Embolic devices capable of in-situ reinforcement

• US 6,602,269 B2
• Filed: 03/30/2001
• Issued: 08/05/2003
• Est. Priority Date: 03/30/2001
• Status: Expired due to Term

• Current Assignee: Stryker European Operations Holdings, LLC (Stryker Corporation)
• Original Assignee: Scimed Life Systems Incorporated (Boston Scientific Corporation)
• Inventors: Porter, Stephen Christopher, Wallace, Michael P.
• Primary Examiner(s): Calvert, John J.
• Assistant Examiner(s): Hurley, Shaun R
• Application Number:
  US09/822,918
• Publication Number:
  US 20020143348A1
• Time in Patent Office: 858 Days
• Field of Search: 606/108, 606/191, 606/192, 606/194, 606/195, 606/198, 606/200, 606/213, 604/30, 604/49, 604/52, 604/53, 604/96, 604/104, 604/264, 604/523
• US Class Current: 606/191
• CPC Class Codes: A61B 17/00491 Surgical glue applicators surgical adhesives A61L24/00; two-component delivery syringes A61M5/19
• CPC Class Codes: A61B 17/12022 Occluding by internal devices, e.g. balloons or releasable wires plugging an opening in the wall of an organ A61B17/0057; occluders for the cervical canal A61F6/146; vas deferens occluders A61F6/20
• CPC Class Codes: A61B 17/1214 Coils or wires
• CPC Class Codes: A61B 17/12172 having a pre-set deployed three-dimensional shape methods of manufacturing A61B2017/00526
• CPC Class Codes: A61B 17/12186 liquid materials adapted to be injected
• CPC Class Codes: A61B 2017/00004 (bio)absorbable, (bio)resorbable, resorptive for implantable prostheses A61F2210/0004
• CPC Class Codes: A61B 2017/00495 for two-component glue

Abstract

Described herein are embolic assemblies that can be reinforced in situ. In particular, assemblies are described comprising (i) an implantable device designed to allow injection of a liquid agent through the lumen of the device or a lumen defined by the device and (ii) an implantable device and a liquid agent, wherein the liquid agent is capable of solvating polymeric material of the device. Methods of making and using these assemblies are also provided.

Claims

1. A vaso-occlusive assembly, comprising

(a) an implantable device comprising a polymeric material and

(b) a liquid agent capable of at least partially solvating the polymeric material of the implantable device.

2. The assembly of claim 1, wherein the liquid agent is at least partially miscible with blood.

3. The assembly of claim 2, further comprising a radio-opaque material.

4. The assembly of claim 3, wherein the radio-opaque material is at least partially miscible with blood and at least partially miscible with the liquid agent.

5. The assembly of claim 1, wherein the polymeric material is selected from the group consisting of polyesters, polyethers, polyamides, polyfluorocarbons, polyethyleneterephthalate, polyurethanes, polyacrylics, polyvinlyl acetate, cellulose acetate, polyvinyl alcohols, polylactide, polyglycolide, poly(lactide-co-glycolide), poly(ecaprolactone), polyp-dioxanone), poly(lactide-co-trimethylene carbonate), polyhydroxybutyrate, polyhydroxyvalerate, polyanhydrides, and polyortoesters.

6. The assembly of claim 1, wherein the liquid agent is selected from the group consisting of propylene glycol, polyethylene glycols, ethanol, dimethyl sulfoxide, N-methyl-2-pyrrolidone, glycofuirol, Solketal, glycerol formal, acetone, tetrahydrofuirfitryl alcohol, diglyme, dimethyl isosorbide, and ethyl lactate.

7. The assembly of claim 1, wherein the polymeric material is coated onto the surface of the implantable device.

8. A method of occludina body cavity comprising introducing an assembly comprising (a) an implantable device comprising a polymeric material and (b) a liquid agent capable of at least partially solvating the polymeric material of the implantable device into the body cavity.

9. The method of claim 8, wherein when the polymeric material solidifies, the implantable device is thereby fused to one or more additional devices or to itself.