BMP-6 proteins

• US 6,613,744 B2
• Filed: 03/23/2001
• Issued: 09/02/2003
• Est. Priority Date: 07/01/1986
• Status: Expired due to Fees

• Current Assignee: Genetics Institute LLC (Pfizer Inc.)
• Original Assignee: Genetics Institute LLC (Pfizer Inc.)
• Inventors: Wang, Elizabeth A., Wozney, John M., Rosen, Vicki A., Celeste, Anthony J.
• Primary Examiner(s): Romeo, David S.
• Application Number:
  US09/816,299
• Publication Number:
  US 20020061577A1
• Time in Patent Office: 893 Days
• Field of Search: 514/12, 530/350
• US Class Current: 514/8.8
• CPC Class Codes: A61K 38/00 Medicinal preparations containing peptides peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00
• CPC Class Codes: A61L 24/043 Mixtures of macromolecular materials
• CPC Class Codes: A61L 27/227 Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
• CPC Class Codes: C07K 14/51 Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
• CPC Class Codes: C08L 89/00 Compositions of proteins; Compositions of derivatives thereof foodstuff preparations A23J3/00
• CPC Class Codes: C12N 15/85 for animal cells
• CPC Class Codes: Y10S 530/84 Bones; tendons; teeth; cartilage

Abstract

Purified BMP-6 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and/or cartilage defects and in wound healing and related tissue repair.

Claims

1. A method for inducing bone and/or cartilage formation in a patient comprising administering to said patient an effective amount of a BMP-6 protein wherein said BMP-6 protein comprises amino acids #412 through #513 of Table III.

2. The method of claim 1 wherein said BMP-6 protein comprises amino acids #388 through #513 of Table III.

3. The method of claim 1 wherein said BMP-6 protein comprises amino acids #382 through #513 of Table III.

4. The method of claim 1 wherein said BMP-6 protein comprises the amino acid sequence of Table III.