Concentration measuring apparatus, test strip for the concentration measuring apparatus, biosensor system and method for forming terminal on the test strip
First Claim
1. A concentration measuring apparatus and a test strip which is applied thereto, the test strip including on a base material a reaction reagent for reacting with a liquid test sample, a positive terminal, and a negative terminal, the terminals electrically detecting a concentration of a specific component in the liquid test sample based on the reaction of the reaction reagent, the concentration measuring apparatus comprising a positive electrode and a negative electrode to be electrically connected respectively to the positive terminal and the negative terminal of the test strip, thereby measuring the concentration of the specific component in the liquid test sample via the positive electrode and the negative electrode,the concentration measuring apparatus further comprising a reagent identifying electrode for identifying a type of the reaction reagent formed on the test strip which measures the concentration of a sample applied to the concentration measuring apparatus, with the reagent identifying electrode being provided separately from the positive electrode and negative electrode;
- a first identification device for feeding information corresponding to the test strip based on the reagent identifying electrode being connected with the positive electrode only when the test strip is applied to the concentration measuring apparatus, and a second identification device for identifying the test strip based on the information fed from the first identification device.
4 Assignments
0 Petitions
Accused Products
Abstract
The present invention is to provide a concentration measuring apparatus, a test strip for the concentration measuring apparatus, a biosensor system and a method for forming terminals of the test strip, whereby a component to be measured can be measured by the test strip fit to the target component to be measured. A type judgement electrode is provided separately from a positive electrode and a negative electrode in a measuring apparatus so as to judge the type of a set test strip with the measuring apparatus. Thus only when a test strip matching the measuring apparatus is set, the type judgement electrode is electrically connected to a terminal of the set test strip, enabling the measuring apparatus to measure a component to be measured in a liquid test sample. A measuring apparatus detects a calibration curve information selection change for selecting a calibration curve information corresponding to a production lot of the set test strip thereby to compensate for an error in a measured concentration value of the component.
-
Citations
52 Claims
-
1. A concentration measuring apparatus and a test strip which is applied thereto, the test strip including on a base material a reaction reagent for reacting with a liquid test sample, a positive terminal, and a negative terminal, the terminals electrically detecting a concentration of a specific component in the liquid test sample based on the reaction of the reaction reagent, the concentration measuring apparatus comprising a positive electrode and a negative electrode to be electrically connected respectively to the positive terminal and the negative terminal of the test strip, thereby measuring the concentration of the specific component in the liquid test sample via the positive electrode and the negative electrode,
the concentration measuring apparatus further comprising a reagent identifying electrode for identifying a type of the reaction reagent formed on the test strip which measures the concentration of a sample applied to the concentration measuring apparatus, with the reagent identifying electrode being provided separately from the positive electrode and negative electrode; -
a first identification device for feeding information corresponding to the test strip based on the reagent identifying electrode being connected with the positive electrode only when the test strip is applied to the concentration measuring apparatus, and a second identification device for identifying the test strip based on the information fed from the first identification device. - View Dependent Claims (2, 3, 4)
-
-
5. A concentration measuring apparatus and a test strip which is applied thereto, the test strip including on a base material a reaction reagent for reacting with a liquid test sample, a positive terminal, and a negative terminal, the terminals electrically detecting a concentration of a specific component in the liquid test sample based on the reaction of the reaction reagent, the concentration measuring apparatus comprising a positive electrode and a negative electrode to be electrically connected respectively to the positive terminal and the negative terminal of the test strip, thereby measuring the concentration of the specific component in the liquid test sample via the positive electrode and the negative electrode,
the concentration measuring apparatus further comprising a reagent identifying electrode for identifying a type of the reaction reagent formed on the test strip which measures the concentration of a sample applied to the concentration measuring apparatus, with the reagent identifying electrode being provided separately from the positive electrode and negative electrode; switches for connecting and disconnecting the reagent identifying electrode and positive electrode to an identification device, and for connecting and disconnecting the reagent identifying electrode and negative electrode to the identification device, the identification device for identifying that the test strip is applied to the concentration measuring apparatus on the basis of information obtained from a detecting part of the positive electrode after operating said switches. - View Dependent Claims (6, 7)
-
8. A concentration measuring apparatus and a test strip which is applied thereto, the test strip including on a base material a reaction reagent for reacting with a liquid test sample, a positive terminal, and a negative terminal, the terminals electrically detecting a concentration of a specific component in the liquid test sample based on the reaction of the reaction reagent, the concentration measuring apparatus comprising a positive electrode and a negative electrode to be electrically connected respectively to the positive terminal and the negative terminal of the test strip, thereby measuring the concentration of the specific component in the liquid test sample via the positive electrode and the negative electrode,
the concentration measuring apparatus further comprising a reagent identifying electrode for identifying a type of the reaction reagent formed on the test strip which measures the concentration of a sample applied to the concentration measuring apparatus, with the reagent identifying electrode being provided separately from the positive electrode and negative electrode; a potential judge device connected to the reagent identifying electrode which judges whether or not the reagent identifying electrode has a strip set potential corresponding to the concentration measuring apparatus generated at the reagent identifying electrode when the test strip for the liquid test sample is applied to the concentration measuring apparatus. - View Dependent Claims (9, 10, 11)
-
12. A concentration measuring apparatus and a test strip which is applied thereto, the test strip including on a base material a reaction reagent for reacting with a liquid test sample, a positive terminal, and a negative terminal, the terminals electrically detecting a concentration of a specific component in the liquid test sample based on the reaction of the reaction reagent, the concentration measuring apparatus comprising a positive electrode and a negative electrode to be electrically connected respectively to the positive terminal and the negative terminal of the test strip, thereby measuring the concentration of the specific component in the liquid test sample via the positive electrode and the negative electrode,
the concentration measuring apparatus further comprising a reagent identifying electrode for identifying a type of the reaction reagent formed on the test strip which measures the concentration of a sample applied to the concentration measuring apparatus, with the reagent identifying electrode being provided separately from the positive electrode and negative electrode; the reagent identifying electrode comprises at least two high level electrodes set at a high level potential, and a grounding electrode set at a low level potential, so that at least one of combinations of potentials at the two high level electrodes and the grounding electrode corresponds to the test strip set potential corresponding to the concentration measuring apparatus. - View Dependent Claims (13, 14)
-
15. A concentration measuring apparatus and a test strip which is applied thereto, the test strip including on a base material a reaction reagent for reacting with a liquid test sample, a positive terminal, and a negative terminal, the terminals electrically detecting a concentration of a specific component in the liquid test sample based on the reaction of the reaction reagent, the concentration measuring apparatus comprising a positive electrode and a negative electrode to be electrically connected respectively to the positive terminal and the negative terminal of the test strip, thereby measuring the concentration of the specific component in the liquid test sample via the positive electrode and the negative electrode,
the concentration measuring apparatus furthercomprising a reagent identifying electrode for identifying a type of the reaction reagent formed on the test strip which measures the concentration of a sample applied to the concentration measuring apparatus, with the reagent identifying electrode being provided separately from the positive electrode and negative electrode; -
a change judge device connected to the reagent identifying electrode which judges whether or not a potential change at the reagent identifying electrode corresponds to a test strip set change corresponding to the concentration measuring apparatus which is a change generated at the reagent identifying electrode when the test strip is applied to the concentration measuring apparatus. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51)
selects a required calibration curve information among the plurality of calibration curve information on the basis of a calibration curve information selection change included in the appropriate test strip set change at the reagent identifying electrode as well as judges a type of the test strip on the basis of the appropriate test strip set change at the reagent identifying electrode, and compensates for the error based on the selected calibration curve information; wherein the error in concentration measurement results from a reaction error of the liquid test sample caused by a production error for every production lot of the reaction reagent of the test strip applied to the concentration measuring apparatus.
-
-
20. The concentration measuring apparatus according to claim 19, wherein the change judge device stores the plurality of calibration curve information for every specific component corresponding to the type of the set test strip.
-
21. The concentration measuring apparatus according to claim 20, wherein the reagent identifying electrode includes:
-
a first electrode which exhibits the appropriate test strip set change from the high level to low level and from the low level to the high level after the test strip is started to be applied to the concentration measuring apparatus before completely applied, and the calibration curve information selection change; and
a second electrode which alternatively generates the high level potential and low level potential synchronously with the potential change at the first electrode so as to detect a timing of the potential change of the first electrode after the test strip is started to be applied to the concentration measuring apparatus before completely applied.
-
-
22. The concentration measuring apparatus according to claim 19, wherein the reagent identifying electrode includes:
-
a first electrode which exhibits the appropriate test strip set change from the high level to low level and from the low level to the high level after the test strip is started to be applied to the concentration measuring apparatus before completely applied, and the calibration curve information selection change; and
a second electrode which alternatively generates the high level potential and low level potential synchronously with the potential change at the first electrode so as to detect a timing of the potential change of the first electrode after the test strip is started to be applied to the concentration measuring apparatus before completely applied wherein the error in concentration measurement results from a reaction error of the liquid test sample caused by a production error for every production lot of the reaction reagent of the test strip applied to the concentration measuring apparatus.
-
-
23. The concentration measuring apparatus according to claim 22, further comprising a reagent detector which determines that the test strip corresponds to the concentration measuring apparatus.
-
24. The concentration measuring apparatus according to claim 22, further comprising a reagent detector which determines that the test strip having the reaction reagent which is to react to the specific component in the liquid test sample corresponds to the concentration measuring apparatus.
-
25. The concentration measuring apparatus according to claim 19, which has a reagent identifying terminal to be electrically connected to the reagent identifying electrode and letting the change judge device judge that the potential change at the reagent identifying electrode is the appropriate test strip set change for judging the type of the test strip and also letting the change judge device detect the calibration curve selection information change for selecting the required calibration curve information among the plurality of calibration curve information.
-
26. The concentration measuring according to claim 25, wherein the reagent identifying terminal has:
-
a potential change part which makes a first electrode included in the reagent identifying electrode of the concentration measuring apparatus represent the appropriate test strip set change and the calibration curve information selection change from the high level to low level and from the low level to high level after the test strip is first applied to the concentration measuring apparatus before being completely applied; and
a timing generation part which makes a second electrode included in the reagent identifying electrode of the concentration measuring apparatus alternately generate the high level potential and the low level potential synchronously with the potential change brought about to the first electrode after the test strip is first applied to the concentration measuring apparatus before being completely applied.
-
-
27. The concentration measuring apparatus according to claim 26, which includes a set completion detection terminal to be electrically connected to the positive electrode or negative electrode of the concentration measuring apparatus when the test strip is completely applied to the concentration measuring apparatus, so that the set completion detection terminal makes the concentration measuring apparatus detect the completion of the application.
-
28. The concentration measuring apparatus according to claim 26, wherein the set completion detection part and the timing generation part are electrically connected to the negative terminal of the test strip.
-
29. The method for manufacturing the concentration measuring apparatus according to claim 26, which comprises:
-
applying the reaction reagent on the base material of the test strip;
depositing a standard solution having the specific component of which a concentration is known on the applied reaction reagent;
selecting the calibration curve information compensating for an error between a detected concentration based on the reaction and the known concentration of the specific component; and
forming the reagent identifying terminal so that the calibration curve information selection change indicating at least the selected calibration curve information is generated at the reagent identifying terminal.
-
-
30. The manufacture method according to claim 29, whereby the reagent identifying terminal is formed on the base material of the test strip after the calibration curve information is selected so that the reagent identifying terminal includes an indication of the selected calibration curve information.
-
31. The manufacture method according to claim 29, whereby the reagent identifying terminal is formed in a process of preliminary forming a patternless reagent identifying terminal not showing the calibration curve information selection change on the base material of the test strip, and then forming a calibration curve information selection change pattern to the patternless reagent identifying terminal after the calibration curve information is selected so that the reagent identifying terminal includes the selected calibration curve information.
-
32. The method for manufacturing the concentration measuring apparatus according to claim 25, which comprises:
-
applying the reaction reagent on the base material of the test strip;
depositing a standard solution having the specific component of which a concentration is known on the applied reaction reagent;
selecting the calibration curve information compensating for an error between a detected concentration based on the reaction and the known concentration of the specific component; and
forming the reagent identifying terminal so that the calibration curve information selection change indicating at least the selected calibration curve information is generated at the reagent identifying terminal.
-
-
33. The manufacture method according to claim 32, whereby the reagent identifying terminal is formed on the base material of the test strip after the calibration curve information is selected so that the reagent identifying terminal includes an indication of the selected calibration curve information.
-
34. The manufacture method according to claim 32, whereby the reagent identifying terminal is formed in a process of preliminarily forming a patternless reagent identifying terminal not showing the calibration curve information selection change on the base material of the test strip, and then forming a calibration curve information selection change pattern to the patternless reagent identifying terminal after the calibration curve information is selected so that the reagent identifying terminal includes the selected calibration curve information.
-
35. The concentration measuring apparatus according to claim 19, further comprising a reagent detector which determines that the test strip corresponds to the concentration measuring apparatus.
-
36. The concentration measuring apparatus according to claim 19, further comprising a reagent detector which determines that the test strip having the reaction reagent which is to react to the specific component in the liquid test sample corresponds to the concentration measuring apparatus.
-
37. The concentration measuring apparatus according to claim 15, which comprises a reagent identifying terminal on the test strip to be electrically connected to the reagent identifying electrode and letting the change judge device judge that the potential change at the reagent identifying electrode corresponds to the test strip set change.
-
38. The concentration measuring apparatus according to claim 37, wherein the reagent identifying terminal is electrically connected to the positive terminal or negative terminal, is electrically connected to the reagent identifying electrode of the concentration measuring apparatus either when the test strip is first applied to the concentration measuring apparatus or when the test strip is completely applied to the concentration measuring apparatus, and brings about the test strip set change to the reagent identifying electrode from the high level to low level or from the low level to high level after the test strip is first applied to the concentration measuring apparatus before being completely applied.
-
39. The concentration measuring apparatus according to claim 15, wherein the change judge device stores a plurality of calibration curve information for compensating for an error in concentration measurement of the specific component in the liquid test sample,
detects a calibration curve information selection change at the reagent identifying electrode so as to select a required calibration curve information among the plurality of calibration curve information in place of judging the presence/absence of the appropriate test strip set change at the reagent identifying electrode when the concentration measuring apparatus can measure the concentration of the only one specific component and the test strip having a reaction reagent which is to react to the specific component and capable of measuring the concentration of the specific component by the concentration measuring apparatus is set to the concentration measuring apparatus, and compensates for the error based on the calibration curve information selected in accordance with the detected calibration curve information selection change; wherein the error in concentration measurement results from a reaction error of the liquid test sample caused by a production error for every production lot of the reaction reagent of the test strip applied to the concentration measuring apparatus.
-
40. The concentration measuring apparatus according to claim 39, which has a reagent identifying terminal to be electrically connected to the reagent identifying electrode and letting the change judge device detect the calibration curve information selection change for selecting the required calibration curve information among the plurality of calibration curve information on the basis of the potential at the reagent identifying electrode.
-
41. The concentration measuring apparatus according to claim 40, wherein the reagent identifying terminal comprises:
-
a potential change part which makes a first electrode included in the reagent identifying electrode of the concentration measuring apparatus represent the calibration curve information selection change from the high level potential to low level potential and from the low level potential to high level potential after the test strip is first applied to the concentration measuring apparatus before being completely applied; and
a timing generation part which makes a second electrode included in the reagent identifying electrode of the concentration measuring apparatus alternately generate the high level potential and low level potential synchronously with the potential change brought about to the first electrode after the test strip is first applied to the concentration measuring apparatus before being completely applied.
-
-
42. The concentration measuring apparatus according to claim 41, which includes a set completion detection terminal to be electrically connected to the positive electrode or the negative electrode of the concentration measuring apparatus when the test strip is completely applied to the concentration measuring apparatus, so that the completion of the applying is detected with the concentration measuring apparatus.
-
43. The concentration measuring apparatus according to claim 41, wherein the set completion detection part and the timing generation part are electrically connected to the negative terminal of the test strip.
-
44. The method for manufacturing the concentration measuring apparatus according to claim 41, which comprises:
-
applying the reaction reagent on the base material of the test strip;
depositing a standard solution having the specific component of which a concentration is known on the applied reaction reagent;
selecting the calibration curve information compensating for an error between a detected concentration based on the reaction and the known concentration of the specific component; and
forming the reagent identifying terminal so that the calibration curve information selection change indicating at least the selected calibration curve information is generated at the reagent identifying terminal.
-
-
45. The manufacture method according to claim 44, whereby the reagent identifying terminal is formed on the base material of the test strip after the calibration curve information is selected so that the reagent identifying terminal includes an indication of the selected calibration curve information terminal.
-
46. The manufacture method according to claim 44, whereby the reagent identifying terminal is formed in a process of preliminary forming a patternless reagent identifying terminal not showing the calibration curve information selection change on the base material of the test strip, and then forming a calibration curve information selection change pattern to the patternless reagent identifying terminal after the calibration curve information is selected so that the reagent identifying terminal includes the selected calibration curve information.
-
47. The method for manufacturing the concentration measuring apparatus according to claim 40, comprises:
-
applying the reaction reagent on the base material of the test strip;
depositing a standard solution having the specific component of which a concentration is known on the applied reaction reagent;
selecting the calibration curve information compensating for an error between a detected concentration based on the reaction and the known concentration of the specific component; and
forming the reagent identifying terminal so that the calibration curve information selection change indicating at least the selected calibration curve information is generated at the reagent identifying terminal.
-
-
48. The manufacture method according to claim 47, whereby the reagent identifying terminal is formed on the base material of the test strip after the calibration curve information is selected so that the reagent identifying terminal includes an indication of the selected calibration curve information.
-
49. The manufacture method according to claim 47, whereby the reagent identifying terminal is formed in a process of preliminary forming a patternless reagent identifying terminal not showing the calibration curve information selection change on the base material of the test strip, and then forming a calibration curve information selection pattern to the patternless reagent identifying terminal after the calibration curve information is selected so that the reagent identifying terminal includes an indication of the selected calibration curve information.
-
50. The concentration measuring apparatus according to claim 15, further comprising a reagent detector which determines that the test strip corresponds to the concentration measuring apparatus.
-
51. The concentration measuring apparatus according to claim 15, further comprising a reagent detector which determines that the test strip having the reaction reagent which is to react to the specific component in the liquid test sample corresponds to the concentration measuring apparatus.
-
52. A biosensor system comprising:
-
a first concentration measuring apparatus comprising the concentration measuring apparatus to which a test strip is applied, the test strip including on a base material a reaction reagent reacting with a liquid test sample, a positive terminal, and a negative terminal, the terminals electrically detecting a concentration of a specific component in the liquid test sample based on the reaction of the reaction reagent, the concentration measuring apparatus comprising a positive electrode and a negative electrode to be electrically connected respectively to the positive terminal and the negative terminal of the test strip, thereby measuring the concentration of the specific component in the liquid test sample via the positive electrode and the negative electrode, the concentration measuring apparatus further comprising a reagent identifying electrode for identifying a type of the reaction reagent formed on the test strip which measures the concentration of a sample applied to the concentration measuring apparatus, with the reagent identifying electrode being provided separately from the positive electrode and negative electrode, and which further comprises a first identification device for feeding information corresponding to the test strip based on the reagent identifying electrode being connected with the positive electrode only when the test strip is applied to the concentration measuring apparatus, and a second identification device for identifying the test strip based on the information fed from the first identification device and wherein the positive electrode, the reagent identifying electrode, and the negative electrode are arranged in this order in a transverse direction of a test strip;
a first test strip, including on a base material a reaction reagent for reacting with a liquid test sample, a positive terminal, and a negative terminal, the terminals electrically detecting a concentration of a specific component in the liquid test sample based on the reaction of the reaction reagent, a reagent identifying terminal which is electrically connected to the reagent identifying electrode and positive electrode, applied to the first concentration measuring apparatus, which includes first terminals to be electrically connected to the positive electrode and the reagent identifying electrode, and a second terminal to be electrically connected to the negative electrode;
a second concentration measuring apparatus comprising the concentration measuring apparatus as used for the first concentration measuring apparatus wherein the positive electrode, the negative electrode, and the reagent identifying electrode are arranged in this order in the transverse direction; and
a second test strip, including on a base material a reaction reagent for reacting with a liquid test sample, a positive terminal, and a negative terminal, the terminals electrically detecting a concentration of a specific component in the liquid test sample based on the reaction of the reaction reagent, a reagent identifying terminal which is electrically connected to the reagent identifying electrode and positive electrode, applied to the second concentration measuring apparatus which includes a first terminal to be electrically connected to the positive electrode and reagent identifying electrode and a second terminal to be electrically connected to the negative electrode, said biosensor system so constituted that a concentration of the specific component cannot be measured if the first test strip is applied to the second concentration measuring apparatus, and if the second test strip is applied to the first concentration measuring apparatus.
-
Specification