Method for monitoring heart failure via respiratory patterns

• US 6,600,949 B1
• Filed: 05/05/2000
• Issued: 07/29/2003
• Est. Priority Date: 11/10/1999
• Status: Expired due to Term

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories)
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories)
• Inventors: Turcott, Robert
• Primary Examiner(s): LAYNO, CARL HERNANDZ
• Application Number:
  US09/566,193
• Time in Patent Office: 1,180 Days
• Field of Search: 600/481, 600/508, 600/513, 600/527, 600/518, 600/534, 607/20, 607/22
• US Class Current: 600/518
• CPC Class Codes: A61B 2562/0204 Acoustic sensors
• CPC Class Codes: A61B 5/0002 Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network A61B5/07 takes precedence; transmission systems for measured values G08C; transmission H04B; transmission of digital information H04L; wireless communication networks H04W
• CPC Class Codes: A61B 5/02 Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
• CPC Class Codes: A61B 5/0205 Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
• CPC Class Codes: A61B 5/024 Detecting, measuring or recording pulse rate or heart rate A61B5/0205, A61B5/021 take precedence
• CPC Class Codes: A61B 5/0816 Measuring devices for examining respiratory frequency measuring frequency of electric signals G01R23/00
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/282 Holders for multiple electrodes for introduction into the body A61B5/287
• CPC Class Codes: A61B 5/6816 Ear lobe
• CPC Class Codes: A61B 5/6817 Ear canal
• CPC Class Codes: A61B 7/04 Electric stethoscopes microphones, acoustic transducers therefor H04R

Abstract

A method for monitoring the condition of a heart failure patient using respiration patterns is provided. An implantable or other ambulatory monitor senses the patient'"'"'s respiratory patterns to identify the presence of periodic breathing or Cheyne-Stokes respiration. In a first embodiment, mechanical changes of the thorax due to breathing are detected and this data is used to recognize hyperventilation and apnea or hypoventilation. In a second embodiment of the invention, Cheyne-Stokes respiration is recognized by detecting changes in blood or tissue pH or CO₂ concentration and partial pressure. In another embodiment of the invention, changes in pulse amplitude associated with Cheyne-Stokes respiration are detected. Alternating loss and return of respiration-induced amplitude modulation or pulse-interval variation may also be used to identify the presence of Cheyne-Stokes respiration. In yet another embodiment of the invention, modulation of the average heart rate over time is monitored and its absence is used as an indicator of Cheyne-Stokes respiration. This information may be used to warn the patient or healthcare provider of changes in the patient'"'"'s condition warranting attention.

Claims

1. A method for monitoring the progression of the disease state of a heart failure patient comprising the steps of:

(a) sensing mechanical changes of the patient'"'"'s thorax to detect the patient'"'"'s respiratory cycles; and

(b) analyzing said respiratory cycles to determine if said patient is experiencing periodic breathing and to provide an indication of the progression of the disease state of said patient.

2. The method of claim 1 wherein said step of sensing mechanical changes comprises generating an ultrasound signal and detecting reflections of said signal from within said patient'"'"'s thorax.

3. The method of claim 1 wherein said step of sensing mechanical changes comprises sensing pressure changes within said patient'"'"'s thorax.

4. The method of claim 3 wherein said step of sensing pressure changes comprises sensing signals from an extravascular extracardiac pressure transducer.

5. The method of claim 3 wherein said step of sensing pressure changes comprises sensing signals from an intravascular pressure transducer.

6. The method of claim 3 wherein said step of sensing pressure changes comprises sensing signals from an intracardiac pressure transducer.

7. A method for monitoring the progression of the disease state of a heart failure patient comprising the steps of:

(a) sensing a pH level of the patient'"'"'s blood or tissue;

(b) storing measures of the pH over time; and

(c) analyzing variations in said pH level to determine if said patient is experiencing periodic breathing and to provide an indication of the progression of the disease state of said patient.

8. A method for monitoring the progression of the disease state of a heart failure patient comprising the steps of:

(a) sensing a concentration or partial pressure of CO₂ in the patient'"'"'s blood or tissue;

(b) storing measures of said CO₂ concentration over time; and

(c) analyzing variations in said CO₂ concentration to determine if said patient is experiencing periodic breathing and to provide an indication of the progression of the disease state of said patient.

9. A method for monitoring the progression of the disease state of a heart failure patient comprising the steps of:

(a) sensing a physiologic signal indicative of arterial pulse amplitude of said patient to acquire a plurality of arterial pulse amplitude measures; and

(b) analyzing said arterial pulse amplitude measures to determine if said patient is experiencing periodic breathing and to provide an indication of the progression of the disease state of said patient.

10. The method of claim 9 wherein said step of analyzing includes the step of monitoring said measures for alternating decreases and increases in an average pulse amplitude.

11. The method of claim 9 wherein said step of analyzing includes the step of monitoring said measures for alternating loss and return of respiration-induced amplitude modulation.

12. The method of claim 9 wherein said step of analyzing includes the step of monitoring said measures for change in the variability of said arterial pulse amplitude.

13. A method for monitoring the progression of the disease state of a heart failure patient comprising the steps of:

(a) sensing a physiologic signal indicative of the arterial pulse of said patient to acquire a plurality of arterial pulse interval measures; and

(b) analyzing said arterial pulse interval measures to determine if said patient is experiencing periodic breathing and to provide an indication of the progression of the disease state of said patient.

14. The method of claim 13 wherein said step of analyzing includes the step of monitoring said measures for alternating decreases and increases in an average pulse interval.

15. The method of claim 13 wherein said step of analyzing includes the step of monitoring said measures for alternating loss and return of respiration-induced interval modulation.