T2 contrast in magnetic resonance imaging with gradient echoes

• US 6,603,989 B1
• Filed: 11/01/2000
• Issued: 08/05/2003
• Est. Priority Date: 03/21/2000
• Status: Expired due to Term

• Current Assignee: Dmitriy A. Yablonskiy
• Original Assignee: Dmitriy A. Yablonskiy
• Inventors: Yablonskiy, Dmitriy A.
• Primary Examiner(s): ROBINSON, DANIEL LEON
• Application Number:
  US09/704,285
• Time in Patent Office: 1,007 Days
• Field of Search: 600/410, 600/407, 600/408, 600/409, 600/411, 324/307, 324/308, 324/301, 436/173, 606/2, 606/20, 606/27, 606/32
• US Class Current: 600/410
• CPC Class Codes: G01R 33/50 based on the determination of relaxation times , e.g. T1 measurement by IR sequences; T2 measurement by multiple-echo sequences

Abstract

A method and apparatus for acquiring MR images is disclosed. The technique allows rapid acquisition of T2 weighted MR images using gradient echo imaging, and also allows the acquisition of T1 weighted or spin density images, T2* or T2′ weighted images all from the same data set. The technique includes determining a nonlinear function of gradient echo time to offset magnetic field inhomogeneities and acquiring multiple sets of MR data from a series of read-out gradient pulses in a pulse sequence. Both 2-D and 3-D pulse sequence embodiments are disclosed. The MR data is then fit to an equation that includes the nonlinear function and the images are reconstructed that include T1 or spin density weighting, T2 weighting images, T2*, or T2′ weighting. The resulting images are naturally co-registered.

Claims

1. A method of acquiring MR images comprising the steps of:

acquiring multiple sets of MR data from a series of read-out gradient pulses in a pulse sequence;

determining a nonlinear function of gradient echo time F(TE) to offset magnetic field inhomogeneities;

fitting the MR data to an equation that includes the nonlinear function F(TE); and

creating S(0) and T2 images using the results of the fitting step.

2. The method of claim 1 further comprising the step of creating a T2* image based on the same MR data used to create the S(0) and T2 images.

3. The method of claim 1 further comprising the step of creating a T2′

image based on the same MR data used to create the S(0) and T2 images.

4. The method of claim 1 further comprising the step of creating tissue blood volume and blood oxygenation level images based on the same MR data used to create the S(x,y;

0) and T2 images.

5. The method of claim 1 wherein the MR data is acquired with one of a two-dimensional multi-gradient echo imaging pulse sequence and a three-dimensional multi-gradient echo imaging pulse sequence.

6. The method of claim 1 wherein the step of determining a nonlinear function of gradient echo time F(TE) includes accounting for macroscopic magnetic field inhomogeneities.

7. The method of claim 1 wherein the step of determining a nonlinear function of gradient echo time F(TE) is generalized as:

8. The method of claim 7 further comprising approximating the generalized equation to one of:

9. The method of claim 7 further comprising approximating the generalized equation to:

$F<br><br>\left(\mathrm{TE}\right)=\sin <br><br>\left(\frac{\mathrm{\Delta <br><br>}<br><br>\text{\hspace{1em}<br><br>}<br><br>\mathrm{\omega <br><br>}·<br><br>\mathrm{TE}}{2}\right)/\left(\frac{\mathrm{\Delta <br><br>}<br><br>\text{\hspace{1em}<br><br>}<br><br>\mathrm{\omega <br><br>}·<br><br>\mathrm{TE}}{2}\right)$

where Δ

ω

is a frequency difference across a voxel.

10. The method of claim 7 further comprising approximating the generalized equation to:

11. The method of claim 1 wherein the equation that includes the nonlinear function is:

12. The method of claim 1 wherein the equation that includes the nonlinear function accounts for both macroscopic and mesoscopic field inhomogeneities and is given by:

13. The method of claim 1 wherein the S(x,y;

0) image is one of a spin density image and a T1 weighted image.

14. An MRI apparatus to rapidly acquire T2 weighted MR images using gradient echo imaging comprising:

a magnetic resonance imaging (MRI) system having a plurality of gradient coils positioned about a bore of a magnet to impress a polarizing magnetic field, an RF transceiver system, and an RF switch controlled by a pulse module to transmit and receive RF signals to and from an RF coil assembly to acquire MR images; and

a computer programmed to;

acquire multiple sets of MR data from a series of read-out gradient pulses in a pulse sequence;

determine signal intensity for each MR data;

fit the MR data to a signal magnitude equation that includes a nonlinear function; and

reconstruct T2 weighted MR images that are substantially free of magnetic field inhomogeneities.

15. The MRI apparatus of claim 14 wherein the MR images reconstructed include at least one of an S(0) image, a T2 image, and a T2* image.

16. The MRI apparatus of claim 15 wherein the S(0) image is one of a spin density and a T1 weighted image.

17. The MRI apparatus of claim 15 wherein the MR data is acquired with one of a two-dimensional multi-gradient echo imaging pulse sequence and a three-dimensional multi-gradient echo imaging pulse sequence.

18. The MRI apparatus of claim 15 wherein the nonlinear function is of gradient echo time F(TE) and is generalized as:

19. The MRI apparatus of claim 18 wherein the computer program approximates the generalized equation to one of:

20. The MRI apparatus of claim 18 wherein the computer program approximates the generalized equation to:

$F<br><br>\left(t\right)=\sin <br><br>\left(\frac{\mathrm{\Delta <br><br>}<br><br>\text{\hspace{1em}<br><br>}<br><br>\mathrm{\omega <br><br>}·<br><br>t}{2}\right)/\left(\frac{\mathrm{\Delta <br><br>}<br><br>\text{\hspace{1em}<br><br>}<br><br>\mathrm{\omega <br><br>}·<br><br>t}{2}\right)$

where Δ

ω

is a frequency difference across a voxel.

21. The MRI apparatus of claim 18 wherein the computer program approximates the generalized equation to:

22. The MRI apparatus of claim 14 further comprising:

a computer readable memory unit having stored therein a number of models for the nonlinear function;

a user input to receive an input identifying an object scanned; and

wherein the computer is further programmed to determine a model for the nonlinear function based on the object scanned.

23. The MRI apparatus of claim 14 wherein the MR images reconstructed are co-registered.

24. A computer program for use with an MRI apparatus comprising instructions which, when executed by a computer, cause the computer to:

apply a pulse sequence with a train of gradient read-out pulses;

acquire MR data during the train of gradient read-out pulses;

depending upon identification of an object scanned, determine a nonlinear function of gradient echo time;

fit signal magnitude of the MR data to a signal magnitude equation;

reconstruct MR images using results of the fit wherein the MR images reconstructed can include S(0) and T2 weighted images.

25. The computer program of claim 24 wherein the S(0) image includes either one of a spin density image and a T1 weighted image based on parameters of the pulse sequence.

26. The computer program of claim 24 wherein the MR images reconstructed can also include a T2* weighted image.

27. The computer program of claim 24 wherein the MR images reconstructed can also include a T2′

weighted image.

28. The computer program of claim 24 wherein the signal magnitude equation includes a nonlinear function of gradient echo time.

29. The computer program of claim 24 wherein the train of gradient read-out pulses extends to time TE_N, where TE_N is of length sufficient to acquire T2* weighted images.

30. The computer program of claim 28 wherein the nonlinear function is selected from a number of models based on the object scanned and MR hardware characteristics.