Iontophoresis device

• US 6,597,947 B1
• Filed: 10/12/2001
• Issued: 07/22/2003
• Est. Priority Date: 04/13/1999
• Status: Expired due to Term

• Current Assignee: Hisamitsu Pharmaceutical Company Incorporated
• Original Assignee: Hisamitsu Pharmaceutical Company Incorporated
• Inventors: Higo, Naruhito, Adachi, Hirotoshi, Maeda, Hiroyuki, Inoue, Kazutaka
• Primary Examiner(s): Hayes, Michael J.
• Assistant Examiner(s): Thompson, Kathryn L.
• Application Number:
  US09/958,599
• Time in Patent Office: 648 Days
• Field of Search: 604/20, 604/890.1
• US Class Current: 604/20
• CPC Class Codes: A61N 1/30 Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis

Abstract

The present invention provides an iontophoresis device allowing effective and continuous absorption for a long period. The iontophoresis device comprises the first electrode structure (100a) and the second electrode structure (110a) each having a hydrophilic conductive layer (102a, 112a) containing active ingredient and an electrode member (101a, 111a), and a power supply (120a) having polarity inverting means for switching over a current direction between the two electrode structures, wherein at least one of the first and the second electrode structures contains chloride ions and before administration, a chloride-ion content (P mg) is within a range satisfying the following equation:

1.0×(I×T×0.022)≦P

wherein T represents a polarity inverting time (min) until polarity is inverted after energization in a certain direction and I represents an average current (mA).

Claims

1. An iontophoresis device comprising:

first and second electrode structures each having a hydrophilic conductive layer containing at least one active ingredient and an electrode member made of an active electrode material; and

a power supply having polarity inverting means which is electrically connected between the electrode members in the first and the second electrode structures for switching over a current direction between the two electrode structures, wherein at least one of the first and the second electrode structures contains chloride ions and before administration, a chloride-ion content (P mg) is within a range satisfying the following equation;

2. The iontophoresis device according to claim 1, wherein the electrode member is formed by printing a conductive ink containing at least silver and silver chloride.

3. The iontophoresis device according to claim 2, wherein a composition ratio or mixing ratio of silver and silver chloride in the electrode member is 1:

9 to 9;

1.

4. The iontophoresis device according to claim 2, wherein the electrode member further contains a halogenated compound.

5. The iontophoresis device according to claim 1, wherein the chloride ions are supplied from a resin or polymer containing at least quaternary ammonium chloride.

6. The iontophoresis device according to claim 5, wherein the resin is selected from the group consisting of ethyl acrylate-methyl methacrylate-methyl methacrylate trimethylammonium chloride copolymers and cholestyramine.

7. The iontophoresis device according to claim 1, wherein the electrode structure contains an organic amine as a pH adjusting material.

8. The iontophoresis device according to claim 7, wherein the pH adjusting material is at least one of meglumine, tromethamol, triethanolamine and aminoacrylate.

9. The iontophoresis device according to claim 1, wherein the active ingredient is neutral or cationic and polarity inversion is periodically repeated by the power supply.

10. The iontophoresis device according to claim 1 wherein the power supply includes timer means for controlling a polarity inverting time.

11. The iontophoresis device according to claim 1, wherein chloride ions are contained in the hydrophilic conductive layer or an additional hydrophilic conductive layer placed between the electrode member and the hydrophilic conductive layer.

12. The iontophoresis device according to claim 1, wherein first and second electrode structures have the same composition containing a given amount of chloride ions at least one active ingredient.

13. The iontophoresis device according to claim 1, wherein the chloride ions are supplied from hydrochloric acid.

14. The iontophoresis device according to claim 1, wherein the chloride ions are supplied from at least one active ingredient hydrochloride.

15. The iontophoresis device according to claim 1, wherein the power supply includes means for shorting a circuit in polarity inversion and/or means for providing a non-energization time for a given period.

16. The iontophoresis device according to claim 1, wherein the polarity inversion by the power supply is conducted at least once and a time for one polarity inversion is 1 min to 2 hours.

17. The iontophoresis device according to claim 1, wherein the current applied by the power supply is at least one of direct current, pulse direct current and pulse depolarized direct current.

18. The iontophoresis device according to claim 1, wherein the electrode structures include an insulating support having a pit, which accommodates the electrode member and the hydrophilic conductive layer therein and whose surface is covered by a semipermeable membrane, a selective permeation membrane, a control membrane or a hydrophilic porous membrane.

19. An iontophoresis device comprising:

first and second electrode structures each having a hydrophilic conductive layer containing at least one active ingredient and an electrode member made of an active electrode material; and

a power supply having polarity inverting means which is electrically connected between the electrode members in the first and the second electrode structures for switching over a current direction between the two electrode structures, wherein at least one of the first and the second electrode structures contains chloride ions and before administration, a chloride-ion content (P mg) is within a range satisfying the following equation;

20. The iontophoresis device according to claim 19, wherein the active ingredient is anionic and polarity inversion is periodically repeated by the power supply.