Heparin delivery method

• US 6,605,114 B1
• Filed: 10/29/1999
• Issued: 08/12/2003
• Est. Priority Date: 04/24/1997
• Status: Expired due to Term

• Current Assignee: Advanced Cardiovascular Systems Incorporated (Abbott Laboratories)
• Original Assignee: Advanced Cardiovascular Systems Incorporated (Abbott Laboratories)
• Inventors: Yan, John Y., Chan, Randy
• Primary Examiner(s): Prebilic, Paul B.
• Application Number:
  US09/430,230
• Time in Patent Office: 1,383 Days
• Field of Search: 427/2.25, 623/1.15, 623/1.42, 623/1.43, 623/1.46, 623/23.71, 623/920, 623/921, 606/108, 606/191, 606/198, 128/898
• US Class Current: 623/1.43
• CPC Class Codes: A61F 2/0077 Special surfaces of prostheses, e.g. for improving ingrowth A61F2/30767 takes precedence
• CPC Class Codes: A61F 2/07 Stent-grafts
• CPC Class Codes: A61F 2/82 Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95; for closing wounds, or holding wounds closed A61B17/04 - A61B17/115; dilators A61M29/00
• CPC Class Codes: A61F 2/92 Stents in the form of a rolled-up sheet expanding after insertion into the vessel , e.g. with a spiral shape in cross-section
• CPC Class Codes: A61F 2002/072 Encapsulated stents, e.g. wire or whole stent embedded in lining
• CPC Class Codes: A61F 2002/075 the stent being loosely attached to the graft material, e.g. by stitching
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body
• CPC Class Codes: A61L 2420/08 Coatings comprising two or more layers
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 33/0011 Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
• CPC Class Codes: Y10S 623/921 Blood vessel

Abstract

A method for delivering heparin, wherein an implantable stent is coated with a material that attracts heparin and with which heparin forms a bond. The stent is exposed to a heparin containing solution just prior to implantation or is first implanted and then exposed to heparinized blood. As heparin becomes detached from the stent, the implantation site is exposed to heparin to restore an effective level and thereby prevent thrombosis.

Claims

1. A method of using an implantable support structure to transfer heparin to a specific site within a patient'"'"'s vasculature, comprising the steps of:

providing an implantable support structure, wherein said support structure is configured such that upon implantation in a blood vessel, such support structure has surfaces that face the vessel walls, surfaces that face the blood flow, and an upstream edge and a downstream edge;

depositing a coating exclusively on said edges that adheres thereto and that includes functional groups that attract heparin and to which heparin bonds;

implanting said support structure in said patient'"'"'s vasculature; and

exposing said implanted support structure to heparinized blood so as to attract heparin thereto.

2. The method of claim 1, wherein said coating is deposited on said support structure by dipping.

3. The method of claim 1, wherein said coating is deposited on said support structure by spraying.

4. The method of claim 1, wherein said coating is deposited on said support structure by molding.

5. The method of claim 1, wherein said coating is deposited on said support structure by plasma deposition.

6. The method of claim 1, wherein said coating is deposited by first depositing a base layer, selected for its ability to adhere to said support structure and then depositing thereon a top layer selected for its ability to bond to said base layer and avail said functional groups for attachment to said heparin.

7. The method of claim 1 further comprising the steps of repeatedly exposing said implanted support structure to heparinized blood in order to maintain a preselected heparin level on said stent.

8. A method using an implantable support structure to transfer heparin to a specific site within a patient'"'"'s vasculature, comprising the steps of:

providing an implantable support structure, wherein said support structure is configured such that upon implantation in a blood vessel, such support structure has surfaces that face the vessel walls, surfaces that face the blood flow, and an upstream edge and a downstream edge;

depositing a coating exclusively on said edges that adheres thereto and that includes functional groups that attract heparin and to which heparin adheres;

sterilizing and storing said support structure having said coating deposited thereon;

exposing said support structure to a heparin-containing solution prior to implantation so as to attract heparin thereto; and

implanting said support structure in said patient'"'"'s vasculature.

9. The method of claim 8, wherein said coating is deposited on said support structure by dipping.

10. The method of claim 8, wherein said coating is deposited on said support structure by spraying.

11. The method of claim 8, wherein said coating is deposited on said support structure by molding.

12. The method of claim 8, wherein said coating is deposited on said support structure by plasma deposition.

13. The method of claim 8, wherein said coating is deposited by first depositing a base layer, selected for its ability to adhere to said support structure and then depositing thereon a top layer selected for its ability to bond to said base layer and avail said functional groups for attachment to said heparin.

14. The method of claim 8 further comprising the steps of repeatedly exposing said implanted support structure to heparinized blood in order to maintain a preselected heparin level on said support structure.