Method of treating inflammatory conditions with progesterone analogs

• US 6,610,674 B1
• Filed: 09/08/2000
• Issued: 08/26/2003
• Est. Priority Date: 09/28/1999
• Status: Expired due to Fees

• Current Assignee: University of Pennsylvania
• Original Assignee: University of Pennsylvania
• Inventors: Schreiber, Alan D.
• Primary Examiner(s): Padmanabhan, Sreeni
• Assistant Examiner(s): JIANG, SHAOJIA A
• Application Number:
  US09/658,867
• Time in Patent Office: 1,082 Days
• Field of Search: 514/177, 514/178, 514/181
• US Class Current: 514/177
• CPC Class Codes: A61K 31/57 substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
• CPC Class Codes: A61P 1/00 Drugs for disorders of the alimentary tract or the digestive system
• CPC Class Codes: A61P 1/04 for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
• CPC Class Codes: A61P 17/06 Antipsoriatics
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 37/08 Antiallergic agents antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14
• CPC Class Codes: A61P 9/14 Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Abstract

The present invention provides methods for treating inflammatory conditions, including but not limited to, inflammatory bowel disease (ulcerative colitis, Crohn'"'"'s disease, and proctitis), other noninfectious, inflammatory conditions of the GI tract (microscopic colitis, allergic eosinophilic gastroenteritis, food allergies, pill induced esophagitis, celiac disease, recurrent polyps, and hemorrhoids), and psoriasis, using progesterone or progesterone analogs such as medroxyprogesterone acetate.

Claims

1. A method of treating a patient suffering from at least one of the following inflammatory conditions:

ulcerative colitis, Crohn'"'"'s disease, proctitis, microscopic colitis, allergic eosinophilic gastroenteritis, food allergies, pill induced esophagitis, celiac disease, recurrent polyps, and hemorrhoids, wherein a progesterone analog is selected from medroxyprogesterone acetate and said progesterone analog is administered to the patient.

2. The method of claim 1, wherein the patient is treated with medroxyprogesterone acetate once a day.

3. The method of claim 1, wherein the patient is treated with from about 500 mg to about 2 grams of medroxyprogesterone acetate daily.

4. The method of claim 1, wherein the medroxyprogesterone acetate is administered orally.

5. The method of claim 1, wherein the patient is suffering from at least one of the following inflammatory conditions of the patient'"'"'s gastrointestinal tract:

ulcerative colitis, Crohn'"'"'s disease, proctitis, microscopic colitis, allergic eosinophilic gastroenteritis, food allergies, recurrent polyps, and hemorrhoids.

6. The method of claim 5, wherein the medroxyprogesterone acetate is formulated in an entedc coated tablet to allow for targeted delivery to an affected portion of the gastrointestinal tract.

7. The method of claim 5, wherein the medroxyprogesterone acetate is administered rectally using a composition chosen from an enema, a suppository, a foam, a cream, a gel, an ointment, and a suspension.