Compositions for the delivery of antigens
First Claim
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1. A composition comprising:
- (a) an antigen;
(b) an adjuvant;
(c) at least one carrier comprising a member selected from the groups consisting of;
(i) an acylated amino acid or a salt thereof;
(ii) a poly amino acid comprising at least one acylated amino acid or a salt thereof;
(iii) a sulfonated amino acid or a salt thereof;
(iv) a poly amino acid comprising at least one sulfonated amino acid or a salt thereof;
or (v) any combination thereof.
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Abstract
The present invention relates to compositions and methods for orally delivering antigens. The antigen and an adjuvant are combined with an acylated amino acid or polyamino acid and, a sulfonated amino acids or polyamino acid, or a salt of the foregoing.
82 Citations
14 Claims
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1. A composition comprising:
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(a) an antigen;
(b) an adjuvant;
(c) at least one carrier comprising a member selected from the groups consisting of;
(i) an acylated amino acid or a salt thereof;
(ii) a poly amino acid comprising at least one acylated amino acid or a salt thereof;
(iii) a sulfonated amino acid or a salt thereof;
(iv) a poly amino acid comprising at least one sulfonated amino acid or a salt thereof;
or(v) any combination thereof. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
(A) a composition according to claim 1; - and
(B) (a) an excipient, (b) a diluent, (c) a disintegrant, (d) a lubricant, (e) a plasticizer, (f) a colorant, (g) a dosing vehicle, or (h) any combination thereof.
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12. A dosage unit form according to claim 11 comprising a tablet, a capsule, or a liquid.
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13. A method for administering an antigen to an animal, said method comprising orally administering a composition as defined in claim 1.
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14. A method for preparing a composition as defined in claim 1, said method comprising mixing an antigen, an adjuvant, and a carrier comprising a member selected from the group consisting of:
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(i) an acylated amino acid or a salt thereof;
(ii) a poly amino acid comprising at least one acylated amino acid or a salt thereof;
(iii) a sulfonated amino acid or a salt thereof;
(iv) a poly amino acid comprising at least one sulfonated amino acid or a salt thereof;
or(v) any combination thereof.
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Specification