Composition for the treatment and prevention of endothelial dysfunction

• US 6,596,708 B1
• Filed: 09/07/2001
• Issued: 07/22/2003
• Est. Priority Date: 09/07/2001
• Status: Active Grant

• Current Assignee: Advanced Medical Instruments
• Original Assignee: Advanced Medical Instruments
• Inventors: Petrus, Edward J.
• Primary Examiner(s): Wilson, James O.
• Assistant Examiner(s): FISHER, LA TONIA M
• Application Number:
  US09/947,674
• Time in Patent Office: 683 Days
• Field of Search: 424/643, 514/62, 514/641, 514/617, 514/165, 514/168, 514/251
• US Class Current: 514/62
• CPC Class Codes: A61K 31/525 Isoalloxazines, e.g. riboflavins, vitamin B2
• CPC Class Codes: A61K 31/60 Salicylic acid; Derivatives thereof
• CPC Class Codes: A61K 31/70 Carbohydrates; Sugars; Derivatives thereof sorbitol A61K31/047

Abstract

A composition for the treatment and prevention of endothelial dysfunction comprising a therapeutically effective amount of anti-inflammatory agents comprising; acetylsalicylic acid, an amino sugar and a zinc compound.

Claims

1. A composition for the treatment and prevention of endothelial dysfunction in mammals comprising a therapeutically effective amount of anti-inflammatory agents comprising;

acetylsalicylic acid, an amino sugar and a zinc compound.

2. The acetylsalicylic acid of claim 1, is micropulverized.

3. The amino sugar of claim 1, is selected from a group comprising;

glucosamine, glucosamine hydrochloride, glucosamine sulfate, N-acetylglucosamine and mixtures thereof.

4. The zinc compound of claim 1, is selected from a group comprising;

zinc sulfate, zinc chloride, zinc acetate, zinc phenol sulfonate, zinc borate, zinc bromide, zinc nitrate, zinc glycerophosphate, zinc benzoate, zinc carbonate, zinc citrate, zinc hexafluorosilicate, zinc diacetate trihydrate, zinc oxide, zinc peroxide, zinc salicylate, zinc silicate, zinc stannate, zinc tannate, zinc titanate, zinc tetrafluoroborate, zinc gluconate, and zinc glycinate.

5. The composition of claim 1, is in the form of a powder to accelerate local and systemic absorption.

6. The composition of claim 1, is optionally delivered in the form of a rapidly disintegrating tablet.

7. A composition for the treatment and prevention of endothelial dysfunction in mammals comprising a therapeutically effective amount of anti-inflammatory agents comprising;

acetylsalicylic acid, a second NSAID, an amino sugar, and a zinc compound.

8. The acetylsalicylic acid of claim 7, is micropulverized.

9. The second NSAID of claim 7, is selected from a group comprising;

ibuprofen, naproxen and ketoprofer.

10. The amino sugar of claim 7, is selected from a group comprising;

glucosamine, glucosamine hydrochloride, glucosamine sulfate, N-acetylglucosamine and mixtures thereof.

11. The zinc compound of claim 7, is selected from a group comprising;

zinc sulfate, zinc chloride, zinc acetate, zinc phenol sulfonate, zinc borate, zinc bromide, zinc nitrate, zinc glycerophosphate, zinc benzoate, zinc carbonate, zinc citrate, zinc hexafluorosilicate, zinc diacetate trihydrate, zinc oxide, zinc peroxide, zinc salicylate, zinc silicate, zinc stannate, zinc tannate, zinc titanate, zinc tetrafluoroborate, zinc gluconate, and zinc glycinate.

12. The composition of claim 7, is delivered in the form of a powder to accelerate local and systemic absorption.

13. The composition of claim 7, is optionally delivered in the form of a rapidly disintegrating tablet.

14. A method for the treatment and prevention of endothelial dysfunction in mammals by administering a therapeutically effective amount of anti-inflammatory agents comprising;

acetylsalicylic acid, an amino sugar and a zinc compound.

15. The method of claim 14, so that the acetylsalicylic acid is micropulverized.

16. The method of claim 14, so that the amino sugar is selected from a group comprising;

glucosamine, glucosamine hydrochloride, glucosamine sulfate, N-acetylglucosamine and mixtures thereof.

17. The method of claim 14, so that the zinc compound is selected from a group comprising;

zinc sulfate, zinc chloride, zinc acetate, zinc phenol sulfonate, zinc borate, zinc bromide, zinc nitrate, zinc glycerophosphate, zinc benzoate, zinc carbonate, zinc citrate, zinc hexafluorosilicate, zinc diacetate trihydrate, zinc oxide, zinc peroxide, zinc salicylate, zinc silicate, zinc stannate, zinc tannate, zinc titanate, zinc tetrafluoroborate, zinc gluconate, and zinc glycinate.

18. The method of claim 14, so that the composition is delivered in the form of a powder to accelerate local and systemic absorption.

19. The method of claim 14, so that the composition is optionally delivered in the form of a rapidly disintegrating tablet.

20. The method of claim 14, wherein the composition may contain one or more active agents selected from a group consisting of;

flavorings, sweeteners, pigments, antioxidants, antibacterial agents, bismuth compounds, and anti-inflammatory agents.