Precise administration of a medicated aerosol via the lungs

• US 6,606,989 B1
• Filed: 04/03/2000
• Issued: 08/19/2003
• Est. Priority Date: 05/16/1997
• Status: Expired due to Term

• Current Assignee: Gsf-Forschungszentrum Fur Umwelt Und Gesundheit GmbH
• Original Assignee: Gsf-Forschungszentrum Fur Umwelt Und Gesundheit GmbH
• Inventors: Schulz, Holger, Brand, Peter, Heyder, Joachim, Roth, Christa, Selzer, Titus
• Primary Examiner(s): Lewis, Aaron J.
• Application Number:
  US09/423,909
• Time in Patent Office: 1,233 Days
• Field of Search: 128/200.16, 128/200.21, 128/203.13, 600/538
• US Class Current: 128/200.16
• CPC Class Codes: A61M 11/005 using ultrasonics spraying or atomising liquids using ultrasonic vibrations in general B05B17/06
• CPC Class Codes: A61M 15/00 Inhalators drug delivery in endotracheal tubes A61M16/04
• CPC Class Codes: A61M 15/008 Electronic counters
• CPC Class Codes: A61M 2016/0021 with a proportional output signal, e.g. from a thermistor
• CPC Class Codes: A61M 2016/0027 pressure meter
• CPC Class Codes: G01F 13/006 measuring volume in function of time

Abstract

A device for administration of a medicated aerosol via the lungs consists of an inhalation mouthpiece 11, with an associated adjustable vaporizer 12, and of a compressed-air control valve 14 through which a pre-settable (13) volumetric flow of compressed air can be discharged to the vaporizer 12 containing the liquid medicament throughout a settable period of time. For operation of the device an electronic controller is provided on which the vaporizing period of the vaporizer and a pause interval can be set, with provisions being made for triggering the beginning of the vaporizing operation by means of a pressure sensor responsive to a suction pressure in the mouthpiece.

Claims

1. A device for deposition of a medicament in a liquid form in the lungs, comprising:

an inhalation mouthpiece;

a pressure sensor responsive to a suction pressure in said mouthpiece to produce a triggering signal;

an adjustable vaporiser coupled to the inhalation mouthpiece and to receive a nozzle flow and a separate compressed-air flow, which vaporizer contains the medicament and delivers the vaporised medicament to the mouthpiece for a vaporising period in response to a vaporising signal;

a compressed-air control valve, which, in response to a valve signal, opens to allow the nozzle flow and the separate compressed-air flow to enter the vaporiser throughout the vaporising period to provide a predetermined inhaled volume, and closes at the end of the vaporising period to stop the nozzle flow and the separate compressed air flow;

a volumetric flow controller coupled to the compressed-air control valve to preset a determined quantity of a volumetric flow of the nozzle flow;

a flow meter disposed downstream of said volumetric flow controller for control of a predetermined volumetric flow; and

an electronic controller connected to receive the triggering signal from the pressure sensor to produce the valve signal and the vaporising signal, said electronic controller being configured with the settable vaporising period and a settable pause interval and operable to set the varporing period of the adjustable vaporiser to an invariable value from opening of the compressed-air control valve and causes a predetermined volume for each respiratory manoeuvre at the inhalation mouthpiece.

2. The device of claim 1 further comprising a compressed-air coupler connecting to a compressed-air line which is branched off between the compressed-air control valve and the volumetric flow controller for carrying the separate compressed air flow, wherein the compressed-air coupler stops the separate compressed air flow from entering the vaporiser if the vaporiser is configured as an ultrasonic transducer.

3. The device according to claim 1, wherein said volumetric flow controller is disposed upstream of said vaporiser which is adapted to be set in terms of time, for maintaining the volumetric flow constant.

4. The device according to claim 1, wherein said flow meter includes a floating body.

5. The device according to claim 1, wherein said electronic controller comprises a visible and/or audible pause signal to indicate the pause period between inhalation and exhalation.

6. The device according to claim 5, wherein said pause signal is generated by a light-emitting diode.

7. The device according to claim 1, wherein the number of vaporising periods is set in a form of a number of breathing cycles.

8. The device according to claim 1, wherein said vaporiser is configured in a form of an ultrasonic transducer issuing high frequency signals which are controllable by means of said electronic controller.

9. The device according to claim 1, wherein said compressed-air control valve is configured in the form of a solenoid valve.

10. The device according to claim 1 further comprising a pressure reducer and a pressure gauge disposed upstream of said compressed-air control valve.

11. A device for deposition of a medicament in a liquid form in the lungs, comprising:

an inhalation mouthpiece;

a pressure sensor responsive to a suction pressure in said mouthpiece to produce a triggering signal;

an adjustable vaporiser coupled to the inhalation mouthpiece and to receive a nozzle flow, which vaporizer contains the medicament and issues high frequencies to deliver the vaporised medicament to the mouthpiece for a vaporising period in response to a vaporising signal;

a compressed-air control valve, which, in response to a valve signal, opens to allow the nozzle flow to enter the vaporiser throughout the vaporising period to provide a predetermined inhaled volume, and closes at the end of the vaporising period to stop the nozzle flow;

a volumetric flow controller coupled to the compressed-air control valve to preset a determined quantity of a volumetric flow of the nozzle flow;

a flow meter disposed downstream of said volumetric flow controller for control of a predetermined volumetric flow; and

an electronic controller that receives the triggering signal from the pressure sensor to produce the valve signal and the vaporising signal, said electronic controller being configured with the settable vaporising period and a settable pause interval and controlling the high frequencies issued by the vaporizer and operable to set the varporing period of the adjustable vaporiser to an invariable value from opening of the compressed-air control valve and causes a predetermined volume for each respiratory manoeuvre at the inhalation mouthpiece.

12. The device according to claim 11, wherein said volumetric flow controller is disposed upstream of said vaporiser which is adapted to be set in terms of time, for maintaining the volumetric flow constant.

13. The device according to claim 11, wherein said electronic controller comprises a visible and/or audible pause signal to indicate the pause period between inhalation and exhalation.

14. The device according to claim 11, wherein said compressed-air control valve is configured in the form of a solenoid valve.

15. The device according to claim 11 further comprising a pressure reducer and a pressure gauge disposed upstream of said compressed-air control valve.

16. A method for administration of a medicated aerosol via lungs, comprising:

providing an adjustable vaporiser to vaporize a medication to be delivered through a mouthpiece for inhalation;

providing a controllable air flow via a compressed-air control valve to the adjustable vaporiser to produce the medicated aerosol and direct the medicated aerosol to the mouthpiece;

using a volumetric flow controller coupled to the compressed-air control valve to preset a determined quantity of a volumetric flow;

using a flow meter downstream of the compressed-air control valve to control the air flow at a constant flow rate;

using a pressure sensor at the mouthpiece to produce a triggering signal upon sensing a suction at the mouthpiece;

in response to the triggering signal, turning on the adjustable vaporizer to operate and opening the compressed-air control valve to allow the controllable air flow into the adjustable vaporiser, for a predetermined invariable vaporizing period; and

turning off both the adjustable vaporiser and the compressed-air control valve at the end of the vaporizing period to provide a predetermined constant volume of the medication for different respiratory manoeuvres.

17. The method as in claim 16, further comprising:

using an indicator light to signal to a patient to hold a breath after an inhalation; and

after expiration of a predetermined pause interval, using the indicator light to signal to the patient to exhale and thus to begin a subsequent inhalation cycle.

18. The method as in claim 16, further comprising adjusting a flow rate of the controllable air flow to change the predetermined constant volume of the medication.

19. The method as in claim 16, further comprising adjusting the predetermined invariable vaporizing period to change the predetermined constant volume of the medication.

20. The method as in claim 16, further comprising:

using the flow meter to initially control the air flow prior to setting the volumetric flow controller;

subsequently setting the volumetric flow controller to a desired setting; and

using an electronic controller to set the predetermined invariable vaporizing period to await the triggering signal to begin delivery of the medicated aerosol.