Systems and methods for creating longer necrosed volumes using a phased array focused ultrasound system

• US 6,613,004 B1
• Filed: 04/21/2000
• Issued: 09/02/2003
• Est. Priority Date: 04/21/2000
• Status: Expired due to Term

• Current Assignee: InSightec Ltd.
• Original Assignee: Insightec Txsonics Ltd.
• Inventors: Vitek, Shuki, Maor, Dov
• Primary Examiner(s): Smith, Ruth S.
• Application Number:
  US09/557,078
• Time in Patent Office: 1,229 Days
• Field of Search: 601/2, 601/3, 601/4, 600/439, 600/459, 367/138
• US Class Current: 601/2
• CPC Class Codes: A61B 17/22004 using mechanical vibrations, e.g. ultrasonic shock waves A61B17/225 takes precedence
• CPC Class Codes: A61N 2007/0065 Concave transducers
• CPC Class Codes: A61N 2007/0078 with multiple treatment transducers
• CPC Class Codes: A61N 7/02 Localised ultrasound hyperthermia hyperthermia in general A61F7/00
• CPC Class Codes: G10K 11/346 using phase variation

Abstract

A system for performing a therapeutic procedure using focused ultrasound includes a transducer array including a plurality of transducer elements, drive circuitry coupled to the transducer elements, and a controller coupled to the drive circuitry. The controller controls the drive circuitry to alternatively provide sets of the transducer elements with respective drive signals. Each of the sets of transducer elements are alternatively driven with the respective drive signals for a predetermined duration during a sonication, while substantially continuously focusing ultrasonic energy produced by the transducer elements of each set at a desired focal zone. The controller also controls a phase component of the respective drive signals to provide a predetermined size, shape, and/or location of the focal zone, and thereby necrose a target tissue region at the focal zone.

Claims

1. A system for performing a therapeutic procedure in a target tissue region of a patient using focused ultrasound, comprising:

a transducer array comprising a plurality of “

n”

transducer elements;

drive circuitry coupled to the transducer elements, the drive circuitry configured for providing sets of respective drive signals to each of the transducer elements; and

a controller coupled to the drive circuitry, the controller configured for alternatively focusing ultrasonic energy from a plurality of sets of the transducer elements at a target tissue region within a patient being treated during a single sonication, each set of transducer elements including a plurality of “

m”

transducer elements, with “

m”

being less than “

n,”

wherein the controller is further configured for dividing the transducer array into “

p”

sets of transducer elements during the single sonication, “

p”

being greater than one, each of the “

p”

sets of transducer elements including “

n/p”

transducer elements.

2. The system of claim 1 wherein the transducer elements comprise a plurality of concentric rings, and wherein the sets of transducer elements comprise first and second sets of the concentric rings.

3. The system of claim 2, wherein each of the concentric rings is divided circumferentially into a plurality of curved elements.

4. The system of claim 3, wherein the controller is further configured for controlling at least one of delay and amplitude of respective drive signals provided to the curved elements to provide a predetermined size and shape of a focal zone created by the transducer elements.

5. The system of claim 1, wherein the controller is further configured for controlling at least one of delay and amplitude of the respective drive signals to focus the transducer elements in each of the plurality of sets substantially at a desired focal zone.

6. A system for performing a therapeutic procedure in a target tissue region of a patient using focused ultrasound, comprising:

a transducer array comprising a plurality of “

n”

transducer elements;

drive circuitry coupled to the transducer elements, the drive circuitry configured for providing sets of respective drive signals to each of the transducer elements; and

a controller coupled to the drive circuitry, the controller configured for alternatively focusing ultrasonic energy from a plurality of sets of the transducer elements at a target tissue region within a patient being treated during a single sonication, each set of transducer elements including a plurality of “

m”

transducer elements, with “

m”

being less than “

n,”

wherein the controller is further configured for dividing the transducer array into “

p”

sets of transducer elements during the single sonication, “

p”

being greater than one, each set of transducer elements having an overall surface area “

a,”

where “

a”

equals “

A/p,”

A being an aperture area of the entire transducer array, such that an f-number of each set is substantially greater than an f-number of the entire transducer array the f-number being a ratio of a radius of curvature of the transducer array to a cross-sectional dimension of the transducer array.

7. A method for performing a therapeutic procedure in a target tissue region of a patient using focused ultrasound, the method comprising:

providing a transducer array comprising a plurality of sets of transducer elements, the plurality of gets including all of the transducer elements of the transducer array; and

alternatively driving each of the sets of transducer elements with a set of respective drive signals for a predetermined duration during a single sonication, while substantially continuously focusing ultrasonic energy produced by the transducer elements of each set at a desired focal zone,

wherein the predetermined duration for which each set of transducer elements is alternatively driven is not more than about one second.

8. The method of claim 7, wherein the sonication has a duration of at least about five seconds.

9. The method of claim 7, wherein the step of alternatively driving each of the sets of transducer elements comprises alternatively coupling each of the sets of transducer elements to drive circuitry that provides the respective drive signals.

10. The method of claim 7, wherein each of the sets of transducer elements has an overall surface area that is substantially the same as one another such that the ultrasonic energy produced by each set is substantially the same as one another.

11. The method of claims 7, wherein the transducer array includes a plurality of “

n”

transducer elements, and wherein the method further comprises selecting a plurality of “

m”

transducer elements to include in each of the sets before each of the sets is alternatively driven, “

m”

being less than “

n.”

12. The method of claim 7, further comprising randomly assigning a plurality of the transducer elements to each of the sets of transducer elements before each of the sets are alternatively driven.

13. A system for performing a therapeutic procedure in a target tissue region of a patient using focused ultrasound, comprising:

a transducer having a surface area “

A” and

an f-number, the transducer being configured for emitting ultrasonic energy towards a focal zone, the f-number being a ratio of a radius of curvature of the transducer to a cross-sectional dimension of the transducer;

drive circuitry coupled to the transducer, the drive circuitry configured for providing drive signals to the transducer to cause the transducer to emit ultrasonic energy; and

a shutter device disposed between the transducer and the focal zone, the shutter device being configured for exposing the focal zone to alternative surface areas “

a”

of the transducer, “

a”

being less than “

A.”

14. The system of claim 13, wherein the transducer comprises a plurality of “

n”

transducer elements.

15. The system of claim 14, further comprising a controller coupled to the drive circuitry, the controller configured for controlling the drive circuitry to alternatively provide sets of transducer elements with respective drive signals, each set of transducer elements including a plurality of “

m”

transducer elements, with “

m”

being less than “

n.”

16. The system of claim 13, wherein the shutter device comprises a plurality of shutters.

17. The system of claim 16, further comprising a controller for selectively opening one or more of the plurality of shutters to expose the focal zone to alternative surface areas “

a”

of the transducer.

18. The system of claim 13, wherein the shutter device comprises an opening therethrough having a cross-sectional area “

a”

, and wherein the shutter device is movable to expose the focal zone to alternative surface areas of the transducer through the opening.

19. A method for performing a therapeutic procedure in a target tissue region of a patient using focused ultrasound, the method comprising:

providing a transducer configured for emitting ultrasonic energy having a surface area “

A;

”

driving the transducer with drive signals for a predetermined duration during a single sonication, while substantially focusing ultrasonic energy produced by the transducer at the target tissue region; and

alternatively directing ultrasonic energy from a plurality of surface areas “

a”

of the transducer, “

a”

being less than “

A,”

during the single sonication while substantially focusing the ultrasonic energy at the target tissue region.

20. The method of claim 19, wherein the transducer comprises a plurality of “

n”

transducer elements, and wherein the step of directing ultrasonic energy comprises alternatively driving a plurality of “

m”

transducer elements with the drive signals, wherein “

m”

is less than “

n”

.

21. The method of claim 19, wherein the surface area “

a”

is periodically changed during the sonication.

22. A method for performing a therapeutic procedure in a target tissue region of a patient using focused ultrasound, the method comprising:

providing a transducer configured for emitting ultrasonic energy having a surface area “

A;

”

driving the transducer with drive signals for a predetermined duration during a sonication, while substantially focusing ultrasonic energy produced by the transducer at the target tissue region; and

alternatively directing ultrasonic energy from surface areas “

a”

of the transducer, “

a”

being less than “

A,”

during the sonication towards the target tissue region;

wherein a shutter device is disposed between the transducer and the patient, and wherein the step of alternatively directing ultrasonic energy comprises controlling the shutter device to expose at the patient to surface areas “

a”

of the transducer through the shutter device.

23. The method of claim 22, wherein the step of controlling the shutter device comprises selectively opening one or more shutters on the shutter device to expose the patient to a surface area “

a”

of the transducer aligned with the open shutters.

24. The method of claim 22, wherein the shutter device comprises one or more openings therethrough having a total cross-sectional area “

a,” and

wherein the step of controlling the shutter device comprises moving the one or more openings to expose the patient to surface areas “

a”

aligned with the one or more openings.