Platelet suspensions and methods for resuspending platelets

• US 6,613,566 B2
• Filed: 10/26/2001
• Issued: 09/02/2003
• Est. Priority Date: 06/09/1997
• Status: Expired due to Term

• Current Assignee: Fenwal Incorporated (Fresenius SE & Co. KGaA)
• Original Assignee: Baxter International Inc.
• Inventors: Farrell, Liam C., Kandler, Richard L.
• Primary Examiner(s): Weber, Jon P.
• Application Number:
  US10/029,785
• Publication Number:
  US 20020110914A1
• Time in Patent Office: 676 Days
• Field of Search: 435/2, 435/372
• US Class Current: 435/372
• CPC Class Codes: A01N 1/02 Preservation of living parts
• CPC Class Codes: A01N 1/0205 Chemical aspects
• CPC Class Codes: A01N 1/0226 Physiologically active agents, i.e. substances affecting physiological processes of cells and tissue to be preserved, e.g. anti-oxidants or nutrients
• CPC Class Codes: A61P 7/00 Drugs for disorders of the blood or the extracellular fluid

Abstract

Platelet suspensions and methods for resuspending platelet concentrates are disclosed. The platelet concentrates are resuspended by combining a platelet concentrate with a substance capable of resuspending platelets, such as a salt solution. The resuspended platelets may be stored and/or administered to a patient.

Claims

1. A method for providing a suspension of blood platelets suitable for transfusion to a patient, said method comprising:

providing a volume of concentrated blood platelets;

suspending said platelets in a chloride solution; and

adding plasma to said suspended platelets.

2. The method of claim 1 wherein said chloride solution is selected from the group consisting of 0.9% sodium chloride and 0.9% potassium chloride.

3. The method of claim 1 comprising suspending said platelets in a hypertonic chloride solution.

4. The method of claim 3 wherein said hypertonic chloride solution is selected from the group consisting of hypertonic sodium chloride and hypertonic potassium chloride.

5. The method of claim 4 wherein said chloride solution comprises 1.8% sodium chloride.

6. The method of claim 4 wherein said chloride solution comprises 1.12% potassium chloride.

7. The method of claim 1 wherein the volume of said concentrated blood platelets is approximately 5-35 ml and the volume of said solution is between approximately 20-40 ml.

8. The method of claim 1 further comprising agitating said platelets and said chloride solution while suspending.

9. The method of claim 1 comprising adding a platelet storage medium with said plasma to said suspended platelets.

10. The method of claim 1 wherein said chloride solution comprises sodium chloride, diabasic sodium phosphate, monobasic sodium phosphate, sodium acetate and sodium citrate.