Software for the display of chromatographic separation data

• US 6,611,768 B2
• Filed: 05/24/2002
• Issued: 08/26/2003
• Est. Priority Date: 12/30/1997
• Status: Expired due to Term

• Current Assignee: Caliper Life Sciences Incorporated (Revvity, Inc.)
• Original Assignee: Caliper Holdings Incorporated
• Inventors: Gallagher, Steven J.
• Primary Examiner(s): SHAH, KAMINI S
• Application Number:
  US10/155,324
• Publication Number:
  US 20020138209A1
• Time in Patent Office: 459 Days
• Field of Search: 702/22, 210/198.2, 250/461.2, 356/344
• US Class Current: 702/22
• CPC Class Codes: G01N 2030/625 by measuring reference material, e.g. carrier without sample
• CPC Class Codes: G01N 27/44717 Arrangements for investigating the separated zones, e.g. localising zones
• CPC Class Codes: G01N 30/86 Signal analysis
• CPC Class Codes: G01N 30/8651 Recording, data aquisition, archiving and storage

Abstract

Techniques for displaying chromatographic data using a graphical user interface are provided. Chromatographic separation data that is a series of measurements for a sample at a scanning location over time can be displayed on a display device in a series of bands. Additionally, the series of bands for multiple samples can be aligned on the display device.

Claims

1. A computer implemented method of displaying chromatographic separation data, comprising:

receiving a series of measurements indicating presence of constituents in a sample at a scanning location over time; and

displaying the series of measurements for the sample as a series of bands, the bands being arranged to resemble output from an electrophoresis gel.

2. The method of claim 1, further comprising displaying the series of measurements for the sample as a graph of measurements vs. time.

3. The method of claim 1, wherein the sample includes at least one marker and the series of measurements for the sample indicates presence of the at least one marker in the sample at a scanning location over time.

4. The method of claim 3, further comprising:

identifying at least one peak in the series of measurements for the sample that corresponds to the at least one marker; and

aligning the series of measurements for the sample so that any displayed bands that correspond to the at least one marker are aligned with a predetermined location.

5. The method of claim 3, further comprising:

identifying two peaks in the series of measurements for the sample that correspond to two markers; and

scaling the series of measurements for the sample so that the two displayed bands that correspond to the two markers are aligned with predetermined locations.

20. The method of claim 1 wherein at least one of the series of bands is distinguishable from other bands in the series of bands.

21. The method of claim 1 wherein the bands are aligned.

22. The method of claim 1 further including:

generating the series of bands using a modifiable criterion.

23. The method of claim 1 wherein the separation data is obtained from an experiment carried out on a microfluidic device.

6. A computer implemented method of displaying chromatographic separation data, comprising:

receiving a series of measurements indicating presence of constituents in a sample at a scanning location over time, wherein the sample includes at least one marker and the series of measurements for the sample indicates presence of the at least one marker in the sample at a scanning location over time;

displaying the series of measurements for the sample as a series of bands; and

displaying bands that correspond to the constituents in the sample visually different than bands that correspond to the at least one marker.

7. A computer implemented method of displaying chromatographic separation data, comprising:

receiving a series of measurements indicating presence of constituents in a sample at a scanning location over time, wherein the sample includes at least one marker and the series of measurements for the sample indicates presence of the at least one marker in the sample at a scanning location over time;

displaying the series of measurements for the sample as a series of bands;

receiving input to invert the display of the series of bands; and

inverting the displayed series of bands.

8. A computer system, comprising:

a processor;

a display device coupled to the processor;

a computer readable medium coupled to the processor that stores a computer program that displays chromatographic separation data, the computer program including;

computer code that receives a series of measurements indicating presence of constituents in a sample at a scanning location over time; and

computer code that displays the series of measurements for the sample as a series of bands on the display device, the bands being arranged to resemble output from an electrophoresis gel.

24. The computer program product of claim 8 wherein at least one of the series of bands is distinguishable from other bands in the series of bands.

25. The computer program product of claim 8 wherein the bands are aligned.

26. The computer program product of claim 8 further including:

generating the series of bands using a modifiable criterion.

27. The computer program product of claim 8 wherein the separation data is obtained from an experiment carried out on a microfluidic device.

9. A computer program product that displays chromatographic separation data, comprising:

computer code that receives a series of measurements indicating presence of constituents in a sample at a scanning location over time;

computer code that displays the series of measurements for the sample as a series of bands, the bands being arranged to resemble output from an electrophoresis gel; and

a computer readable medium that stores the computer codes.

10. The computer program product of claim 9, wherein the computer readable medium is selected from the group consisting of CD-ROM, floppy disk, tape, flash memory, system memory, hard drive, and data signal embodied in a carrier wave.

11. A computer system, comprising:

a processor;

a display device coupled to the processor;

a computer readable medium coupled to the processor that stores a computer program that displays chromatographic separation data, the computer program including;

computer code that receives a series of measurements indicating presence of constituents in a sample at a scanning location over time, wherein the sample includes at least one marker and the series of measurements for the sample indicates presence of the at least one marker in the sample at a scanning location over time;

computer code that displays the series of measurements for the sample as a series of bands;

computer code that displays the series of measurements for the sample as a graph of measurements vs. time; and

computer code that displays bands that correspond to the constituents in the sample visually different than bands that correspond to the at least one marker.

12. A computer program product that displays chromatographic separation data, comprising:

computer code that receives a series of measurements indicating presence of constituents in a sample at a scanning location over time, wherein the sample includes at least one marker and the series of measurements for the sample indicates presence of the at least one marker in the sample at a scanning location over time;

computer code that displays the series of measurements for the sample as a series of bands;

computer code that displays the series of measurements for the sample as a graph of measurements vs. time;

computer code that displays bands that correspond to the constituents in the sample visually different than bands that correspond to the at least one marker; and

a computer readable medium that stores the computer codes.

13. The computer program product of claim 12, wherein the computer readable medium is selected from the group consisting of CD-ROM, floppy disk, tape, flash memory, system memory, hard drive, and data signal embodied in a carrier wave.

14. A computer system, comprising:

a processor;

a display device coupled to the processor;

a computer readable medium coupled to the processor that stores a computer program that displays chromatographic separation data, the computer program including;

computer code that receives a series of measurements indicating presence of constituents in a sample at a scanning location over time, wherein the sample includes at least one marker and the series of measurements for the sample indicates presence of the at least one marker in the sample at a scanning location over time;

computer code that displays the series of measurements for the sample as a series of bands;

computer code that displays the series of measurements for the sample as a graph of measurements vs. time;

computer code that receives input to invert the display of the series of bands; and

computer code that inverts the displayed series of bands.

15. A computer program product that displays chromatographic separation data, comprising:

computer code that receives a series of measurements indicating presence of constituents in a sample at a scanning location over time, wherein the sample includes at least one marker and the series of measurements for the sample indicates presence of the at least one marker in the sample at a scanning location over time;

computer code that displays the series of measurements for the sample as a series of bands;

computer code that displays the series of measurements for the sample as a graph of measurements vs. time;

computer code that receives input to invert the display of the series of bands;

computer code that inverts the displayed series of bands; and

a computer readable medium that stores the computer codes.

16. The computer program product of claim 15, wherein the computer readable medium is selected from the group consisting of CD-ROM, floppy disk, tape, flash memory, system memory, hard drive, and data signal embodied in a carrier wave.

17. A computer implemented method of displaying chromatographic separation data, comprising:

receiving a series of measurements indicating presence of constituents in a sample at a scanning location over time, wherein the sample includes at least one marker and the series of measurements for the sample indicates presence of the at least one marker in the sample at a scanning location over time; and

displaying the series of measurements for the sample as a series of bands.

18. The method of claim 17, further comprising:

identifying at least one peak in the series of measurements for the sample that corresponds to the at least one marker; and

aligning the series of measurements for the sample so that any displayed bands that correspond to the at least one marker are aligned with a predetermined location.

19. The method of claim 17, further comprising:

identifying two peaks in the series of measurements for the sample that correspond to two markers; and

scaling the series of measurements for the sample so that the two displayed bands that correspond to the two markers are aligned with predetermined locations.