Monopolar and bipolar current application for transdermal drug delivery and analyte extraction

• US 6,611,706 B2
• Filed: 05/17/2001
• Issued: 08/26/2003
• Est. Priority Date: 11/09/1998
• Status: Expired due to Term

• Current Assignee: Syneron Medical Limited (Syneron Incorporated)
• Original Assignee: TransPharma Ltd.
• Inventors: Avrahami, Zohar, Sohn, Zeʼev
• Primary Examiner(s): KENNEDY, SHARON E
• Application Number:
  US09/859,645
• Publication Number:
  US 20020058936A1
• Time in Patent Office: 831 Days
• Field of Search: 604/19-21, 607/2, 607/3, 607/152, 600/391, 600/372
• US Class Current: 604/20
• CPC Class Codes: A61B 18/14 Probes or electrodes therefor
• CPC Class Codes: A61B 2017/00765 Decreasing the barrier function of skin tissue by radiated energy, e.g. using ultrasound, using laser for skin perforation
• CPC Class Codes: A61B 2018/00452 Skin
• CPC Class Codes: A61B 2018/1213 creating an arc
• CPC Class Codes: A61M 37/0015 by using microneedles
• CPC Class Codes: A61N 1/30 Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
• CPC Class Codes: A61N 1/325 for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body electrodes for external use A61N1/0428
• CPC Class Codes: A61N 1/327 for enhancing the absorption properties of tissue, e.g. by electroporation

Abstract

A device for facilitating transdermal passage of a substance through skin on the body of a subject is provided. The device preferably includes afcn electrode and a control unit. In a preferred embodiment, the control unit is adapted to drive the electrode to apply to the skin a current capable of ablating stratum corneum epidermidis of the skin, so as to facilitate transdermal passage of the substance. The control unit detects generation of at least one spark responsive to application of the current, and modifies a parameter of the current responsive to detecting the generation of the at least one spark.

Claims

1. A device for facilitating passage of a substance through skin on the body of a subject, comprising:

an electrode, a first portion of which having a first cross-section, and a second portion of which having a second cross-section which is different from the first cross-section, the electrode being adapted to be placed such that the first portion is in contact with the skin; and

a control unit, adapted to drive the electrode to apply an electric current to the skin capable of ablating stratum corneum epidermidis thereof, so as to facilitate passage through the skin of the substance.

2. A device according to claim 1, wherein the control unit is adapted to detect a transition from (a) a first time, in which the second portion is substantially not in contact with the skin, to (b) a second time, in which the second portion is in contact with the skin.

3. A device according to claim 2, wherein the second portion is electrically conductive.

4. A device according to claim 1, wherein the second portion is substantially electrically non-conductive.

5. A device according to claim 1, wherein the second portion comprises a partially non-conductive material.

6. A device according to claim 1, wherein the second cross-section has a characteristic diameter larger than a characteristic diameter of the first cross-section.

7. A device according to claim 1, wherein the first portion is adapted for insertion into the skin responsive to ablation of the stratum corneum.

8. A device according to claim 2, wherein the control unit is adapted to modify a parameter of the current responsive to detecting the transition.

9. A device according to claim 1, wherein the second portion comprises the substance.

10. A device for facilitating passage of a substance through skin on the body of a subject, comprising:

a longitudinal electrode, comprising;

a first portion, having a first property at a first longitudinal site of the electrode, and

a second portion, having a second property at a second longitudinal site of the electrode, the second property being different from the first property, the electrode being adapted to be placed such that the first portion is in contact with the skin; and

a control unit, adapted to drive the electrode to apply an electric current to the skin capable of ablating stratum corneum epidermidis thereof.

11. A device according to claim 10, wherein the control unit is adapted to detect a transition from (a) a first time, in which the second portion is substantially not in contact with the skin, to (b) a second time, in which the second portion is in contact with the skin.

12. A device according to claim 10, wherein the second portion comprises a measured quantity of the substance.

13. A device according to claim 11, wherein the first portion has an electrical property, and wherein the second portion has an electrical property different from the electrical property of the first portion.

14. A device according to claim 11, wherein the first portion has a material property, and wherein the second portion has a material property different from the material property of the first portion.

15. A device according to claim 11, wherein the control unit is adapted to modify a parameter of the current responsive to detecting the transition.