Electronic card for transdermal drug delivery and analyte extraction

• US 6,597,946 B2
• Filed: 05/17/2001
• Issued: 07/22/2003
• Est. Priority Date: 11/09/1998
• Status: Expired due to Term

• Current Assignee: Syneron Medical Limited (Syneron Incorporated)
• Original Assignee: TransPharma Ltd.
• Inventors: Gross, Yossi, Avrahami, Zohar, Sohn, Zeʼev
• Primary Examiner(s): KENNEDY, SHARON E
• Application Number:
  US09/859,646
• Publication Number:
  US 20020038101A1
• Time in Patent Office: 796 Days
• Field of Search: 604/19-20, 607/2, 607/3, 607/152, 600/391, 600/372
• US Class Current: 604/20
• CPC Class Codes: A61N 1/0412 Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
• CPC Class Codes: A61N 1/0428 Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
• CPC Class Codes: A61N 1/30 Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
• CPC Class Codes: A61N 1/325 for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body electrodes for external use A61N1/0428

Abstract

Devices for facilitating transdermal passage of materials are provided. In a preferred embodiment, a device for delivering a substance to skin of a subject is provided. A substance storage unit is adapted to store the substance. An analysis unit is adapted to receive a portion of a body fluid of the subject, to analyze the portion, and to generate a signal responsive to the analysis of the portion. One or more electrodes are adapted to be placed at respective sites on the skin. A substance delivery unit is adapted to receive the signal, and, responsive thereto, to drive at least some of the one or more electrodes to apply to respective ones of the sites on the skin a current capable of ablating stratum corneum epidermidis of the skin, so as to facilitate delivery of the substance from the storage unit through the skin at the respective ones of the sites.

Claims

1. A device for facilitating transdermal passage of a substance through skin of a subject, comprising:

one or more electrodes, which are adapted to be placed at respective sites on the skin; and

a control unit, which is adapted;

to drive at least some of the one or more electrodes to apply to respective ones of the sites on the skin a current capable of ablating stratum corneum epidermidis of the skin, so as to facilitate transdermal passage of the substance through the skin,

to designate at a first time a first number of the one or more electrodes to drive to apply the current, responsive to a desired rate of passage of the substance during a first time period, and

to designate at a second time a second number of the one or more electrodes to drive to apply the current, responsive to a desired rate of passage of the substance during a second time period, the second number being different from the first number.

2. A device according to claim 1, wherein the control unit is adapted to drive the current as an alternating current (AC).

3. A device according to claim 2, wherein the control unit is adapted to configure a frequency of the current to be between about 1 kHz and about 300 kHz.

4. A device according to claim 1, wherein the control unit is adapted to drive the current that is capable of causing ablation during a first time period, so as to facilitate passage of the substance through an ablated area of the stratum corneum during a second time period, subsequent to the first time period.