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System and method for intranasal administration of lorazepam

  • US 6,610,271 B2
  • Filed: 02/20/2001
  • Issued: 08/26/2003
  • Est. Priority Date: 05/10/2000
  • Status: Expired due to Fees
First Claim
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1. A pharmaceutical composition for intranasal administration to a mammal that produces a sedative-anxiolytic physiological response in the mammal, the composition consisting essentially of:

  • lorazepam;

    polyethylene glycol and propylene glycol as a solvent-carrier for the lorazepam;

    wherein the polyethylene glycol constitutes from about 15% to about 25% by volume and the propylene glycol constitutes from about 75% to about 85% by volume of the composition; and

    a sweetener, wherein the composition forms a spray when discharged from a manually actuated spray device.

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