Heating of magnetic material by hysteresis effects

• US 6,599,234 B1
• Filed: 12/20/2001
• Issued: 07/29/2003
• Est. Priority Date: 03/03/1999
• Status: Expired due to Term

• Current Assignee: Sirtex Medical Limited
• Original Assignee: Sirtex Medical Limited
• Inventors: Cammarano, Raffaele, Jones, Stephen Keith, Gray, Bruce Nathaniel
• Primary Examiner(s): Gilbert, Samuel G.
• Application Number:
  US09/914,714
• Time in Patent Office: 586 Days
• Field of Search: 600/9-15, 600/1-8, 607/100-104, 424/322, 423/633
• US Class Current: 600/12
• CPC Class Codes: A61K 33/24 Heavy metals; Compounds thereof
• CPC Class Codes: A61K 41/0052 Thermotherapy; Hyperthermia; Magnetic induction; Induction heating therapy
• CPC Class Codes: A61K 51/12 characterised by a special physical form, e.g. emulsion, microcapsules, liposomes , characterized by a special physical form, e.g. emulsions, dispersions, microcapsules liposomes A61K51/1234
• CPC Class Codes: A61N 1/406 using implantable thermoseeds or injected particles for localized hyperthermia preparations of seeds and particles A61K41/0052
• CPC Class Codes: A61P 35/00 Antineoplastic agents

Abstract

A magnetic material having a magnetic heating efficiency of at least 4.5×10⁻⁸ J.m/A.g in a cyclic magnetic field where the product of the amplitude and frequency of the applied field is less than or equal to 5×10⁸ A/m.s, and the frequency of the applied filed is at least 20 kHz. The ideal magnetic material is characterized by a perfectly rectangular hysteresis loop, i.e. loop squareness of 1, with coercivity of 25 kA/m or less and high saturation magnetization. Preferably the magnetic material has a predominately cubic magnetic crystalline anisotropy. Preferably the magnetic material is a substituted magnetite (Fe₃O₄) or γ-ferric oxide (γFe₂O₃) crystalline lattice in which some of the iron atoms in that crystalline lattice have been substituted for one or more alternate metals atoms. Desirably, the metal atom is a member of the group: cobalt, zinc, nickel, manganese, magnesium, copper, chromium, gallium, cadmium.

Claims

1. A magnetic material having a magnetic heating efficiency of at least 4.5×

10<sup>−

8</sup> J.m/A.g in a cyclic magnetic field where the product of the amplitude and frequency of the applied field is less than or equal to 5×

10⁸ A/m.s, and the frequency of the applied field is at least 20 kHz and wherein (i) the magnetic material is a substituted magnetite (Fe₃O₄) or gamma ferric oxide (γ

-Fe₂O₃) crystalline lattice in which some of the iron atoms in that crystalline lattice have been substituted for one or more alternate metal atoms and (ii) the magnetic material has a predominantly cubic magnetocrystalline anisotropy.

2. A magnetic material according to claim 1 wherein the magnetic material is provided in particulate form, with particles possessing equant morphology.

3. A magnetic material according to any one of claim 2 wherein the particles are of a size between 20 nm and 1 μ

m.

4. A magnetic material according to claim 2 characterised by loop squareness of between 0.5 and 1 with coercivity of 25 kA/m or less and high saturation magnetism.

5. A magnetic material according to claim 1 wherein the magnetic material has a coercivity of less that 314 Oe.

6. A magnetic material according to claim 5 wherein the coercivity is less than 200 Oe.

7. A magnetic material according to claim 1 wherein the substituting metal atoms are selected from a group consisting of cobalt, zinc, nickel, manganese, magnesium, copper, chromium, gallium, and cadmium.

8. A magnetic material according to claim 7 wherein the substituting metal atoms may either be selected entirely from the same atomic species or a plurality of different metal atoms can be incorporated into the crystalline lattice.

9. A magnetic material according to claim 7 wherein the substituting metal atoms are dispersed in a substantially even manner throughout the crystalline lattice.

10. A magnetic material according to claim 7 wherein the substituting metal atom is cobalt.

11. A magnetic material according to claim 10 wherein the degree of substitution with cobalt atoms is less than about 4% of the iron atoms in the crystalline lattice.

12. A magnetic material according to claim 11 wherein the degree of substitution with cobalt atoms is in the range of 0.2 and 3.5% of the iron atoms in the crystalline lattice.

13. A magnetic material according to claim 1 wherein the magnetic heating efficiency of that material is such as to enable production of sufficient heat to raise the temperature of the surrounding matter to 42°

C.

14. A magnetic material according to claim 13 wherein the magnetic material is capable of producing at least 22.5 watts per gram of material when exposed to a cyclic magnetic field.

15. A magnetic material according to claim 13 wherein the magnetic material is delivered in the form of microcapsules to the site of cancer via intra-arterial infusion.

16. A microcapsule comprising a magnetic material according to claim 1 wherein the magnetic material is bound in a matrix material.

17. A microcapsule according to claim 16 wherein the magnetic material is bound in a matrix material which does not adversely affect the hysteresis or eddy current heating properties of the magnetic particles.

18. A microcapsule according to claim 16 wherein the matrix material is selected from a group comprising proteins, polymeric resins such as styrene-divinyl benzene, biopol, albumin and chitosan.

19. A microcapsule according to claim 16 wherein the microcapsules are adapted to bind or absorb or contain a cytotoxic material.

20. A microcapsule according to claim 19 wherein the cytotoxic material is released upon heating of the microcapsule.

21. A microcapsule according to claim 16 wherein the microcapsule is composed of a porous, heat sensitive material which is non-toxic and inert to or compatible with animal tissue and which has embedded within it suitable magnetic material.

22. A microcapsule according to claim 16 wherein the pores within the porous material are filled with a cytotoxic material.

23. A composition comprising (i) a magnetic material having a magnetic heating efficiency of at least 4.5×

10<sup>−

8</sup> J.m/A.g in a cyclic magnetic field where the product of the amplitude and frequency of the applied field is less than or equal to 5×

10⁸ A/m.s, and the frequency of the applied filed is at least 20 kHz and wherein (i) the magnetic material is a substitute magnetite (Fe₃O₄) or gamma ferric oxide (γ

Fe₂O₃) crystalline lattice in which some of the iron atoms in that crystalline lattice have been substituted for one or more alternate metals atoms and (ii) the magnetic material has a predominately cubic magnetocrystalline anisotropy, or a microcapsule according to claim 16 and (ii) at least a microcapsule suspension selected from the group consisting of radioactive microcapsules or chemotherapeutic microcapsules.

24. A composition according to claim 23 wherein the radioactive microcapsules at least contain Yttrium-90 as the radiation source.

25. A composition comprising a magnetic material according to claim 1 in a liquid medium suspension.

26. A composition according to claim 23 wherein the liquid medium is lipiodol.

27. A method for site specific treatment of diseased tissue in a patient, which comprises the steps of:

(i) delivering the magnetic material of anyone of claims 1 to 14 or the microcapsule according to anyone of claims 16 to 20 or the composition according to anyone of claims 23 to 26 to the diseased tissue in a patient; and

(ii) exposing the magnetic material in the patient to a cyclic magnetic field with a frequency of about 20 kHz and a field strength selected such that the product of field strength, frequency and the radius of the exposed region is less than about 7.5×

10⁷ A/s to generate hysteresis heat in the diseased tissue wherein the magnetic material is a substituted magnetite (Fe₃O₄) or gamma ferric oxide (γ

-Fe₂O₃) crystalline lattice in which some of the iron atoms in that crystalline lattice have been substituted for one or more alternate metal atoms and (ii) the magnetic material has a predominantly cubic magnetocrystalline anisotropy.

28. A method for site specific treatment of diseased tissue in a patient according to claim 27 wherein the magnetic material is provided in particulate form, with particles possessing equant morphology.

29. A method for site specific treatment of diseased tissue in a patient according to claim 27 wherein step (ii) is carried out for sufficient time to generate enough heat from the administered magnetic material to raise the diseased tissue temperature above about 42°

C.

30. A method for site specific treatment of diseased tissue in a patient according to claim 27 wherein step (ii) is repeated until the diseased tissue has been destroyed or treated sufficiently to ameliorate the disease.

31. A method for specific treatment of diseased tissue in a patient according to claim 27 wherein the cyclic magnetic field is a linear alternating magnetic field of strength H and frequency f.

32. A method for site specific treatment of diseased tissue according to claim 31 wherein the radiation source may be microcapsules which contain a radioactive source such a Yttrium-90 or delivered from an external radiation source.

33. A method for specific treatment of diseased tissue in a patient according to claim 27 wherein the cyclic magnetic field is a rotating magnetic field of strength H and frequency f.

34. A method for site specific treatment of diseased tissue in a patient according to claim 27 wherein an ionizing radiation source is applied to the locus of the diseased tissue in junction with a magnetic field.

35. An antipilferage device comprising a magnetic material having a magnetic heating efficiency of at least 4.5×

10<sup>−

8</sup> J.m/A.g in a cyclic magnetic field where the product of the amplitude and frequency of the applied field is less than or equal to 5×

10⁸ a/m.s, and the frequency of the applied filed is at least 20 kHz and wherein (i) the magnetic material is a substitute magnetite (Fe₃O₄) or gamma ferric oxide (γ

Fe₂O₃) crystalline lattice in which some of the iron atoms in that crystalline lattice have been substituted for one or more alternate metals atoms and (ii) the magnetic material has a predominately cubic magnetocrystalline anisotropy.