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Multifunctionalized solid support resins for synthesis of combinatorial libraries and method for using the same

  • US 6,600,016 B1
  • Filed: 08/24/1999
  • Issued: 07/29/2003
  • Est. Priority Date: 08/24/1999
  • Status: Expired due to Fees
First Claim
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1. A multifunctionalized solid support for the solid support synthesis of at least two different compounds, said solid support having the structure:

  • embedded imagewherein P is a resin backbone, T is a diamino acid moiety template having at least three attachment points, X is a covalent bonding entity for attachment of T to P and L1 and L2 are independently different benzyl linker moieties having the formula;

    embedded imagewherein Z is selected from the group consisting of a covalent bond, O, —

    C(O)—

    , C1-6 alkylene, C5-10 aryl, carbonylC1-6alkylene, carbonylC1-6alkyleneoxy, carbonyl C5-10 aryl and carbonyl C5-10 heteroaryl, said alkylene, aryl and heteroaryl groups being substituted with H or C1-3 alkyl;

    R1 and R2 are independently selected from the group consisting of H, nitro, halo and C1-6alkoxy;

    R3 and R4 are independently selected from the group consisting of H, C1-6 alkyl, C5-10 aryl and C5-10 heteroaryl, said alkyl, aryl and heteroaryl groups being substituted with H, C1-3 alkyl or C1-3 alkoxy; and

    W is selected from the group consisting of OH, NH2 and NHpg where pg is a protecting group.

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