Method of treating the human eye with a wavefront sensor-based ophthalmic instrument

• US 6,609,794 B2
• Filed: 06/05/2001
• Issued: 08/26/2003
• Est. Priority Date: 06/05/2001
• Status: Expired due to Term

• Current Assignee: Northrop Grumman Systems Corporation (Northrop Grumman Corporation)
• Original Assignee: Adaptive Optics Associates Inc (Northrop Grumman Corporation)
• Inventors: Levine, Bruce Martin
• Primary Examiner(s): Lateef, Marvin M.
• Assistant Examiner(s): SANDERS JR, JOHN R
• Application Number:
  US09/874,903
• Publication Number:
  US 20030009156A1
• Time in Patent Office: 812 Days
• Field of Search: 351/200, 351/205, 351/206, 351/218, 351/221, 351/210, 351/212, 351/246
• US Class Current: 351/221
• CPC Class Codes: A61B 3/103 for determining refraction, e.g. refractometers, skiascopes
• CPC Class Codes: A61F 2009/00846 Eyetracking
• CPC Class Codes: A61F 2009/00848 based on wavefront
• CPC Class Codes: A61F 2009/00855 Calibration of the laser system
• CPC Class Codes: A61F 2009/00863 Retina
• CPC Class Codes: A61F 2009/00872 Cornea
• CPC Class Codes: A61F 2009/00882 based on topography
• CPC Class Codes: A61F 9/008 using laser

Abstract

An improved method for treating the eye includes the step of providing an ophthalmic instrument including an integral wavefront sensor. The wavefront sensor measures phase aberrations in reflections directed thereto to characterize aberrations of the eye. The wavefront sensor may be operably coupled to a display device, which displays a graphical representation of the aberrations of the eye. Such graphical representation may include: two dimensional contour maps that graphically depict contribution of pre-specified terms (such as spherical aberration, astigmatism and coma) for the aberrations of the eye, coefficients corresponding to such pre-specified terms that characterize the aberrations of the eye, or predefined two-dimensional icons that provide a general graphical depiction of such pre-specified terms. Such graphical representations provide the practitioner with valuable information characterizing the high order optical errors of the eye for use in diagnosis and treatment of abnormalities and disease in the eye. In addition, the wavefront sensor may be part of an adaptive optical subsystem that compensates for the phase aberrations measured therein to provide phase-aligned images of the eye for capture by an image capture subsystem. Such images may be used by practitioner in diagnosis and treatment of abnormalities and disease in the eye.

Claims

1. A method for treating an eye of a human patient, comprising the steps of:

providing an ophthalmic instrument having an optical axis and an integral wavefront sensor disposed along said optical axis;

aligning said optical axis with said eye;

illuminating the eye with light produced from a light source and enabling said wavefront sensor to perform wavefront sensing operations that measure high order aberrations of said eye;

displaying a graphical representation of said high order aberrations of said eye measured by said wavefront sensor; and

treating said eye to correct for said high order aberrations of said eye;

wherein said graphical representation comprises coefficients corresponding to pre-specified terms that characterize aberrations of said eye; and

wherein said graphical representation further comprises predefined two-dimensional icons that provide a general graphical depiction of said pre-specified terms.

2. The method of claim 1, wherein the displaying step is performed on a display device integral to said ophthalmic instrument.

3. The method of claim 2, wherein said display device comprises a TFT LCD device.

4. The method of claim 1, wherein said graphical representation comprises two dimensional contour maps that graphically depict contribution of pre-specified terms for aberrations of said human eye.

5. The method of claim 1, wherein said graphical representation comprises coefficients corresponding to pre-specified terms that characterize aberrations of said human eye.

6. The method of claim 5, wherein said pre-specified terms characterize defocus, spherical aberration, coma and astigmatism of said aberrations.

7. The method of claim 1, wherein said ophthalmic instrument is configured as a desktop instrument.

8. The method of claim 1, wherein said ophthalmic instrument is configured as a hand-held instrument.

9. The method of claim 1, wherein the step of treating said eye comprises the step of supplying a lens to said human patient that corrects for said high order aberrations.

10. The method of claim 9, wherein the step of treating said eye comprises the step of selecting a pre-fabricated lens that corrects for said high order aberrations and supplying the selected pre-fabricated lens to said human patient.

11. The method of claim 9, wherein the step of treating said eye comprises the step of fabricating a custom lens that corrects for said high order aberrations and supplying the custom lens to said human patient.

12. The method of claim 1, wherein the step of treating said eye comprises the step of surgically treating said eye to correct for said high order aberrations.

13. The method of claim 1, wherein the aligning step comprises the step of aligning said optical axis to said eye.

14. The method of claim 1, wherein the aligning step comprises the-step of aligning said eye to said optical axis.

15. A method for treating a human eye, comprising the steps of:

providing an ophthalmic instrument having an optical axis and an integral wavefront sensor disposed along said optical axis;

aligning the optical axis of said ophthalmic instrument with said human eye;

illuminating said human eye with light produced from a light source and enabling said wavefront sensor to perform wavefront sensing operations that measure high order aberrations of said human eye;

displaying a graphical representation of said high order aberrations of said human eye measured by said wavefront sensor; and

treating said human eye to correct for said high order aberrations of said human eye;

wherein said graphical representation comprises coefficients corresponding to pre-specified terms that characterize aberrations of said human eye;

wherein said ophthalmic instrument is configured as a hand-held binocular instrument having two channels, and

wherein each said channel has a separate wavefront sensor.

16. A method for treating a human eye, comprising the steps of:

providing an ophthalmic instrument having an optical axis and an integral wavefront sensor disposed along said optical axis;

calibrating said wavefront sensor;

aligning said optical axis with said human eye;

illuminating said human eye with light produced from a light source and enabling said wavefront sensor to perform wavefront sensing operations that measure high order aberrations of said human eye;

displaying a graphical representation of said high order aberrations of said human eye measured by said wavefront sensor;

treating said human eye to correct for said high order aberrations of said human eye; and

wherein said graphical representation comprises coefficients corresponding to pre-specified terms that characterize aberrations of said human eye;

wherein said wavefront sensor comprises a relay lens operably coupled between a lenslet array and an imaging device, and

wherein said relay lens and imaging device are aligned along said optical axis and mounted on a moveable stage that translates linearly along said optical axis.

17. The method of claim 16, wherein said lenslet array comprises an array of lenslets and said imaging device has non-overlapping subapertures, and

wherein each said lenslet comprises a reference fiducial point that contributes to a reference spot pattern imaged by said relay lens onto said imaging device in a calibration mode.

18. The method of claim 17, wherein a reference null position, for calculating the movement of a spot in a test spot pattern produced from a given lenslet, is derived from the location of a spot in said reference spot pattern produced from the given lenslet.

19. The method of claim 17, wherein during said calibration mode, said non-overlapping subapertures are dynamically assigned to lenslets in said lenslet array for use in tracking the movement of spots in said test spot pattern.

20. The method of claim 17, wherein during said calibration mode, said non-overlapping subaperatures are dynamically assigned to particular lenslets in said lenslet array for use in tracking the movement of spots in said test spot pattern, and wherein each particular lenslet corresponds to a single spot in both said reference spot pattern and said test spot pattern.

21. A method for treating an eye of a human patient, comprising the steps of:

providing an ophthalmic imaging instrument having an optical axis and an integral adaptive optical subsystem disposed along said optical axis;

aligning said optical axis with said eye;

illuminating said eye with light produced from a light source and enabling said adaptive optical subsystem to perform wavefront sensing and compensation operations;

concurrently with said wavefront sensing and compensation operations performed by said adaptive optical subsystem, capturing an image of said eye derived from compensation by said adaptive optical subsystem; and

displaying a graphical representation of high order aberrations of said eye measured by said adaptive optical subsystem;

wherein said graphical representation comprises coefficients corresponding to pre-specified terms that characterize aberrations of said eye; and

wherein said graphical representation comprises predefined two-dimensional icons that provide a general graphical depiction of said pre-specified terms.

22. The method of claim 21, wherein said image of said eye comprises a photograph.

23. The method of claim 21, wherein said image of said eye is a digital image captured by an image sensor.

24. The method of claim 21, further comprising the step of treating said human eye to correct for said high order aberrations of said eye.

25. The method of claim 21, wherein the displaying step is performed on a display device integral to said ophthalmic imaging instrument.

26. The method of claim 25, wherein said display device comprises a TFT LCD device.

27. The method of claim 21, wherein said graphical representation comprises two dimensional contour maps that graphically depict contribution of pre-specified terms for aberrations of said eye.

28. The method of claim 21, wherein said graphical representation comprises coefficients corresponding to pre-specified terms that characterize aberrations of said eye.

29. The method of claim 28, wherein said pre-specified terms characterize defocus, spherical aberration, coma and astigmatism of said aberrations.

30. The method of claim 21, wherein said ophthalmic imaging instrument is configured as a desktop instrument.

31. The method of claim 21, wherein said ophthalmic imaging instrument is configured as a hand-held instrument.

32. The method of claim 21, wherein said ophthalmic imaging instrument is configured as a hand-held binocular instrument having two channels, and wherein each said channel has a separate adaptive optical subsystem.

33. The method of claim 21, wherein the step of treating said eye comprises the step of supplying a lens that corrects for said high order aberrations.

34. The method of claim 33, wherein the step of treating said eye comprises the step of selecting a pre-fabricated lens that corrects for said high order aberrations and supplying the selected per-fabricated lens to said human patient.

35. The method of claim 33, wherein the step of treating said eye comprises the step of fabricating a custom lens that corrects for said high order aberrations and supplying the custom lens to said human patient.

36. The method of claim 21, wherein the step of treating said eye comprises the step of surgically treating said eye to correct for said high order aberrations.

37. The method of claim 21, wherein the aligning step comprises the step of aligning said optical axis to said eye.

38. The method of claim 21, wherein the aligning step comprises the step of aligning said eye to said optical axis.

39. A method for treating a human eye, comprising the steps of:

providing an ophthalmic imaging instrument having an optical axis and an integral adaptive optical subsystem disposed along said optical axis, and said adaptive optical subsystem including a wavefront sensor;

calibrating said wavefront sensor associated with said adaptive optical subsystem;

aligning said optical axis with said human eye;

illuminating said human eye with light produced from a light source and enabling said adaptive optical subsystem to perform wavefront sensing and compensation operations; and

concurrently with said wavefront sensing and compensation operations performed by said adaptive optical subsystem, capturing an image of the eye derived from compensation by the adaptive optical subsystem;

wherein said wavefront sensor comprises al relay lens operably coupled between a lenslet array and an imaging device, and

wherein said relay lens and said imaging device are aligned along said optical axis and mounted on a moveable stage that translates linearly along said optical axis.

40. The method of claim 39, wherein said lenslet array comprises an array of lenslets and said imaging device has non-overlapping subapertures, and

wherein each said lenslets comprises a reference fiducial point that contributes to a reference spot pattern imaged by said relay lens onto said imaging device in a calibration mode.

41. The method of claim 40, wherein a reference null position, for calculating the movement of a spot in a test spot pattern produced from a given lenslet, is derived from the location of a spot in said reference spot pattern produced from the given lenslet.

42. The method of claim 41, wherein during said calibration mode said non-overlapping subaperatures are dynamically assigned to lenslets in said lenslet array for use in tracking the movement of spots in said test spot pattern.

43. The method of claim 41, wherein during said calibration mode, said non-overlapping subaperatures are dynamically assigned to particular lenslets in said lenslet array for use in tracking the movement of spots in said test spot pattern, and

wherein each particular lenslet corresponds to a single spot in both said reference spot pattern and said test spot pattern.