that conveys indicia of the resistance of each sensor according to a sequence.
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Specification
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Current AssigneeBIO-Spectrum Technologies, Inc.
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Original AssigneeBIO-Spectrum Technologies, Inc.
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InventorsHardman, Clayton M., Mishra, Sanjay R., Sra, Kuldip, Mahal, Jaspal
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Primary Examiner(s)Soderquist, Arlen
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Application NumberUS09/186,793Time in Patent Office1,713 DaysField of Search422/63, 422/65, 422/67, 422/100, 422/101, 422/104, 436/43, 436/47, 436/48, 436/49, 436/54, 436/174, 436/175, 436/180, 436/514, 436/526, 436/528, 209/213, 209/215, 210/222, 210/233US Class Current422/65CPC Class CodesG01N 27/745 for detecting magnetic bead...G01N 35/0098 involving analyte bound to ...Y10T 436/11 Automated chemical analysisY10T 436/113332 with conveyance of sample a...Y10T 436/119163 with aspirator of claimed s...
