Method and composition for inhibiting cardiovascular cell proliferation
First Claim
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1. A method for inhibiting trauma-induced intimal hyperplasia in a graft or vascular vessel receiving a graft, comprising:
- contacting a graft, prior to grafting, with a polymer consisting of from 6 to about 30 amino acid subunits in a pharmaceutically acceptable vehicle, wherein at least 50% of said subunits are arginine residues, and said polymer contains at least six contiguous arginine residues.
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Abstract
Cardiovascular cell proliferation in a blood vessel subjected to trauma, such as angioplasty, vascular graft, anastomosis, or organ transplant, can be inhibited by contacting the vessel with a polymer consisting of from 6 to about 30 amino acid subunits, where at least 50% of the subunits are arginine, and the polymer contains at least six contiguous arginine subunits. Exemplary polymers for this purpose include arginine homopolymers 7 to 15 subunits in length.
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Citations
28 Claims
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1. A method for inhibiting trauma-induced intimal hyperplasia in a graft or vascular vessel receiving a graft, comprising:
contacting a graft, prior to grafting, with a polymer consisting of from 6 to about 30 amino acid subunits in a pharmaceutically acceptable vehicle, wherein at least 50% of said subunits are arginine residues, and said polymer contains at least six contiguous arginine residues. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
- 27. A method of increasing NO production in a graft or vascular vessel receiving a graft, comprising contacting the graft, prior to grafting, with a polymer consisting of from 6 to about 30 amino acid subunits, wherein at least 50% of said subunits are arginine residues, and said polymer contains at least six contiguous arginine residues, in a pharmaceutically acceptable vehicle.
Specification