Aromatic copolyester containing active ingredients

• US 6,605,069 B1
• Filed: 05/07/2001
• Issued: 08/12/2003
• Est. Priority Date: 11/12/1998
• Status: Expired due to Fees

• Current Assignee: Bayer AG
• Original Assignee: Bayer AG
• Inventors: Fröde, Rita, Hobler, Hartwin, Pudleiner, Heinz, Dujardin, Ralf, Simon, Joachim, Albers, Reinhard
• Primary Examiner(s): Page, Thurman K.
• Assistant Examiner(s): Sheikh, Humera N.
• Application Number:
  US09/831,232
• Time in Patent Office: 827 Days
• Field of Search: 424/405, 424/486, 424/400, 424/489, 424/497, 604/264, 604/265
• US Class Current: 604/264
• CPC Class Codes: A01N 25/10 Macromolecular compounds
• CPC Class Codes: A01N 25/34 Shaped forms, e.g. sheets, not provided for in any other sub-group of this main group
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 2300/406 Antibiotics
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 29/06 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 29/16 Biologically active materials, e.g. therapeutic substances A61L29/048 takes precedence
• CPC Class Codes: A61L 31/06 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds A61L31/041 takes precedence
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: A61P 31/04 Antibacterial agents
• CPC Class Codes: C08L 67/02 Polyesters derived from dicarboxylic acids and dihydroxy compounds C08L67/06 takes precedence

Abstract

The invention relates to aromatic copolyesters comprising antimicrobially active substances in homogeneous distribution, processes for their preparation and their use in medical articles.

Claims

1. A composition comprising:

(a) an aromatic copolyester that includes,

(i) 15-65 wt % of the copolyester of an ester unit of the formula (I)

wherein

R represents a divalent radical of a dicarboxylic acid which has a molecular weight of less than about 350,

D represents a divalent radical of an organic diol which has a molecular weight of less than about 250, and

(ii) 35-85 wt % of the copolyester of an ester unit of the formula (II)

wherein

R represents a divalent radical of a dicarboxylic acid which has a molecular weight of less than about 350,

G represents a divalent radical of a long-chain glycol which has an average molecular weight of about 350 to 6,000;

and

(b) at least one homogeneously distributed antimicrobially active substance selected from the group consisting of quinolones, aminoglycosides, macrolides, polypeptides lincomycins antimycobacterial agents, fusidic acid, nalidixic acid, pipemidic acid, cinoxacin, ciprofloxacin, norfloxacin, ofloxacin, pefloxacin, enoxacin, gentamycin, kanamycinm amikacin, sisomycin, tobramycin, netilmicin, erythromycin, clarithromycin, azithromycin, bacitracin, mupirocin, thrythricin, lincomycin, clindamycin and rifampicin.

2. A process for the preparation of the composition of claim 1 comprising, mixing homogeneously said antimicrobially active substance (b), and said aromatic copolyester (a).

6. A method of making a medical article comprising, molding the composition of claim 1 into the medical article.

7. The aromatic copolyester of the composition of claim 1, wherein the dicarboxylic acid comprises 8 to 16 carbon atoms.

8. The composition of claim 1, wherein the dicarboxic acid of said aromatic copolyester is selected from the group consisting of phthalic acid, terephthalic acid and isophthalic acid.

9. The composition of claim 1, wherein the organic diol of said aromatic copolyester comprises 2 to 15 carbon atoms.

10. The composition of claim 1, wherein the organic diol of said aromatic copolyester is selected from the group consisting of ethylene, propylene, tetramethylene, isobutylene, pentamethylene, 2,2-dimethyltnmethylene, hexamethylene and decamethylene glycols, dihydroxycyclohexane, cyclohexanedimethanol, resorcinol and hydroquinone.

11. The composition of claim 1, wherein the long chain glycol of said aromatic copolyester comprises 2 to 9 carbon atoms.

12. The composition of claim 1, wherein the long chain glycol of said aromatic copolyester is selected from the group consisting of glycol esters of poly-(alkylene oxide)-dicarboxylic acids or polyester glycols, polyformals, polythloether glycols, polybutadiene glycols and polyisoprene glycols.

3. A shaped article comprising:

(a) an aromatic copolyester that includes

(i) 15-65 wt % of the copolyester of an ester unit of the formula (I)

wherein

R represents a divalent radical of a dicarboxylic acid which has a molecular weight of less than about 350,

D represents a divalent radical of an organic diol which has a molecular weight of less than about 250, and

(ii) 35-85 wt % of the copolyester of an ester unit of the formula (II)

wherein

R represents a divalent radical of a dicarboxylic acid which has a molecular weight of less than about 350,

G represents a divalent radical of a long-chain glycol which has an average molecular weight of about 350 to 6,000;

and

(b) at least one homogeneously distributed antimicrobially active substance.

4. A thermoplastic molding composition comprising:

(a) an aromatic copolyester that includes,

(i) 15-65 wt % of the copolyester of an ester unit of the formula (I)

wherein

R represents a divalent radical of a dicarboxylic acid which has a molecular weight of less than about 350,

D represents a divalent radical of an organic diol which has a molecular weight of less than about 250, and

(ii) 35-85 wt % of the copolyester of an ester unit of the formula (II)

wherein

R represents a divalent radical of a dicarboxylic acid which has a molecular weight of less than about 350,

G represents a divalent radical of a long-chain glycol which has an average molecular weight of about 350 to 6,000;

and

(b) at least one homogeneously distributed antimicroblally active substance.

5. A molded article comprising the thermoplastic molding composition of claims 4.