System and method for programmably controlling stimulation electrode configurations and activation sequence in a multi-site cardiac stimulation device

• US 6,606,516 B2
• Filed: 07/11/2001
• Issued: 08/12/2003
• Est. Priority Date: 04/12/2001
• Status: Expired due to Term

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated), Rapiscan Systems Incorporated (OSI Systems Incorporated)
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Inventors: Levine, Paul A.
• Primary Examiner(s): Getzow, Scott M.
• Application Number:
  US09/904,159
• Publication Number:
  US 20020151935A1
• Time in Patent Office: 762 Days
• Field of Search: 607/9-28
• US Class Current: 607/9
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/368 comprising more than one electrode co-operating with different heart regions A61N1/3622, A61N1/3627 take precedence
• CPC Class Codes: A61N 1/3684 for stimulating the heart at multiple sites of the ventricle or the atrium
• CPC Class Codes: A61N 1/36843 Bi-ventricular stimulation
• CPC Class Codes: A61N 1/3918 characterised by shock pathway, e.g. by electrode configuration

Abstract

An implantable multi-chamber cardiac stimulation device includes flexibly programmable electrode stimulation configurations, and is capable of precisely controlling the stimulation sequence between multiple sites. The stimulation device provides a plurality of connection ports that allow independent connection of each electrical lead associated with a particular stimulation site in the heart. Each connection port further provides a unique terminal for making electrical contact with only one electrode such that no two electrodes are required to be electrically coupled. Furthermore, each electrode, whether residing on a unipolar, bipolar or multipolar lead, may be selectively connected or disconnected through programmable switching circuitry that determines the electrode configurations to be used for sensing and for stimulating at each stimulation site. The stimulation device possesses unique sensing and output configurations associated with each stimulation site, such that depolarizations occurring at each stimulation site can be detected independently of events occurring at other sites within the heart, and such that each site can be stimulated independently of other sites or on a precisely timed basis triggered by events occurring at other sites. The stimulation device is further capable of uniquely programming coupling intervals for precisely controlling the activation sequence of stimulated sites. Coupling intervals are selected so as to provide optimal hemodynamic benefit to the patient.

Claims

1. A method of automatically configuring a plurality of stimulation electrodes that are positioned in multiple cardiac chambers, for use in a multi-site cardiac stimulation device, comprising the steps of:

defining a plurality of electrode configurations corresponding to a plurality of activation sequences of the stimulation electrodes;

detecting a first cardiac signal in one of the multiple cardiac chambers when cardiac signals are present;

delivering a first stimulus to one of the multiple chambers when cardiac signals are not present;

initiating coupling intervals for the multiple cardiac chambers based on the first cardiac signal that is detected or the first stimulus that is delivered;

setting an activation sequence of the stimulation electrodes by altering the electrode configurations based on the coupling intervals; and

delivering a second stimulus on demand, in any one or more of the cardiac chambers, in accordance with the activation sequence.

2. The method according to claim 1, further including the steps of:

measuring an amplitude of the first cardiac signal; and

automatically adjusting the coupling intervals in response to the first cardiac signal amplitude.

3. The method according to claim 2, wherein the step of detecting the first cardiac signal includes detecting the presence of an intrinsic right atrial depolarization;

and

delivering a right atrial stimulation pulse if no intrinsic right atrial depolarization is sensed.

4. The method according to claim 3, wherein the step of initiating coupling intervals includes initiating one or more coupling intervals from the right atrial stimulation pulse to any one or more of:

a left atrial stimulation pulse, a right ventricular stimulation pulse, or a left ventricular stimulation pulse.

5. The method according to claim 4, wherein, if an intrinsic right atrial depolarization is detected, initiating coupling intervals from the intrinsic right atrial depolarization to the left atrial stimulation pulse, the right ventricular stimulation pulse, and the left ventricular stimulation pulse.

6. The method according to claim 5, further including sensing for the presence of an intrinsic left atrial depolarization during a first coupling interval from the right atrial stimulation pulse to the left atrial stimulation pulse.

7. The method according to claim 6, wherein if an intrinsic left atrial depolarization is not detected during the first coupling interval, delivering a left atrial stimulation pulse;

and

if an intrinsic left atrial depolarization is detected during the first coupling interval, inhibiting the left atrial stimulation pulse.

8. The method according to claim 6, further including sensing for the presence of an intrinsic right ventricular depolarization during a second coupling interval from the right atrial stimulation pulse to the right ventricular stimulation pulse.

9. The method according to claim 8, wherein if an intrinsic right ventricular depolarization is not detected during the second coupling interval, delivering a right ventricular stimulation pulse;

and

if an intrinsic right ventricular depolarization is detected during the second coupling interval, inhibiting the right ventricular stimulation pulse.

10. The method according to claim 8, further including sensing for the presence of an intrinsic left ventricular depolarization during a third coupling interval from the right atrial stimulation pulse to the left ventricular stimulation pulse.

11. The method according to claim 10, wherein if an intrinsic left ventricular depolarization is not detected during the third coupling interval, delivering a left ventricular stimulation pulse;

and

if an intrinsic left ventricular depolarization is detected during the third coupling interval, inhibiting the left ventricular stimulation pulse.

12. The method according to claim 2, wherein the step of detecting the first cardiac signal includes detecting the presence of an intrinsic left atrial depolarization;

and

wherein, if an intrinsic left atrial depolarization is detected, initiating one or more coupling intervals from the intrinsic left atrial depolarization to any one or more of;

a right atrial stimulation pulse, a right ventricular stimulation pulse, or a left ventricular stimulation pulse.

13. The method according to claim 12, further including sensing for the presence of an intrinsic right atrial depolarization during a first coupling interval from the intrinsic left atrial depolarization to the right atrial stimulation pulse.

14. The method according to claim 13, wherein if an intrinsic right atrial depolarization is not detected during the first coupling interval, delivering a right atrial stimulation pulse;

and

if an intrinsic right atrial depolarization is detected during the first coupling interval, inhibiting the right atrial stimulation pulse.

15. The method according to claim 13, further including sensing for the presence of an intrinsic right ventricular depolarization during a second coupling interval from the intrinsic left atrial depolarization to the right ventricular stimulation pulse.

16. The method according to claim 15, wherein if an intrinsic right ventricular depolarization is not detected during the second coupling interval, delivering a right ventricular stimulation pulse;

and

if an intrinsic right ventricular depolarization is detected during the second coupling interval, inhibiting the right ventricular stimulation pulse.

17. The method according to claim 15, further including sensing for an intrinsic left ventricular depolarization during a third coupling interval from the intrinsic left atrial depolarization to the left ventricular stimulation pulse.

18. The method according to claim 17, wherein if an intrinsic left ventricular depolarization is not detected during the third coupling interval, delivering a left ventricular stimulation pulse;

and

if an intrinsic left ventricular depolarization is detected during the third coupling interval, inhibiting the left ventricular stimulation pulse.

19. The method according to claim 2, wherein the step of detecting the first cardiac signal includes detecting the presence of an intrinsic right ventricular depolarization;

and

delivering a right ventricular stimulation pulse if no intrinsic right ventricular depolarization is sensed.

20. The method according to claim 19, wherein the step of initiating coupling intervals includes initiating one or more coupling intervals from the right ventricular stimulation pulse to any one or more of:

a right atrial stimulation pulse, a left atrial stimulation pulse, or a left ventricular stimulation pulse.

21. The method according to claim 20, wherein, if an intrinsic right ventricular depolarization is detected, initiating coupling intervals from the intrinsic right ventricular depolarization to the right atrial stimulation pulse, the left atrial stimulation pulse, and the left ventricular stimulation pulse.

22. The method according to claim 21, further including sensing for the presence of an intrinsic right atrial depolarization during a first coupling interval from the right ventricular stimulation pulse to the right atrial stimulation pulse;

wherein if an intrinsic right atrial depolarization is not detected during the first coupling interval, delivering a right atrial stimulation pulse; and

if an intrinsic right atrial depolarization is detected during the first coupling interval, inhibiting the right atrial stimulation pulse.

23. The method according to claim 22, further including sensing for the presence of an intrinsic left atrial depolarization during a second coupling interval from the right ventricular stimulation pulse to the left atrial stimulation pulse;

wherein if an intrinsic left atrial depolarization is not detected during the second coupling interval, delivering a left atrial stimulation pulse; and

if an intrinsic left atrial depolarization is detected during the second coupling interval, inhibiting the left atrial stimulation pulse.

24. The method according to claim 23, further including sensing for the presence of an intrinsic left ventricular depolarization during a third coupling interval from the right ventricular stimulation pulse to the left ventricular stimulation pulse;

wherein if an intrinsic left ventricular depolarization is not detected during the third coupling interval, delivering a left ventricular stimulation pulse; and

if an intrinsic left ventricular depolarization is detected during the third coupling interval, inhibiting the left ventricular stimulation pulse.

25. The method according to claim 2, wherein the step of detecting the first cardiac signal includes detecting the presence of an intrinsic left ventricular depolarization;

delivering a left ventricular stimulation pulse if no intrinsic left ventricular depolarization is sensed; and

wherein, if an intrinsic left ventricular depolarization is detected, initiating coupling intervals from the intrinsic left ventricular depolarization to any one or more of;

a right ventricular stimulation pulse, a right atrial stimulation pulse, or a left atrial stimulation pulse.

26. The method according to claim 25, further including sensing for the presence of an intrinsic right atrial depolarization during a first coupling interval from the right ventricular stimulation pulse to the right atrial stimulation pulse;

wherein if an intrinsic right atrial depolarization is not detected during the first coupling interval, delivering a right atrial stimulation pulse; and

if an intrinsic right atrial depolarization is detected during the first coupling interval, inhibiting the right atrial stimulation pulse.

27. The method according to claim 26, further including sensing for the presence of an intrinsic right atrial depolarization during a second coupling interval from the left ventricular stimulation pulse to the right atrial stimulation pulse;

wherein if an intrinsic right atrial depolarization is not detected during the second coupling interval, delivering a right atrial stimulation pulse; and

if an intrinsic right atrial depolarization is detected during the second coupling interval, inhibiting the right atrial stimulation pulse.

28. The method according to claim 27, further including sensing for the presence of an intrinsic left atrial depolarization during a third coupling interval from the left ventricular stimulation pulse to the left atrial stimulation pulse;

wherein if an intrinsic left atrial depolarization is not detected during the third coupling interval, delivering a left atrial stimulation pulse; and

if an intrinsic left atrial depolarization is detected during the third coupling interval, inhibiting the left atrial stimulation pulse.

29. A multi-site cardiac stimulation device for automatically configuring a plurality of stimulation electrodes positioned in multiple cardiac chambers into a plurality of configurations that correspond to a plurality of activation sequences, the stimulation device comprising:

a discriminator, coupled to the plurality of stimulation electrodes, which is capable of detecting the presence of a cardiac signal in each of the cardiac chambers, and that identifies a cardiac chamber of origin in which the cardiac signal originates;

a pulse generator, connected to the stimulation electrodes, to selectively deliver a stimulation pulse to each of the cardiac chambers;

timing control circuitry, connected to the stimulation electrodes, the pulse generator, and the discriminator, to initiate coupling intervals for the multiple cardiac chambers based on the cardiac chamber of origin in which the cardiac signal is sensed or the stimulation pulse is delivered; and

a processor, responsive to the timing control circuitry, that sets an activation sequence of the stimulation electrodes by automatically adjusting the stimulation electrode configurations based on the coupling intervals.

30. The stimulation device according to claim 29, wherein the pulse generator delivers any one or more of a right atrial stimulation pulse, a right ventricular stimulation pulse, a left atrial stimulation pulse, or a left ventricular stimulation pulse, on demand, in accordance with the activation sequence, based on the expiration of the coupling intervals, in the absence of cardiac signals in the cardiac chambers.

31. The stimulation device according to claim 30, wherein the timing control circuitry further automatically adjusts the coupling intervals based on amplitude measurements of the cardiac signals acquired by the discriminator.

32. The stimulation device according to claim 31, wherein the timing control circuitry initiates any one or more coupling intervals from the right atrial stimulation pulse to any one or more of:

a left atrial stimulation pulse, a right ventricular stimulation pulse, or a left ventricular stimulation pulse.

33. The stimulation device according to claim 32, wherein, if the discriminator detects an intrinsic right atrial depolarization, the discriminator initiates coupling intervals from the intrinsic right atrial depolarization to any one or more of:

the left atrial stimulation pulse, the right ventricular stimulation pulse, or the left ventricular stimulation pulse.

34. The stimulation device according to claim 33, wherein the discriminator further senses for the presence of an intrinsic left atrial depolarization during a first coupling interval from the right atrial stimulation pulse to the left atrial stimulation pulse;

wherein if an intrinsic left atrial depolarization is not detected during the first coupling interval, the pulse generator delivers a left atrial stimulation pulse; and

if an intrinsic left atrial depolarization is detected during the first coupling interval, the processor inhibits the delivery of a left atrial stimulation pulse.

35. The stimulation device according to claim 34, wherein the discriminator further senses for the presence of an intrinsic right ventricular depolarization during a second coupling interval from the right atrial stimulation pulse to the right ventricular stimulation pulse;

wherein if an intrinsic right ventricular depolarization is not detected during the second coupling interval, the pulse generator delivers a right ventricular stimulation pulse; and

if an intrinsic right ventricular depolarization is detected during the second coupling interval, the processor inhibits the delivery of the right ventricular stimulation pulse.

36. The stimulation device according to claim 35, wherein the discriminator further senses for the presence of an intrinsic left ventricular depolarization during a third coupling interval from the right atrial stimulation pulse to the left ventricular stimulation pulse;

wherein if an intrinsic left ventricular depolarization is not detected during the third coupling interval, the pulse generator delivers a left ventricular stimulation pulse; and

if an intrinsic left ventricular depolarization is detected during the third coupling interval, the processor inhibits the delivery of the left ventricular stimulation pulse.

37. The stimulation device according to claim 32, wherein the discriminator senses for the presence of an intrinsic left atrial depolarization;

wherein, if an intrinsic left atrial depolarization is detected, the timing control circuitry initiates one or more coupling intervals from the intrinsic left atrial depolarization to any one or more of;

a right atrial stimulation pulse, a right ventricular stimulation pulse, or a left ventricular stimulation pulse.

38. The stimulation device according to claim 37, wherein the discriminator further senses for the presence of an intrinsic right atrial depolarization during a first coupling interval from the intrinsic left atrial depolarization to the right atrial stimulation pulse;

wherein if an intrinsic right atrial depolarization is not detected during the first coupling interval, the pulse generator delivers a right atrial stimulation pulse; and

wherein if an intrinsic right atrial depolarization is detected during the first coupling interval, the processor inhibits the delivery of a right atrial stimulation pulse.

39. The stimulation device according to claim 38, wherein the discriminator senses for the presence of an intrinsic right ventricular depolarization during a second coupling interval from the intrinsic left atrial depolarization to the right ventricular stimulation pulse;

wherein if an intrinsic right ventricular depolarization is not detected during the second coupling interval, the pulse generator delivers a right ventricular stimulation pulse; and

wherein if an intrinsic right ventricular depolarization is detected during the second coupling interval, the processor inhibits the delivery of the right ventricular stimulation pulse.

40. The stimulation device according to claim 39, wherein the discriminator senses for the presence of an intrinsic left ventricular depolarization during a third coupling interval from the intrinsic left atrial depolarization to the left ventricular stimulation pulse;

wherein if an intrinsic left ventricular depolarization is not detected during the third coupling interval, the pulse generator delivers a left ventricular stimulation pulse; and

wherein if an intrinsic left ventricular depolarization is detected during the third coupling interval, the processor inhibits the delivery of the left ventricular stimulation pulse.

41. The stimulation device according to claim 32, wherein the discriminator senses for the presence of an intrinsic right ventricular depolarization;

wherein, if an intrinsic right ventricular depolarization is detected, the timing control circuitry initiates one or more coupling intervals from the intrinsic right ventricular depolarization to any one or more of;

a right atrial stimulation pulse, a left atrial stimulation pulse, or a left ventricular stimulation pulse.

42. The stimulation device according to claim 41, wherein the discriminator further senses for the presence of an intrinsic right atrial depolarization during a first coupling interval from the right ventricular stimulation pulse to the right atrial stimulation pulse;

wherein if an intrinsic right atrial depolarization is not detected during the first coupling interval, the pulse generator delivers a right atrial stimulation pulse; and

wherein if an intrinsic right atrial depolarization is detected during the first coupling interval, the processor inhibits the delivery of the right atrial stimulation pulse.

43. The stimulation device according to claim 42, wherein the discriminator further senses for the presence of an intrinsic left atrial depolarization during a second coupling interval from the right ventricular stimulation pulse to the left atrial stimulation pulse;

wherein if an intrinsic left atrial depolarization is not detected during the second coupling interval, the pulse generator delivers a left atrial stimulation pulse; and

wherein if an intrinsic left atrial depolarization is detected during the second coupling interval, the processor inhibits the delivery of the left atrial stimulation pulse.

44. The stimulation device according to claim 43, wherein the discriminator further senses for the presence of an intrinsic left ventricular depolarization during a third coupling interval from the right ventricular stimulation pulse to the left ventricular stimulation pulse;

wherein if an intrinsic left ventricular depolarization is not detected during the third coupling interval, the pulse generator delivers a left ventricular stimulation pulse; and

wherein if an intrinsic left ventricular depolarization is detected during the third coupling interval, the processor inhibits the delivery of the left ventricular stimulation pulse.

45. The stimulation device according to claim 32, wherein the discriminator senses for the presence of an intrinsic left ventricular depolarization;

wherein, if an intrinsic left ventricular depolarization is detected, the timing and control circuitry initiates one or more coupling intervals from the intrinsic left ventricular depolarization to any one or more of;

a right ventricular stimulation pulse, a right atrial stimulation pulse, or a left atrial stimulation pulse.

46. The stimulation device according to claim 45, wherein the discriminator further senses for the presence of an intrinsic right atrial depolarization during a first coupling interval from the right ventricular stimulation pulse to the right atrial stimulation pulse;

wherein if an intrinsic right atrial depolarization is not detected during the first coupling interval, the pulse generator delivers a right atrial stimulation pulse; and

wherein if an intrinsic right atrial depolarization is detected during the first coupling interval, the processor inhibits the delivery of the right atrial stimulation pulse.

47. The stimulation device according to claim 46 wherein the discriminator further senses for the presence of an intrinsic right atrial depolarization during a second coupling interval from the left ventricular stimulation pulse to the right atrial stimulation pulse;

wherein if an intrinsic right atrial depolarization is not detected during the second coupling interval, the pulse generator delivers a right atrial stimulation pulse; and

wherein if an intrinsic right atrial depolarization is detected during the second coupling interval, the processor inhibits the delivery of the right atrial stimulation pulse.

48. The stimulation device according to claim 47, wherein the discriminator further senses for the presence of an intrinsic left atrial depolarization during a third coupling interval from the left ventricular stimulation pulse to the left atrial stimulation pulse;

wherein if an intrinsic left atrial depolarization is not detected during the third coupling interval, the pulse generator delivers a left atrial stimulation pulse; and

wherein if an intrinsic left atrial depolarization is detected during the third coupling interval, the processor inhibits the left atrial stimulation pulse.