Stepped centering balloon for optimal radiation delivery
First Claim
1. A catheter for delivery of intravascular radiation therapy comprising:
- an elongate, tubular shaft, said shaft having a shaft diameter, and a lumen for receiving a radiation source; and
a balloon having a stepped centering segment attached to said elongate, tubular shaft, said stepped centering segment further comprising;
a central segment, said central segment having a first diameter and proximal and distal ends;
first step segments adjacent to each of said proximal and distal ends of said central segment;
offset segments adjacent to each of said first step segments, said offset segments having a second diameter; and
second step segments adjacent to each said offset segments and having a third diameter that is less than said second diameter.
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Accused Products
Abstract
A stepped centering catheter for delivery of intravascular radiation therapy including a central segment of a first effective diameter and smaller, offset segments of second effective diameters to each side of the central segment. The first effective diameter of the central segment substantially centers a portion of a radiation source within the lumen of a vessel along a therapeutic treatment length. The second effective diameters of the offset segments constrain portions of the radioactive source that extend beyond the therapeutic treatment length within a region having a minimum offset distance from the vessel wall. The first effective diameter of the central segment is gradually tapered to the second effective diameter of the offset segments across first steps. The second effective diameters of the offset segments are gradually tapered to the diameter of the catheter shaft across second steps. The smaller diameter offset segments and tapered change in diameters mitigates further injury to vessel walls located outside the therapeutic treatment length.
149 Citations
32 Claims
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1. A catheter for delivery of intravascular radiation therapy comprising:
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an elongate, tubular shaft, said shaft having a shaft diameter, and a lumen for receiving a radiation source; and
a balloon having a stepped centering segment attached to said elongate, tubular shaft, said stepped centering segment further comprising;
a central segment, said central segment having a first diameter and proximal and distal ends;
first step segments adjacent to each of said proximal and distal ends of said central segment;
offset segments adjacent to each of said first step segments, said offset segments having a second diameter; and
second step segments adjacent to each said offset segments and having a third diameter that is less than said second diameter. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A stepped centering balloon catheter for delivery of intravascular radiation therapy comprising:
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a tubular, elongate shaft, said shaft having a lumen for receiving a radiation source; and
a centering balloon segment attached to said tubular, elongate shaft, said centering balloon segment further comprising;
a central balloon segment, said central balloon segment having a first diameter and proximal and distal ends;
first balloon step segments adjacent to and continuous with each of said proximal and distal ends of said central balloon segment;
offset balloon segments, adjacent to and continuous with each of said first balloon step segments, said offset balloon segments having a second diameter; and
second balloon step segments adjacent to and continuous with each of said offset balloon segments and having a third diameter that is less than said second diameter. - View Dependent Claims (9, 10, 11, 12, 13, 14, 15, 16)
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17. A catheter for delivery of intravascular radiation therapy comprising:
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an elongate, tubular shaft, said shaft having a shaft diameter, and a lumen for receiving a radiation source; and
a balloon having a stepped centering segment attached to said elongate, tubular shaft, said stepped centering segment further comprising;
a central segment, said central segment having a first diameter and proximal and distal ends;
at least one first step segment adjacent to one of said proximal and distal ends of said central segment;
at least one offset segment adjacent to said at least one first step segment, said at least one offset segment having a second diameter; and
at least one second step segment adjacent to said at least one offset segment and having a third diameter that is less than said second diameter. - View Dependent Claims (18, 19, 20, 21, 22, 23, 24, 25, 26)
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27. A method for delivery of intravascular radiation therapy to an injured length of vessel comprising:
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substantially centering said injured length of vessel between a proximal and a distal marker on a stepped centering catheter, said proximal and distal markers defining a treatment length, said stepped centering catheter further comprising;
an elongate, tubular shaft, said shaft having a shaft diameter, and a lumen for receiving a radiation source; and
a balloon having a stepped centering segment attached to said elongate, tubular shaft, said stepped centering segment further comprising;
a central segment, said central segment having a first diameter and proximal and distal ends, wherein said central segment substantially radially centers portions of said radiation source between said proximal and distal markers within the vessel lumen;
first step segments adjacent to and continuous with each of said proximal and distal ends of said central segment, wherein said first step segments reduce said first diameter to the second diameters of offset segments;
offset segments adjacent to and continuous with said first step segments, said offset segments having a second diameter, wherein said second diameters offset portions of said radiation source that extend outside said proximal and distal markers a minimum distance from the vessel wall; and
second step segments adjacent to and continuous with said offset segments, wherein said second step segments reduce said second diameter to said shaft diameter. - View Dependent Claims (28, 29, 30, 31, 32)
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Specification