Method and system for determining at least one parameter of at least one sample of a physiological liquid, a holder and a test device

• US 6,605,471 B1
• Filed: 04/21/1999
• Issued: 08/12/2003
• Est. Priority Date: 05/30/1996
• Status: Expired due to Fees

• Current Assignee: Radiometer Medical ApS (Danaher Corporation)
• Original Assignee: Radiometer Medical ApS (Danaher Corporation)
• Inventors: Frischauf, Peter Aage, Lundsgaard, Finn C., Kagenow, Henrik, Andersen, Willy
• Primary Examiner(s): Warden, Jill
• Assistant Examiner(s): Bex, Kathryn
• Application Number:
  US09/194,372
• Time in Patent Office: 1,574 Days
• Field of Search: 422/55, 422/58, 422/61, 422/64, 422/81, 422/82.05, 422/82.08, 422/102, 422/104, 436/47, 436/45, 436/48, 436/63, 436/163, 436/164, 436/174, 436/165
• US Class Current: 436/165
• CPC Class Codes: G01N 2035/00277 Special precautions to avoid contamination (e.g. enclosures, glove- boxes, sealed sample carriers, disposal of contaminated material)
• CPC Class Codes: G01N 2035/00752 bar codes
• CPC Class Codes: G01N 2035/041 lifting items out of a rack for access
• CPC Class Codes: G01N 33/4925 measuring blood gas content, e.g. O2, CO2 , HCO3
• CPC Class Codes: G01N 35/025 having a carousel or turntable for reaction cells or cuvettes
• CPC Class Codes: Y10T 436/11 Automated chemical analysis
• CPC Class Codes: Y10T 436/111666 Utilizing a centrifuge or compartmented rotor
• CPC Class Codes: Y10T 436/113332 with conveyance of sample along a test line in a container or rack
• CPC Class Codes: Y10T 436/114165 with step of insertion or removal from test line
• CPC Class Codes: Y10T 436/25 including sample preparation

Abstract

The present invention relates to a method for determining at least one parameter of samples of physiological liquids, to test devices which may be used in the method, to a holder comprising a plurality of such test devices, and to a measuring apparatus adapted to accommodate the holder and to be used in the method and to a system comprising the apparatus and the holder.

Claims

1. A method for determining at least one parameter of at least one sample of a physiological liquid, the method comprising the steps of:

arranging a plurality of test devices in a holder, wherein each test device comprises a substantially sealed housing having a sample inlet port for entrance of the sample into the housing of the test device, and the housing comprising at least one measuring chamber adapted for measurement of the at least one parameter of the sample and an extending member positioned at the sample inlet port, the extending member having a surface that retains the physiological liquid, if spilled, on the extending member;

loading, to the at least one test device, the sample of the physiological liquid;

determining the at least one parameter of the sample loaded; and

discarding the holder with the at least one test device, retained in the holder wherein the at least one test device is substantially separated from the ambience.

2. The method according to claim 1, wherein a plurality of samples of physiological liquids are loaded into respective test devices of the plurality of test devices in the holder, and the holder is discarded with the plurality of test devices retained in the holder.

3. The method according to claim 1, wherein the at least one sample is loaded to the at least one test device from a sampling device or part thereof that conveys the at least one sample, and the sampling device or part thereof that conveys the at least one sample is received by the holder and discarded with the holder.

4. The method according to claim 1, wherein the at least one test device is transferred to an operational position prior to being loaded with the sample and further wherein test devices not occupying an operational position are retained in the holder and arc substantially separated from the ambience.

5. The method according to claim 1, wherein the at least one parameter of the sample is a blood gas parameter.

6. The method according to claim 5, wherein the blood gas parameter is pO₂, pCO₂, pH, hemoglobin, or derivatives of hemoglobin.