Photonic molecular probe
First Claim
1. An opto-electronic device utilizing a band of partially polarized polychromatic light for quantitative analysis of a specimen containing a target molecule, the device comprising:
- a polarizer for producing a segmented band of partially polarized polychromatic light from the band of partially polarized polychromatic light;
a specimen cell adapted for receiving the specimen and for transporting the segmented band of partially polarized polychromatic light to the specimen;
a polarizing analyzer optically coupled to the segmented band of partially polarized polychromatic light exiting the specimen; and
comparison means for comparing the segmented band of partially polarized polychromatic light before entering the specimen with the segmented band of partially polarized polychromatic light after exiting the specimen, the comparison means comprises an optical sensor and a signal processor for determining a quantitative level of the target molecule within the specimen;
wherein the target molecule changes ellipticity of the segmented band of partially polarized polychromatic light.
1 Assignment
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Accused Products
Abstract
An opto-electronic device utilizes a band of polychromatic light for quantitative analysis of a target molecule within a mixed specimen. A movable polarizer produces a segmented band of partially polarized polychromatic light from the band of partially polarized polychromatic light. A specimen cell adapted for receiving the mixed specimen transports the segmented band of partially polarized polychromatic light to the mixed specimen. A movable polarizing analyzer is optically coupled to the segmented band of partially polarized polychromatic light exiting the mixed specimen. The segmented band of partially polarized polychromatic light before entering the mixed specimen is compared with the segmented band of partially polarized polychromatic light after exiting the mixed specimen. The movable polarizer is synchronized with the movable polarizing analyzer. Additionally a frequency filter can be optically coupled to the movable polarizer, where the frequency filter produces a beam of single frequency ellipitically polarized light from the band of partially polarized polychromatic light such that the segmented band of partially polarized polychromatic light is a segmented band of ellipitically polarized light.
51 Citations
40 Claims
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1. An opto-electronic device utilizing a band of partially polarized polychromatic light for quantitative analysis of a specimen containing a target molecule, the device comprising:
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a polarizer for producing a segmented band of partially polarized polychromatic light from the band of partially polarized polychromatic light;
a specimen cell adapted for receiving the specimen and for transporting the segmented band of partially polarized polychromatic light to the specimen;
a polarizing analyzer optically coupled to the segmented band of partially polarized polychromatic light exiting the specimen; and
comparison means for comparing the segmented band of partially polarized polychromatic light before entering the specimen with the segmented band of partially polarized polychromatic light after exiting the specimen, the comparison means comprises an optical sensor and a signal processor for determining a quantitative level of the target molecule within the specimen;
wherein the target molecule changes ellipticity of the segmented band of partially polarized polychromatic light. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A method for quantitative analysis of a target molecule within a specimen, the method comprising the steps of:
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producing elliptical/partially polarized polychromatic light;
producing segmented characterized light with a polarizer optically coupled to the elliptical/partially polarized polychromatic light;
transporting the segmented characterized light onto and through the specimen;
polarizing the segmented characterized light exiting the specimen; and
comparing the segmented characterized light before entering the specimen with the segmented characterized light after exiting the specimen to determine a quantitative level of the target molecule within the specimen, wherein the target molecule changes ellipticity of the segmented characterized light and the quantitative level of the target molecule within the specimen is a glucose level.
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16. A method for quantitative analysis of a target molecule within a specimen, the method comprising the steps of:
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producing elliptical/partially polarized polychromatic light;
producing segmented characterized light with a polarizer optically coupled to the elliptical/partially polarized polychromatic light;
transporting the segmented characterized light onto and through the specimen;
polarizing the segmented characterized light exiting the specimen; and
comparing the segmented characterized light before entering the specimen with the segmented characterized light after exiting the specimen to determine a quantitative level of the target molecule within the specimen, transporting the segmented characterized light onto and through the specimen;
polarizing the segmented characterized light exiting the specimen; and
comparing the segmented characterized light before entering the specimen with the segmented characterized light after exiting the specimen to determine a quantitative level of the target molecule within the specimen, wherein the target molecule changes ellipticity of the segmented characterized light and the quantitative level of the target molecule within the specimen is a hormone serum level.
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17. A method for quantitative analysis of a target molecule within a specimen, the method comprising the steps of:
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producing elliptical/partially polarized polychromatic light;
producing segmented characterized light with a polarizer optically coupled to the elliptical/partially polarized polychromatic light;
transporting the segmented characterized light onto and through the specimen;
polarizing the segmented characterized light exiting the specimen; and
comparing the segmented characterized light before entering the specimen with the segmented characterized light after exiting the specimen to determine a quantitative level of the target molecule within the specimen, wherein the target molecule changes ellipticity of the segmented characterized light and the quantitative level of the target molecule within the specimen is a hormone serum level.
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18. A method for quantitative analysis of a target molecule within a specimen, the method comprising the steps of:
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producing elliptical/partially polarized polychromatic light;
producing segmented characterized light with a polarizer optically coupled to the elliptical/partially polarized polychromatic light;
transporting the segmented characterized light onto and through the specimen;
polarizing the segmented characterized light exiting the specimen; and
comparing the segmented characterized light before entering the specimen with the segmented characterized light after exiting the specimen to determine a quantitative level of the target molecule within the specimen, wherein the target molecule changes ellipticity of the segmented characterized light and the quantitative level of the target molecule within the specimen is a hormone serum level.
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19. A method for quantitative analysis of a target molecule within a specimen, the method comprising the steps of:
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producing elliptical/partially polarized polychromatic light;
producing segmented characterized light with a polarizer optically coupled to the elliptical/partially polarized polychromatic light;
transporting the segmented characterized light onto and through the specimen;
polarizing the segmented characterized light exiting the specimen; and
comparing the segmented characterized light before entering the specimen with the segmented characterized light after exiting the specimen to determine a quantitative level of the target molecule within the specimen, wherein the target molecule changes ellipticity of the segmented characterized light and the quantitative level of the target molecule within the specimen is a triglycerides level.
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20. An opto-electronic device utilizing a band of partially polarized polychromatic light for quantitative analysis of a specimen containing various target molecules, the device comprising:
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a polarizer for producing a segmented band of partially polarized polychromatic light from the band of partially polarized polychromatic light;
a specimen cell adapted for receiving the specimen and for transporting the segmented band of partially polarized polychromatic light to the specimen;
a polarizing analyzer optically coupled to the segmented band of partially polarized polychromatic light exiting the specimen; and
comparison means for comparing the segmented band of partially polarized polychromatic light before entering the specimen with the segmented band of partially polarized polychromatic light after exiting the specimen, wherein each target molecule of the various target molecules distinctly changes ellipticity of the segmented band of partially polarized polychromatic light as a function of concentration of the target molecule. - View Dependent Claims (21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34)
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35. A method for quantitative analysis of various target molecules within a specimen, the method comprising the steps of:
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producing elliptical/partially polarized polychromatic light;
producing segmented characterized light with a polarizer optically coupled to the elliptical/partially polarized polychromatic light;
transporting the segmented characterized light onto and through the specimen;
polarizing the segmented characterized light exiting the specimen; and
comparing the segmented characterized light before entering the specimen with the segmented characterized light after exiting the specimen to determine a quantitative level of at least one of the various target molecules within the specimen, wherein each target molecule of the various target molecules distinctly changes ellipticity of the segmented characterized light as a function of concentration of the target molecule. - View Dependent Claims (36, 37, 38, 39, 40)
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Specification