Systems and methods for steering a focused ultrasound array

• US 6,613,005 B1
• Filed: 11/28/2000
• Issued: 09/02/2003
• Est. Priority Date: 11/28/2000
• Status: Active Grant

• Current Assignee: InSightec Ltd.
• Original Assignee: Insightec Txsonics Ltd.
• Inventors: Maor, Dov, Friedman, Zvi
• Primary Examiner(s): Walberg, Teresa
• Assistant Examiner(s): FUQUA, SHAWNTINA T
• Application Number:
  US09/724,716
• Time in Patent Office: 1,008 Days
• Field of Search: 601/2, 600/407, 600/411, 600/427, 600/371, 600/437, 600/431, 600/443, 600/459, 600/462, 600/463, 600/467
• US Class Current: 601/2
• CPC Class Codes: A61N 2007/006 Lenses
• CPC Class Codes: A61N 2007/0065 Concave transducers
• CPC Class Codes: A61N 2007/0078 with multiple treatment transducers
• CPC Class Codes: A61N 2007/0091 with moving parts, e.g. transducers, lenses, reflectors
• CPC Class Codes: A61N 2007/0095 by modifying an excitation signal
• CPC Class Codes: A61N 7/02 Localised ultrasound hyperthermia hyperthermia in general A61F7/00

Abstract

A focused ultrasound system includes a transducer array including a plurality of sub-arrays, each sub-array defining an acoustic emission surface and including a plurality of transducer elements thereon. A mechanical controller is coupled to the sub-arrays that includes actuators for moving the sub-arrays to adjust an orientation of the acoustic emission surfaces of respective sub-arrays to facilitate steering of acoustic energy emitted by the transducer elements towards a target tissue region. Drive circuitry provides drive signals to the transducer elements, whereby the transducer elements emit acoustic energy from their respective acoustic emission surfaces to ablate the target region, such as a tumor within a patient'"'"'s brain.

Claims

1. A system for performing a therapeutic procedure in a target region of a patient using focused ultrasound, comprising:

a transducer array comprising a plurality of sub-arrays, each sub-array defining an acoustic emission surface and including one or more transducer elements configured for emitting acoustic energy from the acoustic emission surface, each sub-array being independently movable with respect to one another about at least two respective axes of rotation;

drive circuitry coupled to the transducer elements, the drive circuitry configured for providing respective drive signals to the transducer elements, whereby the transducer elements may emit acoustic energy from their respective acoustic emission surfaces; and

a mechanical controller coupled to the sub-arrays and configured for moving the sub-arrays about the at least two respective axes of rotation to adjust an orientation of the acoustic emission surfaces of respective sub-arrays to facilitate focusing of the acoustic energy emitted by the transducer elements towards the target region.

2. The system of claim 1, wherein the transducer array comprises a support structure, the sub-arrays being attached to the support structure.

3. The system of claim 2, wherein the support structure has a generally concave shape.

4. The system of claim 2, wherein the sub-arrays are pivotably fixed to the support structure.

5. The system of claim 4, wherein the mechanical controller comprises an actuator coupled to each of the sub-arrays for mechanically pivoting the respective sub-array to adjust its orientation.

6. The system of claim 5, wherein the mechanical controller comprises a pair of actuators coupled to each sub-array, the pair of actuators configured for pivoting the respective sub-array in substantially orthogonal directions.

7. The system of claim 5, wherein the actuator comprises a piezoelectric actuator.

8. The system of claim 1, wherein each sub-array includes a gimbal apparatus pivotably fixing the sub-arrays with respect to one another.

9. The system of claim 1, further comprising an electrical controller coupled to the drive circuitry, the electrical controller configured for controlling phase shift values of the respective drive signals to further focus the acoustic energy emitted by the transducer elements towards the target region.

11. The system of claim 1, wherein the transducer array is mounted within a fluid-filled casing.

12. The system of claim 11, wherein the casing has a substantially concave inner contact surface configured for substantially engaging a head of a patient.

13. The system of claim 12, wherein the sub-arrays are arranged within the casing such that the acoustic emission surfaces of the sub-arrays are generally oriented towards the inner contact surface.

10. A system for performing a therapeutic procedure in a target region of a patient using focused ultrasound, comprising:

a transducer array comprising a plurality of sub-arrays, each sub-array defining an acoustic emission surface and including one or more transducer elements configured for emitting acoustic energy from the acoustic emission surface, each sub-array being independently movable with respect to one another;

drive circuitry coupled to the transducer elements, the drive circuitry configured for providing respective drive signals to the transducer elements, whereby the transducer elements may emit acoustic energy from their respective acoustic emission surfaces;

a mechanical controller coupled to the sub-arrays and configured for moving the sub-arrays to adjust an orientation of the acoustic emission surfaces of respective sub-arrays to facilitate focusing of the acoustic energy emitted by the transducer elements towards the target region; and

an electrical controller coupled to the drive circuitry, the electrical controller configured for controlling phase shift values of the respective drive signals to further focus the acoustic energy emitted by the transducer elements towards the target region, wherein the electrical controller is configured for controlling the phase shift values of the drive signals to the transducer elements of a respective sub-array for compensating for aberrations in intervening tissue between the transducer and the target tissue.

14. A method for performing a therapeutic procedure in a target tissue region of a patient using focused ultrasound, the method comprising:

providing a transducer array comprising a plurality of sub-arrays, each sub-array including one or more transducer elements, each sub-array being independently movable relative to one another about two respective axes of rotation for adjusting an orientation of the sub-arrays with respect to one another;

driving the transducer elements with respective drive signals such that the transducer elements emit acoustic energy towards a target region; and

moving the sub-arrays with respect to one another about the two respective axes of rotation to focus the acoustic energy generated by the transducer elements towards the target region.

15. The method of claim 14, wherein the sub-arrays comprise an acoustic emission surface from which the transducer elements emit the acoustic energy, and wherein the step of moving the sub-arrays comprises pivoting the sub-arrays about a fixed point to adjust an angular orientation of their respective acoustic emission surfaces.

16. The method of claim 15, wherein the step of pivoting the sub-arrays comprises pivoting the sub-arrays about two respective axes of rotation that are substantially perpendicular to one another.

17. The method of claim 14, wherein the transducer array is acoustically coupled to a skull such that the target region is a tissue structure within the skull.

19. The method of claim 14, wherein the transducer elements are driven with respective drive signals such that the acoustic energy emitted by the transducer element substantially ablates the tissue structure.

20. The method of claim 14, wherein the transducer elements are driven with respective drive signals, and wherein phase shift values of drive signals driving the transducer elements of each sub-array is controlled such that the acoustic energy emitted by the respective sub-array is focused at a predetermined focal distance or is focused at a focal zone having a predetermined shape.

18. A method for performing a therapeutic procedure in a target tissue region of a patient using focused ultrasound, the method comprising:

providing a transducer array comprising a plurality of sub-arrays, each sub-array including one or more transducer elements, each sub-array being movable relative to one another for adjusting an orientation of the sub-arrays with respect to one another, the transducer array being acoustically coupled to a skull such that the target region is a tissue structure within the skull;

driving the transducer elements with respective drive signals such that the transducer elements emit acoustic energy towards a target region; and

moving the sub-arrays with respect to one another to focus the acoustic energy generated by the transducer elements towards the target region;

wherein the step of driving the transducer elements comprises controlling relative phase shift values of the respective drive signals to compensate for skull phase aberrations.

21. A system for performing a therapeutic procedure in a target region of a patient using focused ultrasound, comprising:

a transducer array comprising a plurality of sub-arrays, each sub-array defining an acoustic emission surface and including a plurality of transducer elements configured for emitting acoustic energy from the acoustic emission surface, each sub-array being independently movable with respect to one another;

drive circuitry coupled to the transducer elements, the drive circuitry configured for providing respective drive signals to the transducer elements, whereby the transducer elements may emit acoustic energy from their respective acoustic emission surfaces; and

a mechanical controller coupled to the sub-arrays and configured for moving the sub-arrays to adjust an orientation of the acoustic emission surfaces of respective sub-arrays to facilitate focusing of the acoustic energy emitted by the transducer elements towards the target region.

22. The system of claim 21, wherein each sub-array is pivotable about two respective axes of rotation.

23. The system of claim 22, wherein the two respective axes of rotation that are substantially perpendicular to one another.