Methods of detecting occlusion of the coronary artery system and imaging the heart

• US 6,597,940 B2
• Filed: 11/30/2001
• Issued: 07/22/2003
• Est. Priority Date: 12/01/2000
• Status: Expired due to Term

• Current Assignee: Neomed Technologies, LLC, Neose Technologies, Inc.
• Original Assignee: Neose Technologies, Inc.
• Inventors: Majewski, Stanislaw, Umeno, Marc M., Bishop, Harry
• Primary Examiner(s): Lateef, Marvin M.
• Assistant Examiner(s): Pass, Barry
• Application Number:
  US09/996,602
• Publication Number:
  US 20020068864A1
• Time in Patent Office: 599 Days
• Field of Search: 600/407, 600/431, 600/436, 250/367, 250/366, 250/370
• US Class Current: 600/436
• CPC Class Codes: A61B 5/02755 Radioactive tracers
• CPC Class Codes: A61B 6/4258 for detecting non x-ray radiation, e.g. gamma radiation A61B6/037 takes precedence
• CPC Class Codes: A61B 6/507 for determination of haemodynamic parameters, e.g. perfusion CT
• CPC Class Codes: G01T 1/1644 using an array of optically separate scintillation elements permitting direct location of scintillations G01T1/1645 takes precedence

Abstract

One aspect of the present invention relates to screening patients for an early stage of coronary artery disease. According to this method, a patient is screened based on the time-activity curve for a radioactive tracer passing through a left ventricle region of the patient'"'"'s body. According to another aspect of the invention, an array of gamma particle detectors is employed to obtain data for a region of interest that is larger than and encompasses a left ventricle region of the patient'"'"'s body. An analysis of the data identifies the subset of the region of interest that corresponds to the left ventricle region. According to a further aspect of the present invention, a second technique is employed to locate the left ventricle region. A still further aspect of the present invention relates to obtaining images of a patient'"'"'s heart using a high temporal resolution gamma camera.

Claims

1. A method of detecting partial occlusion of a coronary circulation system in a patient having a bloodstream, comprising:

injecting the bloodstream with a bolus comprising a radioactive tracer;

obtaining measurements related to a time variation in concentration of the radioactive tracer for a plurality of adjacent regions in the patient that encompass an area greater than a left ventricle region;

determining a subset of the plurality of regions that correspond to the left ventricle region; and

assessing whether the coronary circulation system is partially occluded based at least in part on those of the measurements that correspond to the left ventricle region.

2. The method of claim 1, wherein the measurements are obtained with one or more gamma particle detectors comprising a scintillator array and one or more photo-multipliers.

3. The method of claim 2, wherein the measurements are obtained with one or more position-sensitive photo-multipliers.

4. The method of claim 2, wherein the measurements are obtained with electronics that process output from the one or more photo-multipliers in parallel.

5. The method of claim 1, wherein the measurements further correspond to a first pass of the bolus through the left ventricle region.

6. The method of claim 5, wherein the assessment is based on a time variation in concentration of the tracer in the left ventricle region as a whole.

7. The method of claim 1, wherein the assessment is based on a time variation in concentration of the tracer in the left ventricle region as a whole.

8. The method of claim 1, wherein the tracer does not absorb on vessel walls.

9. The method of claim 1, wherein the assessment is made without stressing the patient.

10. A method of detecting an early stage of occlusive coronary artery disease in a patient having a bloodstream and a heart having a left ventricle, comprising:

determining the location of the heart by at least one of ultrasound, MRI, x-ray, computed tomography, planar nuclear medicine, positron emission spectroscopy, single photon emission computed tomography;

using the determined location of the heart to position a gamma camera to detect gamma particles emitted from an area greater than a left ventricle region of the patient;

injecting the bloodstream with a bolus comprising a first radioactive tracer;

using the gamma camera to obtain measurements related to a time variation in concentration of the first radioactive tracer for a plurality of adjacent regions in the patient that encompass an area greater than the left ventricle region;

determining a subset of the plurality of regions that correspond to the left ventricle region; and

assessing whether the coronary circulation system is partially occluded based on at least in part on those of the measurements that correspond to the left ventricle region.

11. The method of claim 10, wherein the position of the heart is determined by ultrasound.

12. The method of claim 10, wherein the position of the heart is determined by a process involving the detection of a second radioactive tracer, which is different from the first radioactive tracer.

13. A method of screening a patient for an early stage of coronary artery disease, comprising:

injecting the patient with a bolus comprising a radioactive tracer;

measuring a first time variation in a concentration of the radioactive tracer in a left ventricle region of the patient;

measuring a second time variation in the concentration of the radioactive tracer in a second region of the patient located downstream of the left ventricle region; and

comparing the first time variation and the second time variation to screen the patient for coronary artery disease, including some stages of the disease occurring before the onset of inducible myocardial ischemia.

14. The method of claim 13, further comprising:

measuring a second time variation in a concentration of the radioactive tracer in a second portion of the patient located downstream of the left ventricle region; and

computing a CTI from the first time variation and the second time variation and using the CTI to screen the patient for the early stage of coronary artery disease.

15. The method of claim 13, wherein the first time variation corresponds to a first pass of the bolus through the left ventricle region.

16. The method of claim 15, wherein the left ventricle region includes the entire left ventricle.

17. The method of claim 13, wherein the left ventricle region includes the entire left ventricle.

18. The method of claim 13, wherein the tracer does not absorb on vessel walls.

19. The method of claim 13, wherein screening is accomplished without stressing the patient.

20. A method of detecting coronary artery disease, comprising:

injecting the bloodstream with a bolus comprising a radioactive tracer;

employing a first gamma particle detector to determine the bolus shape as it passes a point upstream of a heart;

determining whether the bolus shape is satisfactory for a bolus transit time measurement; and

if the bolus shape is satisfactory, measuring the bolus transit time with a second gamma particle detector and detecting coronary artery disease from the bolus transit time.