Phase dispersive tomography

• US 6,611,339 B1
• Filed: 06/09/2000
• Issued: 08/26/2003
• Est. Priority Date: 06/09/2000
• Status: Expired due to Fees

• Current Assignee: Massachusetts Institute of Technology
• Original Assignee: Massachusetts Institute of Technology
• Inventors: Wax, Adam, Yang, Changhuei, Feld, Michael S.
• Primary Examiner(s): Turner, Samuel A.
• Assistant Examiner(s): CONNOLLY, PATRICK J
• Application Number:
  US09/591,297
• Time in Patent Office: 1,173 Days
• Field of Search: 356/496, 356/497, 356/479, 356/489
• US Class Current: 356/485
• CPC Class Codes: A61B 5/0066 Optical coherence imaging
• CPC Class Codes: A61B 5/0073 by tomography, i.e. reconstruction of 3D images from 2D projections A61B5/0066 takes precedence
• CPC Class Codes: G01N 15/0205 by optical means
• CPC Class Codes: G01N 21/4795 spatially resolved investigating of object in scattering medium in vivo A61B

Abstract

Radiation that propagates undeflected through a turbid medium, undergoes a small change in phase velocity due to its wave nature. This change can be measured using a differential phase optical interferometer. Ballistic propagation can be classified into three regimes: For scatterers small compared to the wavelength, the turbid medium acts as a bulk medium; for large scatterers, phase velocity is independent of turbidity; and in the intermediate regime the phase velocity is strongly dependent on scatterer radius. In particular, for scatterers having intermediate size a phase velocity increase and negative dispersion is observed by adding positive dispersion scatterers of higher refractive index. These measurements are made using the phase difference between fundamental and harmonic light and can be used to provide diagnostic information and images of tissue or biological fluids.

Claims

1. A method for optically measuring tissue comprising:

providing a first wavelength and a second wavelength of light such that the second wavelength is harmonically related to the first wavelength;

directing light of the first wavelength and the second wavelength along both a first optical path and a second optical path, the first optical path extending onto the tissue to be measured and the second path undergoing a change in path length; and

detecting light from the tissue and light from the second optical path to measure a change in phase of light interacting with the tissue.

2. The method of claim 1 wherein the tissue comprises human tissue.

3. The method of claim 1 further comprising determining a size of a particle within the medium.

4. The method of claim 1 further comprising forming an image of the medium with the detected scattered light.

5. The method of claim 1 further comprising measuring a change in phase velocity of light interacting with the medium.

6. The method of claim 1 further comprising providing light source that emits the first wavelength and a second wavelength that are harmonically related.

7. The method of claim 1 further comprising providing a first low coherence light source and a second low coherence light source.

8. The method of claim 1 further comprising providing a low coherence light source and a coherent light source.

9. The method of claim 1 wherein the second wavelength is within 5% of an integer multiple of the first wavelength.

10. The method of claim 1 further comprising providing a detector system connected to a data processor, the data processor determining characteristics of the tissue.

11. A method for optically measuring biological tissue comprising:

providing a first wavelength and a second wavelength of light such that the second wavelength is harmonically related to the first wavelength;

providing a detector system connected to a data processor;

directing light of the first wavelength and the second wavelength along both a first optical path and a second optical path, the first optical path extending onto the tissue to be measured and the second path undergoing a change in path length;

detecting light from the tissue and light from the second optical path with the detector system to measure a change in phase of light interacting with the tissue; and

determining a characteristic of the tissue with the data processor using the measured change in phase.

12. The method of claim 11 further comprising determining a size of a particle within the medium.

13. The method of claim 11 further comprising forming an image of the medium with the detected scattered light.

14. The method of claim 11 further comprising measuring a change in phase velocity of light interacting with the medium.

15. The method of claim 11 further comprising providing light source that emits the first wavelength and a second wavelength that are harmonically related.

16. The method of claim 11 further comprising providing a first low coherence light source and a second low coherence light source.

17. The method of claim 11 further comprising providing a low coherence light source and a coherent light source.

18. The method of claim 11 wherein the second wavelength is within 5% of an integer multiple of the first wavelength.

19. The method of claim 11 further comprising providing a compensator and a scanning mirror along the second optical path.

20. The method of claim 11 wherein the step of providing a detector system comprises providing a first detector that detects the first wavelength and a second detector that measures the second wavelength.

21. The method of claim 11 further comprising coupling light from a light source to the tissue with a fiber optic device.

22. A device for optically measuring a medium comprising:

a light source that provides a first wavelength and a second wavelength of light such that the second wavelength harmonically related to the first wavelength;

an optical system that couples light of the first wavelength and the second wavelength along both a first optical path and a second optical path, the first optical path extending onto a medium to be measured and the second path undergoing a change in path length; and

a detector that detects light from the medium and light from the second optical path to measure a change in phase of light interacting with the medium.

23. The device of claim 22 wherein the medium comprises biological tissue.

24. The device of claim 22 further comprising a data processor that determines a size of a particle within the medium.

25. The device of claim 22 further comprising a data processor that forms an image of the medium with the detected scattered light.

26. The device of claim 22 further comprising a data processor that determines a change in phase velocity of light interacting with the medium.

27. The device of claim 22 wherein the light source emits light in the visible and near-infrared regions.

28. The device of claim 22 further comprising providing a first low coherence light source and a second low coherence light source.

29. The device of claim 22 further comprising providing a low coherence light source and a coherent light source.

30. The device of claim 22 wherein the second wavelength is within 5% of an integer multiple of the first wavelength.

31. The device of claim 22 further comprising a fiber optic device that couples light from the light source on the medium.

32. The device of claim 22 further comprising a fiber optic device that couples light from the medium to the detector.

33. The device of claim 22 wherein the detector comprises a first photodetector and a second photodetector.

34. The device of claim 22 further comprising a compensator.

35. The device of claim 22 further comprising a first scanning mirror reflecting light on the first optical path and a second mirror reflecting light on the second optical path.

36. The device of claim 22 further comprising a beam splitter and a plurality of lenses.

37. The device of claim 22 further comprising an analog to digital converter connected to the detector.

38. The device of claim 22 further comprising a heterodyne detection system.

39. The device of claim 22 further comprising a fiber optic probe and an endoscope.

40. The device of claim 22 wherein the light source comprises a continuous wave laser.