Multi-site cardiac stimulation device and method for detecting retrograde conduction

• US 6,611,714 B1
• Filed: 06/13/2001
• Issued: 08/26/2003
• Est. Priority Date: 06/13/2001
• Status: Expired due to Term

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories)
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories)
• Inventors: Mo, Anthony
• Primary Examiner(s): Evanisko, George R.
• Assistant Examiner(s): KHAN, OMAR A
• Application Number:
  US09/881,449
• Time in Patent Office: 804 Days
• Field of Search: 607/27, 600/515
• US Class Current: 607/27
• CPC Class Codes: A61N 1/3622 comprising two or more electrodes co-operating with different heart regions
• CPC Class Codes: A61N 1/3684 for stimulating the heart at multiple sites of the ventricle or the atrium
• CPC Class Codes: A61N 1/36842 Multi-site stimulation in the same chamber
• CPC Class Codes: A61N 1/36843 Bi-ventricular stimulation

Abstract

An implantable cardiac stimulation device, such as a pacemaker, defibrillator and/or cardioverter, and an associated method that provide cardiac stimulation to at least two ventricular stimulation sites, within a single ventricle or across two ventricles. A high intrinsic atrial rate triggers a retrograde conduction detection routine when a high ventricular stimulation rate is sustained for a predetermined number of cycles during an atrial sensing mode. This routine interrupts concurrent stimulation, and alternates the stimulation output to the different ventricular sites.

Claims

1. A method of detecting retrograde conduction from a ventricular stimulation site to avoid pacemaker-mediated tachycardia during substantially concurrent, multi-site ventricular stimulation, the method comprising:

determining that a high ventricular stimulation rate is sustained for a predetermined number of cycles during an atrial sensing mode;

identifying two or more ventricular stimulation sites associated with a retrograde conduction pathway;

temporarily interrupting substantially concurrent stimulations to the two or more ventricular stimulation sites; and

alternating stimulation to the two or more ventricular stimulation sites.

2. The method of claim 1, wherein the step of triggering the retrograde conduction detection routine includes adjusting intervals between a sensed P-wave and the stimulation delivered to the two or more ventricular stimulation sites.

3. The method of claim 2, wherein the step of adjusting the intervals includes adjusting a first interval (PV₁ interval) between a sensed P-wave and a stimulation of a first ventricular stimulation site.

4. The method of claim 3, wherein the step of adjusting the intervals includes adjusting an interval (PV₂ interval) between a sensed P-wave and a stimulation of a second ventricular stimulation site;

and

wherein the first and second intervals are different.

5. The method of claim 2, wherein the step of adjusting the intervals includes adjusting a second interval (PV₂ interval) between a sensed P-wave and a stimulation of a second ventricular stimulation site.

6. The method of claim 2, wherein the step of adjusting the intervals includes adjusting programmable intervals (PV intervals) between a sensed P-wave and stimulation pulses to the two or more ventricular stimulation sites.

7. The method of claim 6, wherein, following the step of adjusting the PV intervals delivering ventricular stimulation to only one ventricular stimulation site per cardiac cycle so that the two or more ventricular stimulation sites are stimulated in an alternating fashion at respective adjusted PV intervals for a predetermined number of cardiac cycles.

8. The method of claim 7, further including the step of measuring an interval (VP interval) from ventricular stimulation pulses delivered to the two or more ventricular stimulation sites, to a subsequently sensed P-wave, during alternating ventricular stimulation delivery.

9. The method of claim 8, wherein the step of identifying two or more ventricular stimulation sites associated with the retrograde conduction pathway includes determining if two or more retrograde conduction pathways exist.

10. The method of claim 9, wherein the step of determining if two or more retrograde conduction pathways exist, includes, for each of the two or more ventricular stimulation sites, the step of measuring a mean interval (mean VP interval) from the ventricular stimulation pulse to a subsequently sensed P-wave.

11. The method of claim 10, further including the step of calculating a standard deviation of the mean interval (VP interval) for each of the two or more ventricular stimulation sites.

12. The method of claim 11, further including the step of comparing the standard deviation of the mean interval for each of the two or more ventricular stimulation sites to a minimum acceptable value.

13. The method of claim 12, wherein if the standard deviation associated with a ventricular stimulation site is less than the minimum acceptable value, a retrograde conduction pathway is detected for the associated ventricular stimulation site.

14. The method of claim 13, wherein if retrograde conduction is detected for two or more ventricular stimulation sites, confirming retrograde conduction by a mathematical relationship between a change in an atrial rate and a change in the interval (VP interval) from the ventricular stimulation pulse delivered to the associated ventricular simulation site.

15. The method of claim 14, wherein the step of confirming retrograde conduction includes the step of confirming retrograde conduction for two or more pathways.

16. The method of claim 15, wherein upon confirming retrograde conduction for two or more pathways, automatically adjusting an operating parameter.

17. The method of claim 16, wherein automatically adjusting the operating parameter includes extending a post-ventricular atrial blanking period.

18. The method of claim 16, automatically adjusting the operating parameter includes extending a post ventricular atrial refractory period to be longer than a longest retrograde conduction time, to terminate pacemaker-mediated tachycardia by preventing atrial sensing of a retrograde P-wave.

19. The method of claim 15, wherein upon confirming retrograde conduction for two or more pathways, automatically adjusting stimulation parameters so that a pacemaker-mediated tachycardia is terminated.

20. The method of claim 1, wherein the step of alternating stimulation to the two or more ventricular stimulation sites includes delivering stimulation to only one ventricular stimulation site per cardiac cycle.

21. A cardiac stimulation device for detecting retrograde conduction from a ventricular stimulation site to avoid pacemaker-mediated tachycardia during substantially concurrent, multi-site ventricular stimulation, comprising:

an atrial sensor that senses atrial events;

a pulse generator that generates stimulation pulses to be delivered to the ventricles;

a control circuit, connected to the atrial sensor and pulse generator, that controls the pulse generator to generate stimulation pulses at a rate based on the sensed atrial events, and that causes a high intrinsic atrial rate to trigger a retrograde conduction detection routine when a high ventricular stimulation rate is sustained for a predetermined number of cycles during an atrial sensing mode;

a ventricular sensor that identifies two or more ventricular stimulation sites associated with a retrograde conduction pathway; and

wherein the control circuit temporarily interrupts substantially concurrent stimulations to the two or more ventricular stimulation sites, and alternates the stimulation of the two or more ventricular stimulation sites.

22. The cardiac stimulation device of claim 21, wherein the retrograde conduction detection routine is operative to adjust an interval between a sensed atrial event and the stimulation delivered to the two or more ventricular stimulation sites.

23. The cardiac stimulation device of claim 22, wherein the intervals between the sensed P-wave and the stimulation delivered to the two or more ventricular stimulation sites, include an adjusted first interval (PV₁ interval) between a sensed P-wave and a stimulation of a first ventricular stimulation site.

24. The cardiac stimulation device of claim 23, wherein the intervals between the sensed P-wave and the stimulation delivered to the two or more ventricular stimulation sites, include an adjusted interval (PV₂ interval) between a sensed P-wave and stimulation of a second ventricular stimulation site;

and

wherein the first and second intervals are distinct.

25. The cardiac stimulation device of claim 22, wherein the intervals between the sensed P-wave and the stimulation delivered to the two or more ventricular stimulation sites, include a second adjusted interval (PV₂ interval) between a sensed P-wave and a stimulation of a second ventricular stimulation site.

26. The cardiac stimulation device of claim 22, wherein the intervals between the sensed P-wave and the stimulation delivered to the two or more ventricular stimulation sites, include adjustable intervals (PV intervals) between a sensed P-wave and stimulation pulses to the two or more ventricular stimulation sites.

27. The cardiac stimulation device of claim 26, wherein the control circuit alternates stimulation to the two or more ventricular stimulation sites by delivering stimulation to only one ventricular stimulation site per cardiac cycle, so that the two or more ventricular stimulation sites are stimulated in an alternating fashion at respective adjusted PV intervals for a predetermined number of cardiac cycles.

28. The cardiac stimulation device of claim 27, wherein the control circuit further measures an interval (VP interval) from ventricular stimulation pulses delivered to the two or more ventricular stimulation sites, to a subsequently sensed P-wave, during alternating ventricular stimulation delivery.

29. The cardiac stimulation device of claim 28, wherein the ventricular sensor identifies two or more ventricular stimulation sites associated with the retrograde conduction pathway by determining if two or more retrograde conduction pathways exist.

30. The cardiac stimulation device of claim 21, wherein the control circuit alternates stimulation to the two or more ventricular stimulation sites by delivering stimulation to only one ventricular stimulation site per cardiac cycle.

31. A cardiac stimulation device for detecting retrograde conduction from a ventricular stimulation site to avoid pacemaker-mediated tachycardia during multi-site ventricular stimulation, comprising:

means for stimulating the ventricles;

means for triggering a retrograde conduction detection routine when a high ventricular stimulation rate is sustained for a predetermined number of cycles during an atrial sensing mode;

means for identifying two or more ventricular stimulation sites associated with a retrograde conduction pathway; and

wherein the triggering means temporarily interrupts substantially concurrent stimulations to the two or more ventricular stimulation sites, and alternates the stimulation of the two or more ventricular stimulation sites.

32. The cardiac stimulation device of claim 31, wherein the retrograde conduction detection routine is operative to adjust an interval between a sensed atrial event and the stimulation delivered to the two or more ventricular stimulation sites.

33. The cardiac stimulation device of claim 32, wherein the intervals between the sensed P-wave and the stimulation delivered to the two or more ventricular stimulation sites, include an adjusted first interval (PV₁ interval) between a sensed P-wave and a stimulation of a first ventricular stimulation site.

34. The cardiac stimulation device of claim 33, wherein the intervals between the sensed P-wave and the stimulation delivered to the two or more ventricular stimulation sites, include an adjusted interval (PV₂ interval) between a sensed P-wave and stimulation of a second ventricular stimulation site;

and

wherein the first and second intervals are distinct.

35. The cardiac stimulation device of claim 32, wherein the intervals between the sensed P-wave and the stimulation delivered to the two or more ventricular stimulation sites, include a second adjusted interval (PV₂ interval) between a sensed P-wave and a stimulation of a second ventricular stimulation site.

36. The cardiac stimulation device of claim 32, wherein the intervals between the sensed P-wave and the stimulation delivered to the two or more ventricular stimulation sites, include adjustable intervals (PV intervals) between a sensed P-wave and stimulation pulses to the two or more ventricular stimulation sites.

37. The cardiac stimulation device of claim 36, wherein the triggering means alternates stimulation to the two or more ventricular stimulation sites by delivering stimulation to only one ventricular stimulation site per cardiac cycle, so that the two or more ventricular stimulation sites are stimulated in an alternating fashion at respective adjusted PV intervals for a predetermined number of cardiac cycles.

38. The cardiac stimulation device of claim 37, wherein the triggering means further measures an interval (VP interval) from ventricular stimulation pulses delivered to the two or more ventricular stimulation sites, to a subsequently sensed P-wave, during alternating ventricular stimulation delivery.

39. The cardiac stimulation device of claim 38, wherein the ventricular sensor identifies two or more ventricular stimulation sites associated with the retrograde conduction pathway by determining if two or more retrograde conduction pathways exist.

40. The cardiac stimulation device of claim 31, wherein the triggering means alternates stimulation to the two or more ventricular stimulation sites by delivering stimulation to only one ventricular stimulation site per cardiac cycle.