Polynucleotides that encode bovine inhibin
First Claim
1. A polynucleotide sequence which codes for 58 kD bovine inhibin comprising amino acids His 1 to Ile 300 of FIG. 5 and amino acids Gly 1 to Ser 116 of FIG. 6, or 31 kD bovine inhibin comprising amino acids Ser 167 to Ile 300 of FIG. 5 and amino acids Gly 1 and Ser 116 of FIG. 6, or a precursor or subunit of bovine inhibin selected from the group consisting of a 43 kD subunit which comprises amino acids His 1 to Ile 300 of FIG. 5, a 20 kD subunit comprising amino acids Ser 167 to Ile 300 of FIG. 5, a 15 kD subunit comprising amino acids Gly 1 to Ser 116 to FIG. 6, and an AN subunit comprising amino acids His 1 to Arg 166 of FIG. 5.
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Accused Products
Abstract
Recombinant nucleic acid molecules encoding 58 kD, 43 kD, 31 kD, 20 kD and 15 kD bovine inhibin and bovine inhibin subunits are disclosed. Vectors, host cells comprising recombinant nucleic acid molecules encoding bovine inhibin and bovine inhibin subunits are disclosed. In addition, methods for producing bovine inhibin and bovine inhibin subunits are disclosed.
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Citations
38 Claims
- 1. A polynucleotide sequence which codes for 58 kD bovine inhibin comprising amino acids His 1 to Ile 300 of FIG. 5 and amino acids Gly 1 to Ser 116 of FIG. 6, or 31 kD bovine inhibin comprising amino acids Ser 167 to Ile 300 of FIG. 5 and amino acids Gly 1 and Ser 116 of FIG. 6, or a precursor or subunit of bovine inhibin selected from the group consisting of a 43 kD subunit which comprises amino acids His 1 to Ile 300 of FIG. 5, a 20 kD subunit comprising amino acids Ser 167 to Ile 300 of FIG. 5, a 15 kD subunit comprising amino acids Gly 1 to Ser 116 to FIG. 6, and an AN subunit comprising amino acids His 1 to Arg 166 of FIG. 5.
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19. A process for manufacture of a recombinant DNA molecule, which comprises:
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(a) providing a DNA insert comprising a DNA sequence which on expression codes for a polypeptide selected from the group consisting of;
(i) 58 kD bovine inhibin having the sequence of amino acids His 1 to Ile 300 of FIG. 5 and amino acids Gly 1 to Ser 116 of FIG. 6, (ii) 31 kD bovine inhibin having the sequence of amino acids Ser 167 to Ile 300 of FIG. 5 and amino acids Gly 1 to Ser 116 of FIG. 6, (iii) 43 kD subunit of bovine inhibin having the sequence of amino acids His 1 to Ile 300 of FIG. 5, (iv) 20 kD subunit of bovine inhibin having the sequence of amino acids Ser 167 to Ile 300 of FIG. 5, (v) 15 kD subunit of bovine inhibin having the sequence of amino acids Gly 1 to Ser 116 of FIG. 6, (vi) AN subunit of bovine inhibin having the sequence of amino acids His 1 to Arg 166 of FIG. 5, (vii) bovine inhibin A subunit having the sequence of amino acids in FIG. 5, and (viii) bovine inhibin B subunit having the sequence of amino acids in FIG. 6; and
(b) cloning said DNA insert into a cloning vehicle to produce a recombinant DNA molecule. - View Dependent Claims (20, 21, 22, 23)
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Specification
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- Resources
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Current AssigneeBiotechnology Australia Pty., Limited (Danaher Corporation), Prince Henry's Institute of Medical Research (Hudson Institute of Medical Research), Monash University, St. Vincent'S Institute Of Medical Research
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Original AssigneeInhibin Pty Ltd. (Danaher Corporation)
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InventorsFindlay, John Kerr, Forage, Robert Gregory, de Kretser, David Moritz, Stewart, Andrew George, Milne-Robertson, David Mark
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Primary Examiner(s)Gambel, Phillip
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Application NumberUS08/478,696Time in Patent Office3,009 DaysField of Search530/387.1, 530/388.24, 530/350, 435/70.21, 435/240.27, 435/69.1, 435/252.3, 536/23.1, 536/23.5US Class Current536/23.5CPC Class CodesA61K 38/00 Medicinal preparations cont...A61K 39/00 Medicinal preparations cont...A61P 13/02 of urine or of the urinary ...A61P 15/00 Drugs for genital or sexual...C07K 14/575 Hormones derived from pro-o...C07K 16/26 against hormones ; against ...
