Non- or minimally invasive monitoring methods
First Claim
1. A sensor for measuring or detecting a target analyte, said sensor comprising an interface contact element that is capable of establishing an interface with a quantity of body fluid containing or suspected of containing the analyte, wherein said interface contact element is adapted to diffusion of the analyte essentially free of net mass fluid transport across said interface, characterized in that said interface contact element comprises an aqueous component that is isosmotic with the body fluid.
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Abstract
An apparatus for sensing an analyte is described, wherein the apparatus includes an interface contact element that is used to establish an interface with a quantity of body fluid. The interface contact element is adapted to facilitate diffusion of a target analyte across the interface essentially free of net mass fluid transport. The quantity of body fluid is exposed to the interface contact element through micro-pathways. The apparatus can also include a sensing material adapted to sense the target analyte with at least one analytical method. Methods for using the apparatus in a non- or minimally invasive monitoring technique are also described.
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Citations
28 Claims
- 1. A sensor for measuring or detecting a target analyte, said sensor comprising an interface contact element that is capable of establishing an interface with a quantity of body fluid containing or suspected of containing the analyte, wherein said interface contact element is adapted to diffusion of the analyte essentially free of net mass fluid transport across said interface, characterized in that said interface contact element comprises an aqueous component that is isosmotic with the body fluid.
- 5. A sensor for measuring or detecting a target analyte, said sensor comprising an interface contact element that is capable of establishing an interface with a quantity of body fluid containing or suspected of containing the analyte, wherein said interface contact element is adapted to diffusion of the analyte essentially free of net mass fluid transport across said interface, characterized in that said interface contact element comprises a specific concentration of the target analyte prior to being interfaced with the quantity of body fluid.
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17. A method for measuring or detecting a target analyte in a quantity of body fluid containing or suspected of containing the analyte, said method comprising:
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(a) exposing a quantity of body fluid through a micro-pathway created in a tissue surface;
(b) providing an interface contact element;
(c) establishing an interface at the tissue surface between the body fluid exposed through the micropathway and the interface contact element;
(d) allowing said analyte to diffuse across said interface into the interface contact element, wherein diffusion of the analyte occurs essentially free of net mass fluid transport across said interface; and
(e) measuring or detecting target analyte that has diffused into the interface contact element. - View Dependent Claims (18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
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Specification