Topical delivery of vaccines

• US 6,595,947 B1
• Filed: 05/22/2000
• Issued: 07/22/2003
• Est. Priority Date: 05/22/2000
• Status: Expired due to Term

• Current Assignee: Becton, Dickinson & Co
• Original Assignee: Becton, Dickinson & Co
• Inventors: Mikszta, John A., Dekker, John P. III, Brittingham, John M., Alarcon, Jason, Pettis, Ronald J.
• Primary Examiner(s): Walberg, Teresa
• Assistant Examiner(s): FASTOVSKY, LEONID M
• Application Number:
  US09/576,643
• Time in Patent Office: 1,156 Days
• Field of Search: 604/27, 604/896, 604/501, 604/506, 604/890.1, 600/372, 600/550, 606/131, 424/449, 264/313
• US Class Current: 604/27
• CPC Class Codes: A61B 17/205 Vaccinating by means of needles or other puncturing devices
• CPC Class Codes: A61K 9/0021 Intradermal administration, e.g. through microneedle arrays, needleless injectors mechanical aspects A61M
• CPC Class Codes: A61M 2037/0046 Solid microneedles
• CPC Class Codes: A61M 2037/0061 Methods for using microneedles
• CPC Class Codes: A61M 37/00 Other apparatus for introducing media into the body for reproduction or fertilisation A61B17/425; apparatus for iontophoresis or cataphoresis A61N1/30; Percutany, i.e. introducing medicines into the body by diffusion through the skin salt baths A61H33/04
• CPC Class Codes: A61M 37/0015 by using microneedles

Abstract

A method for delivering a substance to the epidermal tissue of skin. The method involves simultaneously disrupting only the stratum corneum of the skin and delivering the substance to the epidermal tissue of the skin.

Claims

1. A method for a single and immediate delivery of a substance to the epidermal tissue of skin comprising simultaneously disrupting only the stratum corneum but not the epidermis of the skin and delivering the substance to the epidermal tissue of the skin.

2. The method of claim 1 wherein the substance is a nucleic acid.

3. The method of claim 2 wherein the nucleic acid encodes an antigen.

4. The method of claim 3 wherein expression of the antigen produces an immune response.

5. The method of claim 1 wherein the substance is an amino acid, amino acid derivative, peptide or polypeptide.

6. The method of claim 5 wherein the substance is an allergen.

7. The method of claim 1 wherein the skin is abraded at least twice.

8. The method of claim 7 wherein the skin is abraded at least six times.

9. The method of claim 8 wherein the skin is abraded six to twelve times.

10. The method of claim 1 wherein the skin is abraded in alternating directions.

11. The method of claim 1 wherein the substance is applied to the skin in liquid form.

12. The method of claim 11 wherein the substance is applied to the skin from an abrading device.

13. The method of claim 11 wherein the substance is applied to the skin prior to abrasion.

14. The method of claim 1 wherein a dry substance is reconstituted simultaneously with abrasion.

15. The method of claim 14 wherein the substance is a powder on an abrading surface of an abrading device.

16. The method of claim 15 wherein a reconstituting liquid is separately applied to the skin prior to abrading.

17. The method of claim 15 wherein a reconstituting liquid is applied to the skin simultaneously with abrading.

18. The method of claim 1 wherein the skin is abraded using a device comprising a microneedle array.

19. A device for delivering a substance into skin comprising an abrading surface coated with the substance and a reservoir containing a reconstituting liquid in fluid communication with the abrading surface.

20. The device of claim 19 wherein the abrading surface is a microneedle array.

21. The device of claim 20 wherein the substance is coated on the microneedles.

22. The device of claim 19 wherein the reservoir communicates with the abrading surface via channels through protrusions on the abrading surface.

23. The device of claim 19 wherein the reservoir communicates with the abrading surface via channels between protrusions on the abrading surface.

24. The device of claim 19 wherein the reservoir communicates with the abrading surface by means of a porous material between the reservoir and the abrading surface.

25. The device of claim 19 wherein the substance is a nucleic acid, amino acid, amino acid derivative, peptide or polypeptide.