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Methods for the preparation of cellular hydrogels

  • US 6,608,117 B1
  • Filed: 05/11/2001
  • Issued: 08/19/2003
  • Est. Priority Date: 05/11/2001
  • Status: Active Grant
First Claim
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1. A method of preparing hydrogel sponges having collapsed walls, said method comprising the steps of:

  • (I) providing a polymer capable of being physically cross-linked;

    (II) dissolving said polymer in a material selected from the group consisting essentially of;

    (i) a single solvent for the polyvinyl alcohol and, (ii) a mixture of solvents for the polyvinyl alcohol, to form a solution;

    (III) mixing the solution formed in (II) with a pore-forming material;

    (IV) providing conditions for the mixture of (III) in which the polymer will undergo physical cross linking;

    (V) bringing the mixture from (IV) to about room temperature;

    (VI) removing essentially all of the solvents by a method which does not significantly affect the cross-linking or pore-forming material;

    (VII) heating the mixture at an elevated temperature for a period of from ten seconds to eight hours, and (VIII) cooling the mixture from (VII) to about room temperature and removing the pore-forming material by means which does not significantly affect the cross-linking, whereby a sponge having collapsed walls is obtained.

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