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N-maleimidyl polymer derivatives

  • US 6,602,498 B2
  • Filed: 02/21/2001
  • Issued: 08/05/2003
  • Est. Priority Date: 02/22/2000
  • Status: Expired due to Term
First Claim
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1. A multi-functional N-maleimidyl polymer derivative comprising a water soluble and non-peptidic polymer backbone having an average molecular weight from about 800 Da to about 100,000 Da, the polymer backbone having a first terminus bonded to a first functional group and a second terminus having a terminal carbon, wherein said terminal carbon of said second terminus is directly bonded to a N-maleimidyl moiety having the structure:

  • embedded imagewherein L is the point of bonding to the terminal carbon of the second terminus of the polymer backbone, said first functional group being different from said N-maleimidyl moiety bonded to the terminal carbon of said second terminus.

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