×

Identification of compound-protein interactions using libraries of protein-nucleic acid fusion molecules

  • US 6,602,685 B1
  • Filed: 08/16/1999
  • Issued: 08/05/2003
  • Est. Priority Date: 08/17/1998
  • Status: Expired due to Term
First Claim
Patent Images

1. A method for detecting interactions between one or more compounds and one or more protein-nucleic acid fusions, said method comprising:

  • (a) providing a compound library which comprises a plurality of different compounds, wherein said compounds are immobilized on a solid support;

    (b) simultaneously contacting said different immobilized compounds in a single reaction chamber with a protein-nucleic acid fusion library which comprises a plurality of different protein-nucleic acid fusions under conditions which allow the formation of one or more compound-fusion complexes;

    (c) isolating said one or more immobilized compound-fusion complexes from unbound protein-nucleic acid fusions; and

    (d) detecting said one or more compound-fusion complexes as an indication that one or more protein-nucleic acid fusions interact with one or more compounds.

View all claims
  • 6 Assignments
Timeline View
Assignment View
    ×
    ×