Peptide nucleic acids having 2,6-diaminopurine nucleobases
First Claim
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1. A peptide nucleic acid having formula:
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wherein;
each L is independently selected from a group consisting of naturally-occurring nucleobases and non-naturally-occurring nucleobases, at least one of said L being a 2,6-diaminopurine nucleobase;
each R7′
is independently hydrogen or C1-C8 alkylamine;
Rh is OH, NH2 or NHLysNH2;
Ri is H, COCH3 or t-butoxycarbonyl; and
n is an integer from 1 to 30.
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Abstract
A novel class of compounds, known as peptide nucleic acids, bind complementary DNA and RNA strands more strongly than a corresponding DNA strand, and exhibit increased sequence specificity and binding affinity. The peptide nucleic acids of the invention comprise ligands selected from a group consisting of naturally-occurring nucleobases and non-naturally-occurring nucleobases attached to a polyamide backbone. Some PNAs of the invention also contain C1-C8 alkylamine side chains.
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Citations
23 Claims
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1. A peptide nucleic acid having formula:
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wherein; each L is independently selected from a group consisting of naturally-occurring nucleobases and non-naturally-occurring nucleobases, at least one of said L being a 2,6-diaminopurine nucleobase;
each R7′
is independently hydrogen or C1-C8 alkylamine;
Rh is OH, NH2 or NHLysNH2;
Ri is H, COCH3 or t-butoxycarbonyl; and
n is an integer from 1 to 30. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 23)
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14. A compound having formula:
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wherein; L is a 2,6-diaminopurine nucleobase;
R7′
is hydrogen or C1-C8 alkylamine;
E is COOH or an activated or protected derivative thereof; and
Z is NH2 or NHPg, where Pg is an amino-protecting group. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22)
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Specification