Differential conductivity hemodynamic monitor

• US 6,614,212 B2
• Filed: 09/10/2002
• Issued: 09/02/2003
• Est. Priority Date: 09/30/1992
• Status: Expired due to Fees

• Current Assignee: Gambro Renal Products, Inc. (Baxter International Inc.)
• Original Assignee: Gambro, Inc. (DaVita Incorporated)
• Inventors: Buffaloe, George W. IV, Ogawa, Francis T., Brugger, James M.
• Primary Examiner(s): Hirshfeld, Andrew H.
• Assistant Examiner(s): Hamdan, Wasseem H.
• Application Number:
  US10/238,164
• Publication Number:
  US 20030016002A1
• Time in Patent Office: 357 Days
• Field of Search: 324/445, 324/71.1, 324/425, 324/439, 324/692, 324/705, 324/444, 324/450, 210/96.1, 210/646, 738/610.7, 738/610.8, 738/610.4, 436/150, 604/30, 604/25, 604/246, 604/4
• US Class Current: 324/71.1
• CPC Class Codes: A61M 1/16 with membranes
• CPC Class Codes: A61M 1/361 before treatment
• CPC Class Codes: A61M 1/3612 after treatment
• CPC Class Codes: A61M 1/3653 Interfaces between patient blood circulation and extra-corporal blood circuit
• CPC Class Codes: A61M 1/3655 Arterio-venous shunts or fistulae
• CPC Class Codes: A61M 1/3658 Indicating the amount of purified blood recirculating in the fistula or shunt
• CPC Class Codes: A61M 1/3659 Cannulae pertaining to extracorporeal circulation
• CPC Class Codes: A61M 1/3661 for haemodialysis
• CPC Class Codes: A61M 1/3669 Electrical impedance measurement of body fluids; transducers specially adapted therefor
• CPC Class Codes: G01F 1/7046 using electrical loaded particles as tracer, e.g. ions or electrons
• CPC Class Codes: G01F 1/708 Measuring the time taken to traverse a fixed distance
• CPC Class Codes: G01F 1/7088 using electrically charged particles as tracers

Abstract

Method and apparatus for quantitatively determining a degree of recirculalion flow in a vessel of a fluid by altering the electrical conductivity of the fluid, sensing the difference in electromagnetic field after the fluid is altered, and integrating the sensed difference over a period of time including any time of potential recirculation of any altered conductivity fluid.

Claims

1. A method for quantitatively determining a degree of recirculation flow in a vessel of a first fluid having a first electrical conductivity relative to a second fluid having a corresponding second electrical conductivity, comprising:

altering the electrical conductivity of the first fluid;

inducing a first electrical current in the first fluid and a second electrical current in the second fluid, said first current generating a first electromagnetic field and said second current generating a second electromagnetic field;

sensing the difference between the first and second electromagnetic fields at a sensing location alter the conductivity of the first fluid is altered;

integrating the sensed difference between the first and second electromagnetic fields over a period of time after the altering step and including any time of potential recirculation of any altered conductivity first fluid; and

interpreting the time integrated value of the difference between the first and second electromagnetic fields to quantitatively determine a degree of recirculation flow.

2. A method as defined in claim 1 wherein:

the step of altering the electrical conductivity of the first fluid further comprises;

injecting a marker fluid having a conductivity different from the conductivity of the first fluid into the first fluid.

3. A method as defined in claim 1 wherein the step of sensing the difference of the first and second electromagnetic fields further comprises:

flowing the first fluid through a first conduit, said first conduit comprising a first conductivity cell with a continuous path configuration; and

wherein

said inducing step further comprises inducing the first electrical current in the first fluid in the first conductivity cell following the continuous path configuration.

4. A method as defined in claim 3 wherein:

the inducing step further comprises;

positioning an exciting electromagnetic coil in proximity with the first conductivity cell at an inducing location; and

inducing the first electrical current in an electrical direction along the continuous path of the first conductivity cell; and

the sensing step further comprises;

positioning a sensing electromagnetic coil in proximity with the first conductivity cell at a sensing location.

5. A method as defined in claim 1 wherein the interpreting step further comprises compensating for the effect of the first conductivity of the first fluid.

6. A method as defined in claim 1 wherein the step of sensing the difference of the first and second electromagnetic fields further comprises:

flowing the second fluid in a second conduit, the second conduit having a second conductivity cell with a continuous path configuration and wherein the inducing step further comprises;

inducing the second electrical current in the second fluid in the second conductivity cell following the continuous path configuration.

7. A method as defined in claim 6 wherein the interpreting step further comprises compensating for the effects of the first conductivity of the first fluid and the second conductivity of the second fluid.

8. A method as defined in claim 1 wherein the step of sensing the difference of the first and the second electromagnetic fields further comprises:

flowing the first fluid through a first conduit, said first conduit comprising a first conductivity cell with a first continuous path configuration;

flowing the second fluid through a second conduit, said second conduit comprising a second conductivity cell with a second continuous path configuration;

wherein said inducing step includes inducing a first electrical current in the first fluid in the first conductivity cell and inducing a second electrical current in the second fluid in the second conductivity cell;

wherein said sensing step includes sensing the difference between the first electromagnetic field of the first fluid in the first conductivity cell and the second electromagnetic field of the second fluid in the second conductivity cell; and

producing a signal representative of the difference of the first and second electromagnetic fields of the first and the second fluids.

9. A method as defined in claim 8 wherein:

the inducing step further comprises;

positioning an exciting electromagnetic coil in proximity with the first and second conductivity cells at an inducing location;

inducing the first electrical current in an electrical direction along the first continuous path of the first conductivity cell; and

simultaneously inducing the second electrical current to flow in the same electrical direction along the second continuous path of the second conductivity cell as the direction of the first electrical current; and

the sensing step further comprises;

positioning a sensing electromagnetic coil in proximity with the first and second conductivity cells at a sensing location with the first conductivity cell oriented at the sensing location with the first electrical current disposed in an opposite electrical direction from the electrical direction of the second electrical current.

10. An apparatus for quantitatively determining a degree of recirculation flow of a first fluid in a vessel, said first fluid having a first electrical conductivity relative to a second fluid having a corresponding second electrical conductivity, comprising:

means for altering the electrical conductivity of the first fluid; and

means for inducing a first electrical current in the first fluid and a second electrical current in the second fluid, said first current generating a first electromagnetic field and said second current generating a second electromagnetic field;

means for sensing the difference between the first and second electromagnetic fields after the conductivity of the first fluid is altered;

means for integrating the sensed difference between the first and second electromagnetic fields over a period of time after the electrical conductivity of the first fluid has been altered and after any time of potential recirculation of any altered conductivity first fluid; and

means for interpreting the time integrated value of the difference between the first and second electromagnetic fields to quantitatively determine the degree of recirculation flow.

11. An apparatus as defined in claim 10 wherein:

the means for altering the electrical conductivity of the first fluid further comprises;

means for injecting a marker fluid having an electrical conductivity different from the first conductivity of the first fluid into the first fluid.

12. An apparatus as defined in claim 10 wherein the means for sensing the difference of the electromagnetic fields of the first fluid and the second fluid further comprises:

a first conduit through which the first fluid flows to the vessel, said first conduit comprising a first conductivity cell with a first conductivity cell upstream connection, a first conductivity cell downstream connection, and two branches connecting the upstream connection to the downstream connection with a continuous path configuration from the upstream connection to the downstream connection through one of the two branches and returning to the upstream connection through the other one of the two branches;

wherein the means for inducing the first electrical current is in the first fluid is in the first conductivity cell following the continuous path configuration.

13. An apparatus as defined in claim 12 wherein:

the inducing means comprises an exciting electromagnetic coil disposed in proximity with the first conductivity cell at an exciting location; and

the sensing means comprises;

a sensing electromagnetic coil disposed in proximity with the first conductivity cell at a sensing location.

14. An apparatus as defined in claim 10 wherein the means for interpreting further comprises means for compensating for the effect of the first conductivity of the first fluid.

15. An apparatus as defined in claim 12 wherein the means for sensing the difference of the first and second electromagnetic fields further comprises:

a second conduit through which the second fluid having the second conductivity flows, the second conduit having a second conductivity cell with a second continuous configuration wherein the means for inducing the second electrical current in the second fluid is in the second conductivity cell following the second continuous path configuration.

16. An apparatus as defined in claim 15 wherein the means for sensing the difference of the first and the second electromagnetic fields further comprises:

a first conduit through which the first fluid flows to the vessel, said first conduit comprising a first conductivity cell with a first conductivity cell upstream connection, a first conductivity cell downstream connection, and two branches connecting the upstream connection to the downstream connection with a first continuous path configuration from the upstream connection to the downstream connection through one of the two branches and returning to the upstream connection through the other one of the two branches;

a second conduit through which the second fluid flows from the vessel, said second conduit comprising a second conductivity cell with a second conductivity cell upstream connection, a second conductivity cell downstream connection, and two branches connecting the upstream connection to the downstream connection with a second continuous path configuration from the upstream connection to the downstream connection through one of the two branches and returning to the upstream connection through the other one of the two branches;

wherein said means for inducing includes inducing a first electrical current in the first fluid in the first conductivity cell and inducing a second electrical current in the second fluid in the second conductivity cell;

wherein said means for sensing includes sensing the difference between the first electromagnetic field of the first fluid in the first conductivity cell and the second electromagnetic field of the second fluid flowing in the second conductivity cell, and

means for producing a signal representative of the difference of the first and second electromagnetic fields of the first and the second fluids.

17. An apparatus as defined in claim 16 wherein:

the inducing means further comprises

an exciting electromagnetic coil disposed in proximity with the first and second conductivity cells at an exciting location, the first conductivity cell being oriented at the exciting location with respect to the second conductivity cell with the first electrical current in a first electrical direction with respect to the exciting electromagnetic coil along the first continuous path of the first conductivity cell and the second electrical current in a second electrical direction along the second continuous path of the second conductivity cell which is the same electrical direction with respect to the exciting electromagnetic coil as the direction of the first electrical current; and

the sensing means further comprises a sensing electromagnetic coil disposed in proximity with the first and second conductivity cells at a sensing location, the first conductivity cell being oriented at the sensing location with respect to the second conductivity cell with the first electrical direction of the first electrical current with respect to the sensing electromagnetic coil disposed opposite the second electrical direction of the second electrical current with respect to the sensing electromagnetic coil.