Conduit designs and related methods for optimal flow control

• US 6,605,053 B1
• Filed: 09/08/2000
• Issued: 08/12/2003
• Est. Priority Date: 09/10/1999
• Status: Expired due to Fees

• Current Assignee: Horizon Technology Funding Co. LLC (Horizon Technology Finance Management LLC)
• Original Assignee: Percardia, Inc.
• Inventors: Kamm, Roger D., Shim, Eun Bo
• Primary Examiner(s): Basichas, Alfred
• Application Number:
  US09/657,567
• Time in Patent Office: 1,068 Days
• Field of Search: 604/8, 604/9, 604/10, 604/129, 606/108, 623/1.3, 623/900, 623/903, 600/16, 128/898
• US Class Current: 604/8
• CPC Class Codes: A61B 2017/00252 for by-pass connections, i.e. connections from heart chamber to blood vessel or from blood vessel to blood vessel
• CPC Class Codes: A61F 2/06 Blood vessels
• CPC Class Codes: A61F 2/2493 Transmyocardial revascularisation [TMR] devices
• CPC Class Codes: G16H 50/50 for simulation or modelling of medical disorders

Abstract

A bypass conduit and related methods include implanting a bypass in the heart between a heart chamber and an at least partially occluded artery to directly flow blood from the chamber to the artery. The bypass conduit is configured to have a higher resistance to blood flow in a first direction than in a second direction without any active flow control mechanism. The bypass conduit may have a first end defining a first opening and a second end defining a second opening and a wall extending between the two ends that defines a lumen extending between the two openings. The ends and the wall of the conduit are configured to have a higher resistance to blood flow in a first direction than in a second direction. A method of bypassing an at least partially occluded artery includes determining a resistance to blood flow of the artery at a location of an at least partial occlusion and selecting a conduit having a configuration based on the resistance to blood flow of the artery at the location of the at least partial occlusion. The method further includes implanting the conduit in a heart wall between the heart chamber and the artery downstream of the at least partial occlusion to directly flow blood between the chamber and the artery.

Claims

1. A method of bypassing an at least partially occluded blood vessel, comprising:

determining a resistance to blood flow of the vessel at a location of an at least partial occlusion;

selecting a conduit having a configuration based on the resistance to blood flow of the vessel at the location of the at least partial occlusion; and

implanting the conduit in a heart wall between a heart chamber and the vessel downstream of the at least partial occlusion to directly flow blood between the chamber and the vessel.

2. The method of claim 1, wherein the selecting includes selecting a conduit having a higher resistance to blood flow in a direction from the vessel to the chamber than in a direction from the chamber to the vessel when the resistance to blood flow of the vessel at the location of the at least partial occlusion ranges from approximately 45 mmHg sec/ml to 76 mmHg sec/ml.

3. The method of claim 1, wherein the vessel is an artery.

4. The method of claim 3, wherein the chamber is a left ventricle.

5. A heart implant for bypassing an at least partially occluded blood vessel, the implant comprising:

a first end defining a vessel opening configured to be placed in flow communication with a blood vessel;

a second end opposite the first end and defining a chamber opening that is smaller than the vessel opening and configured to be placed in flow communication with a heart chamber; and

a wall extending between the first and second ends defining a lumen extending from the vessel opening to the chamber opening,

wherein said ends and said wall are configured such that the implant has a greater resistance to blood flow in a first direction from the vessel opening to the chamber opening than in a second direction from the chamber opening to the vessel opening, and

wherein the implant is configured to be positioned in the heart such that the second end is closer to the heart chamber than the first end is to the heart chamber.

6. The implant of claim 5, wherein the implant is configured to be positioned in a heart wall, and wherein the vessel opening is configured to be placed in flow communication with the blood vessel at a location downstream from an occlusion.

7. The implant of claim 5, wherein the chamber opening is configured to be placed in flow communication with a left ventricle.

8. The implant of claim 7, wherein the vessel opening is configured to be placed in flow communication with a coronary artery.

9. The implant of claim 5, wherein the vessel opening is configured to be placed in flow communication with a coronary artery.

10. The implant of claim 5, wherein a ratio of resistance to blood flow through the implant from the vessel to the chamber to resistance to blood flow through the implant from the chamber to the vessel is greater than approximately 1.1.

11. The implant of claim 5, wherein a ratio of resistance to blood flow through the implant from the vessel to the chamber to resistance to blood flow through the implant from the chamber to the vessel is approximately 2.

12. The implant of claim 5, wherein the vessel has a resistance to blood flow of at least approximately 45 mmHG sec/ml to approximately 76 mmHG sec/ml at a location of an occlusion.

13. The implant of claim 5, wherein the vessel opening is configured to be placed in flow communication with the at least partially occluded blood vessel.

14. A heart implant for bypassing an at least partially occluded blood vessel, comprising:

a first end defining a vessel opening configured to be placed in flow communication with a blood vessel;

a second end opposite the first end and defining a chamber opening that is smaller than the vessel opening and is configured to be placed in flow communication with a heart chamber; and

a wall extending between the first and second ends defining a lumen extending from the vessel opening to the chamber opening,

wherein the implant is configured to have a greater resistance to blood flow in a first direction from the vessel opening to the chamber opening than in a second direction from the chamber opening to the vessel opening without any active flow control mechanism, and

wherein the implant is configured to be positioned in the heart such that the second end is closer to the heart chamber than the first end is to the heart chamber.

15. The implant of claim 14, wherein the implant is configured to be positioned in a heart wall, and wherein the vessel opening is configured to be placed in flow communication with the blood vessel at a location downstream from an occlusion.

16. The implant of claim 14, wherein the chamber opening is configured to be placed in flow communication with a left ventricle.

17. The implant of claim 16, wherein the vessel opening is configured to be placed in flow communication with a coronary artery.

18. The implant of claim 14, wherein the vessel opening is configured to be placed in flow communication with a coronary artery.

19. The implant of claim 14, wherein a ratio of resistance to blood flow through the implant from the vessel to the chamber to resistance to blood flow through the implant from the chamber to the vessel is greater than approximately 1.1.

20. The implant of claim 14, wherein a ratio of resistance to blood flow through the implant from the vessel to the chamber to resistance to blood flow through the implant from the chamber to the vessel is approximately 2.

21. The implant of claim 14, wherein the vessel has a resistance to blood flow of at least approximately 45 mmHG sec/ml to approximately 76 mmHG sec/ml at a location of an occlusion.

22. The implant of claim 14, wherein the vessel opening is configured to be placed in flow communication with the at least partially occluded blood vessel.

23. A method for bypassing an at least partially occluded blood vessel, the method comprising:

providing an implant having a first end defining a vessel opening, a second end defining a chamber opening, and a wall defining a lumen extending from the vessel opening to the chamber opening, the chamber opening being smaller than the vessel opening; and

placing the vessel opening in flow communication with a blood vessel and the chamber opening in flow communication with a heart chamber, such that the second end is closer to the heart chamber than the first end is to the heart chamber and blood flows through the implant between the heart chamber and the blood vessel;

wherein the ends and the wall are configured such that the implant has a greater resistance to blood flow in a first direction from the vessel opening to the chamber opening than in a second direction from the chamber opening to the vessel opening.

24. The method of claim 23, further comprising positioning the implant in a heart wall.

25. The method of claim 23, wherein placing the vessel opening includes placing the vessel opening in flow communication with the blood vessel at a location downstream from an occlusion.

26. The method of claim 23, wherein placing the chamber opening includes placing the chamber opening in flow communication with a left ventricle.

27. The method of claim 26, wherein placing the vessel opening includes placing the vessel opening in flow communication with a coronary artery.

28. The method of claim 23, wherein placing the vessel opening includes placing the vessel opening in flow communication with a coronary artery.

29. The method of claim 23, wherein a ratio of resistance to blood flow through the implant from the vessel to the chamber to resistance to blood flow through the implant from the chamber to the vessel is greater than approximately 1.1.

30. The method of claim 23, wherein a ratio of resistance to blood flow through the implant from the vessel to the chamber to resistance to blood flow through the implant from the chamber to the vessel is approximately 2.

31. The method of claim 23, wherein the vessel has a resistance to blood flow of at least approximately 45 mmHG sec/ml to approximately 76 mmHG sec/ml at a location of an occlusion.

32. The implant of claim 23, wherein placing the vessel opening includes placing the vessel opening in flow communication with the at least partially occluded blood vessel.

33. A method for bypassing an at least partially occluded blood vessel, the method comprising:

providing an implant having a first end defining a vessel opening, a second end defining a chamber opening, and a wall defining a lumen extending from the vessel opening to the chamber opening, the chamber opening being smaller than the vessel opening; and

placing the vessel opening in flow communication with a blood vessel and the chamber opening in flow communication with a heart chamber, such that the second end is closer to the heart chamber than the first end is to the heart chamber and blood flows through the implant between the heart chamber and the blood vessel;

wherein the implant is configured to have a greater resistance to blood flow in a first direction from the vessel opening to the chamber opening than in a second direction from the chamber opening to the vessel opening without any active flow control mechanism.

34. The method of claim 33, further comprising positioning the implant in a heart wall.

35. The method of claim 33, wherein placing the vessel opening includes placing the vessel opening in flow communication with the blood vessel at a location downstream from an occlusion.

36. The method of claim 33, wherein placing the chamber opening includes placing the chamber opening in flow communication with a left ventricle.

37. The method of claim 36, wherein placing the vessel opening includes placing the vessel opening in flow communication with a coronary artery.

38. The method of claim 33, wherein placing the vessel opening includes placing the vessel opening in flow communication with a coronary artery.

39. The method of claim 33, wherein a ratio of resistance to blood flow through the implant from the vessel to the chamber to resistance to blood flow through the implant from the chamber to the vessel is greater than approximately 1.1.

40. The method of claim 33, wherein a ratio of resistance to blood flow through the implant from the vessel to the chamber to resistance to blood flow through the implant from the chamber to the vessel is approximately 2.

41. The method of claim 33, wherein the vessel has a resistance to blood flow of at least approximately 45 mmHG sec/ml to approximately 76 mmHG sec/ml at a location of an occlusion.

42. The implant of claim 33, wherein placing the vessel opening includes placing the vessel opening in flow communication with the at least partially occluded blood vessel.