Method of using spectral measures to distinguish among atrialfibrillation, atrial-flutter and other cardiac rhythms

• US 6,597,943 B2
• Filed: 12/26/2000
• Issued: 07/22/2003
• Est. Priority Date: 12/26/2000
• Status: Active Grant

• Current Assignee: General Electric Company
• Original Assignee: GE Medical Systems Information Technologies Incorporated (General Electric Company)
• Inventors: Xue, Joel, Reddy, Shankara, Taha, Basel
• Primary Examiner(s): Jastrzab, Jeffrey R.
• Application Number:
  US09/748,462
• Publication Number:
  US 20020120206A1
• Time in Patent Office: 938 Days
• Field of Search: 600/515, 600/518, 600/521, 607/5, 607/14
• US Class Current: 600/515
• CPC Class Codes: A61B 5/35 by template matching
• CPC Class Codes: A61B 5/363 Detecting tachycardia or bradycardia

Abstract

A method and apparatus are provided for differentiating among atrial-flutter, atrial-fibrillation and other cardiac rhythms. The method includes the steps of estimating a spectral entropy of atrial cardiac activity from an electrocardiogram of a patient and determining that the patient has atrial fibrillation when the spectral entropy is greater than a predetermined value.

Claims

1. A method of differentiating among atrial-flutter, atrial-fibrillation and other cardiac rhythms, such method comprising the steps of:

forming a residual file by subtracting a template heartbeat from each heartbeat of an electrocardiogram of a patient;

estimating a spectral entropy of atrial cardiac activity from the residual file; and

determining that the patient has atrial fibrillation when the spectral entropy is greater than a predetermined value.

2. The method of differentiating among atrial-flutter, atrial-fibrillation and other cardiac rhythms as in claim 1 wherein the step of determining that the patient has atrial fibrillation further comprises determining that a probability density function of the spectral density has a plurality of dominant frequencies.

3. The method of differentiating among atrial-flutter, atrial-fibrillation and other cardiac rhythms as in claim 1 further comprising recording the electrocardiogram as a cardiac sample file by sampling a cardiac activity of the patient over a sampling interval.

4. The method of differentiating among atrial-flutter, atrial-fibrillation and other cardiac rhythms as in claim 3 further comprising identifying a temporal location of a plurality of R-waves within a plurality of QRS complexes of a heartbeat of the patient within the cardiac sample file over the sampling interval.

5. The method of differentiating among atrial-flutter, atrial-fibrillation and other cardiac rhythms as in claim 4 further comprising determining an average temporal distance between successive R-waves identified within the QRS complex of the heartbeat of the patient over the sampling interval.

6. A method of differentiating among atrial-flutter, atrial-fibrillation and other cardiac rhythms, such method comprising the steps of:

recording an electrocardiogram of a patient as a cardiac sample file by sampling a cardiac activity of the patient over a sampling interval;

identifying a temporal location of a plurality of R-waves within a plurality of QRS complexes of a heartbeat of the patient within the cardiac sample file over the sampling interval;

determining an average temporal distance between successive R-waves identified within the QRS complex of the heartbeat of the patient over the sampling interval;

forming a template of the QRS complex and T-wave by averaging respective sample values ahead of and behind the identified R-wave

estimating a spectral entropy of atrial cardiac activity from the electrocardiogram of a patient; and

determining that the patient has atrial fibrillation when the spectral entropy is greater than a predetermined value.

7. The method of differentiating among atrial-flutter, atrial-fibrillation and other cardiac rhythms as in claim 6 further comprising creating a residual cardiac sample file by subtracting the template of the QRS complex from the plurality of QRS complexes within the cardiac sample file.

8. The method of differentiating among atrial-flutter, atrial-fibrillation and other cardiac rhythms as in claim 7 further comprising determining a power spectral density within the residual cardiac waveform.

9. The method of differentiating among atrial-flutter, atrial-fibrillation and other cardiac rhythms as in claim 8 further comprising determining the spectral entropy of the residual cardiac waveform from the power spectral density.

10. The method of differentiating among atrial-flutter, atrial-fibrillation and other cardiac rhythms as in claim 9 further comprising comparing the spectral entropy with a threshold value.

11. The method of differentiating among atrial-flutter, atrial-fibrillation and other cardiac rhythms as in claim 10 further comprising characterizing the patient as having atrial fibrillation when the spectral entropy exceeds the threshold and atrial flutter when it does not.

12. An apparatus for differentiating among atrial-flutter, atrial-fibrillation and other cardiac rhythms, such apparatus comprising:

means for forming a residual file by subtracting a template heartbeat from each heartbeat of an electrocardiogram of a patient;

means for estimating a spectral entropy of atrial cardiac activity from the residual file; and

means for determining that the patient has atrial fibrillation when the spectral entropy is greater than a predetermined value.

13. The apparatus for differentiating among atrial-flutter, atrial-fibrillation and other cardiac rhythms as in claim 12 wherein the means for determining that the patient has atrial fibrillation further comprises means for determining that a probability density function of the spectral density has a plurality of dominant frequencies.

14. The apparatus for differentiating among atrial-flutter, atrial-fibrillation and other cardiac rhythms as in claim 13 further comprising means for identifying a temporal location of a plurality of R-waves within a plurality of QRS complexes of a heartbeat of the patient within the cardiac sample file over the sampling interval.

15. The apparatus for differentiating among atrial-flutter, atrial-fibrillation and other cardiac rhythms as in claim 14 further comprising means for determining an average temporal distance between successive R-waves identified within the QRS complex of the heartbeat of the patient over the sampling interval.

22. The apparatus for differentiating among atrial-flutter, atrial-fibrillation and other cardiac rhythms as in claim 12 further comprising means for recording the electrocardiogram as a cardiac sample file by sampling a cardiac activity of the patient over a sampling interval.

16. An apparatus for differentiating among atrial-flutter, atrial-fibrillation and other cardiac rhythms, such apparatus comprising:

means for recording an electrocardiogram of a patient as a cardiac sample file by sampling a cardiac activity of the patient over a sampling interval;

means for identifying a temporal location of a plurality of R-waves within a plurality of QRS complexes of a heartbeat of the patient within the cardiac sample file over the sampling interval;

means for determining an average temporal distance between successive R-waves identified within the QRS complex of the heartbeat of the patient over the sampling interval;

means for forming a template of the QRS complex and T-wave by averaging respective sample values ahead of and behind the identified R-wave;

means for estimating a spectral entropy of atrial cardiac activity from the electrocardiogram of the patient; and

means for determining that the patient has atrial fibrillation when the spectral entropy is greater than a predetermined value.

17. The apparatus for differentiating among atrial-flutter, atrial-fibrillation and other cardiac rhythms as in claim 16 further comprising means for creating a residual cardiac sample file by subtracting the template of the QRS complex from the plurality of QRS complexes within the cardiac sample file.

18. The apparatus for differentiating among atrial-flutter, atrial-fibrillation and other cardiac rhythms as in claim 17 further comprising means for determining a power spectral density within the residual cardiac waveform.

19. The apparatus for differentiating among atrial-flutter, atrial-fibrillation and other cardiac rhythms as in claim 18 further comprising means for determining the spectral entropy of the residual cardiac waveform from the power spectral density.

20. The apparatus for differentiating among atrial-flutter, atrial-fibrillation and other cardiac rhythms as in claim 19 further comprising means for comparing the spectral entropy with a threshold value.

21. The apparatus for differentiating among atrial-flutter, atrial-fibrillation and other cardiac rhythms as in claim 20 further comprising means for characterizing the patient as having atrial fibrillation when the spectral entropy exceeds the threshold and atrial flutter when it does not.

23. An apparatus for differentiating among atrial-flutter, atrial-fibrillation and other cardiac rhythms, such apparatus comprising:

a residual file formed by subtracting a template heartbeat from each heartbeat of an electrocardiogram of a patient;

an entropy processor adapted to estimate a spectral entropy of atrial cardiac activity from the residual file; and

an evaluation processor adapted to determine that the patient has atrial fibrillation when the spectral entropy is greater than a predetermined value.

24. The apparatus for differentiating among atrial-flutter, atrial-fibrillation and other cardiac rhythms as in claim 23 wherein the evaluation processor further comprises a peak detector adapted to determine that a probability density function of the spectral density has a plurality of dominant frequencies.

25. The apparatus for differentiating among atrial-flutter, atrial-fibrillation and other cardiac rhythms as in claim 23 further comprising a sampling processor adapted to create the electrocardiogram by sampling a cardiac activity of the patient over a sampling interval and store the samples within a cardiac sample file.

26. The apparatus for differentiating among atrial-flutter, atrial-fibrillation and other cardiac rhythms as in claim 25 further comprising a waveform processor adapted to identify a temporal location of a plurality of R-waves within a plurality of QRS complexes of a heartbeat of the patient within the cardiac sample file over the sampling interval.

27. The apparatus for differentiating among atrial-flutter, atrial-fibrillation and other cardiac rhythms as in claim 26 further comprising a timing processor adapted to determine an average temporal distance between successive R-waves identified within the QRS complex of the heartbeat of the patient over the sampling interval.

28. An apparatus for differentiating among atrial-flutter, atrial-fibrillation and other cardiac rhythms, such apparatus comprising:

a sampling processor adapted to create the electrocardiogram by sampling a cardiac activity of a patient over a sampling interval and store the samples within a cardiac sample file;

a waveform processor adapted to identify a temporal location of a plurality of R-waves within a plurality of QRS complexes of a heartbeat of the patient within the cardiac sample file over the sampling interval;

a timing processor adapted to determine an average temporal distance between successive R-waves identified within the QRS complex of the heartbeat of the patient over the sampling interval;

a template processor adapted to form a template of the QRS complex and T-wave by averaging respective sample values ahead of and behind the identified R-wave;

an entropy processor adapted to estimate a spectral entropy of atrial cardiac activity from an electrocardiogram of a patient; and

an evaluation processor adapted to determine that the patient has atrial fibrillation when the spectral entropy is greater than a predetermined value.

29. The apparatus for differentiating among atrial-flutter, atrial-fibrillation and other cardiac rhythms as in claim 28 further comprising a comparison processor adapted to create a residual cardiac sample file by subtracting the template of the QRS complex from the plurality of QRS complexes within the cardiac sample file.

30. The apparatus for differentiating among atrial-flutter, atrial-fibrillation and other cardiac rhythms as in claim 29 further comprising a Fourier processor adapted to determine a power spectral density within the residual cardiac waveform.

31. The apparatus for differentiating among atrial-flutter, atrial-fibrillation and other cardiac rhythms as in claim 30 further comprising a summation processor adapted to determine the spectral entropy of the residual cardiac waveform from the power spectral density.

32. The apparatus for differentiating among atrial-flutter, atrial-fibrillation and other cardiac rhythms as in claim 31 further comprising a threshold processor adapted to compare the spectral entropy with a threshold value.

33. A method of differentiating among atrial-flutter, atrial-fibrillation and other cardiac rhythms, such method comprising the steps of:

forming a residual file by subtracting a template heartbeat from each heartbeat of an electrocardiogram of a patient;

estimating a power spectral density of atrial electrical activity present within the residual file;

calculating a spectral entropy from the estimated power spectral density;

comparing the calculated spectral entropy with a threshold value; and

determining that the patient has atrial-fibrillation when the compared spectral entropy exceeds the threshold and atrial flutter when the compared spectral entropy does not exceed the threshold.