Control liquid containing an adsorbent

• US 6,613,570 B2
• Filed: 06/29/2001
• Issued: 09/02/2003
• Est. Priority Date: 07/03/2000
• Status: Expired due to Term

• Current Assignee: Roche Diabetes Care Inc. (Roche Holding AG)
• Original Assignee: Roche Diagnostics Corporation (Roche Holding AG)
• Inventors: Hoenes, Joachim, Zimmer, Volker, Knappe, Wolfgang-Reinhold, Hiller, Bernd, Gaa, Otto, Koschorreck, Beate, Wittmann, Franz
• Primary Examiner(s): WALLENHORST, MAUREEN
• Application Number:
  US09/897,794
• Publication Number:
  US 20020081740A1
• Time in Patent Office: 795 Days
• Field of Search: 436/8, 436/14, 436/16, 436/164, 436/169, 436/166, 436/180, 422/55, 422/56, 422/58, 422/100, 252/408.1, 435/14
• US Class Current: 436/14
• CPC Class Codes: G01N 33/66 involving blood sugars, e.g. galactose
• CPC Class Codes: G01N 33/96 involving blood or serum control standard
• CPC Class Codes: Y10T 436/10 Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
• CPC Class Codes: Y10T 436/104998 Glucose, ketone, nitrate standard or control

Abstract

An aqueous control liquid is provided that contains glucose at a known concentration and cyclodextrin. A method is also provided that binds a wetting agent from a region of a test element that comes into contact with a sample. The method includes contacting the region with a control liquid that has a substance selected from the group of cyclodextrin derivatives and dispersed materials having a specific surface of 100 m²/g to over 1000 m²/g. A method for controlling the function of a measuring system having test strips and a measuring instrument for the determination of glucose in liquid samples is provided that includes contacting the test strip with a control liquid containing glucose at a known concentration and at least one substance selected from the group consisting of cyclodextrins and cyclodextrin derivatives and detecting a signal caused by the glucose contained in the control liquid.

Claims

1. Aqueous control liquid containing glucose as a known concentration and a cyclodextrin selected from the group consisting of α

, β and

γ

cyclodextrin.

2. Control liquid as claimed in claim 1, wherein the cyclodextrin is present at a concentration of 5 mg/ml to 50 mg/ml.

3. Method of binding a wetting agent from a region of a test element that comes into contact with a sample comprising contacting the region of the test element that comes into contact with the sample with a control liquid that comprises glucose and a substance selected from the group consisting of cyclodextrin derivatives and dispersed materials having a specific surface of 100 m²/g to over 1000 m²/g, wherein the control liquid serves to at least partially bind a wetting agent located in said region of said test element.

4. Method as claimed in claim 3, wherein the cyclodextrin derivative is hydroxypropyl-β

-cyclodextrin.

5. Method as claimed in claim 3, wherein the substance selected from the group consisting of cyclodextrin derivatives and dispersed materials having a specific surface of 100 m²/g to over 1000 m²/g is present at a concentration of 5 mg/ml to 50 mg/ml.

6. Method of binding a wetting agent from a region of a test element that comes into contact with a sample comprising contacting the region of the test element that comes into contact with the sample with a control liquid that comprises glucose and a substance selected from the group consisting of cyclodextrin derivatives and dispersed materials having a specific surface of 100 m²/g to over 1000 m²/g, wherein the control liquid serves to at least partially bind a wetting agent located in said region of said test element and the dispersed material having a specific surface of 100 m²/g to over 1000 m²/g is active charcoal or silicon dioxide.

7. Method for controlling the function of a measuring system comprising a test strip and a measuring instrument for the determination of glucose in liquid samples comprising contacting the test strip of the measuring system with a control liquid containing glucose at a known concentration and at least one substance selected from the group consisting of cyclodextrins and cyclodextrin derivatives and detecting a signal caused by the glucose contained in the control liquid.

8. Method as claimed in claim 7, wherein the cyclodextrin derivative is hydroxypropyl-β

-cyclodextrin.

9. Method as claimed in claim 7, wherein the substance selected from the group consisting of cyclodextrins and cyclodextrin derivatives is present at a concentration of 5 mg/ml to 50 mg/ml.